CATH Domain 5i50B00

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CATH Classification

Level	CATH Code	Description
	4	Few Secondary Structures
	4.10	Irregular
	4.10.280	MYOD Basic-Helix-Loop-Helix Domain, subunit B
	4.10.280.10	Helix-loop-helix DNA-binding domain

Domain Context

CATH Clusters

Superfamily	Helix-loop-helix DNA-binding domain
Functional Family	Myc proto-oncogene protein

Enzyme Information

UniProtKB Entries (1)

MYC_HUMAN

Homo sapiens

Myc proto-oncogene protein

PDB Structure

PDB	5I50
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. Jung, L.A., Gebhardt, A., Koelmel, W., Ade, C.P., Walz, S., Kuper, J., von Eyss, B., Letschert, S., Redel, C., d'Artista, L., Biankin, A., Zender, L., Sauer, M., Wolf, E., Evan, G., Kisker, C., Eilers, M. Oncogene