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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: 2-isopropylmalate synthase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
2-isopropylmalate synthase activity GO:0003852
Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).
 22 P09151 (/IMP) P09151 (/IMP) P09151 (/IMP) P09151 (/IMP) P09151 (/IMP) P09151 (/IMP) P09151 (/IMP) P09151 (/IMP) P09151 (/IMP) P09151 (/IMP)
(12 more)
Acetyl-CoA C-acetyltransferase activity GO:0003985
Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
 22 P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA)
(12 more)
2-isopropylmalate synthase activity GO:0003852
Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).
 8 Q9C550 (/ISS) Q9KP83 (/ISS) Q9KP83 (/ISS) Q9KP83 (/ISS) Q9KP83 (/ISS) Q9KP83 (/ISS) Q9KP83 (/ISS) Q9KP83 (/ISS)
2-isopropylmalate synthase activity GO:0003852
Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).
 3 Q9C550 (/IDA) Q9LPR4 (/IDA) Q9LPR4 (/IDA)
2-(2'-methylthio)ethylmalate synthase activity GO:0010177
Catalysis of the reaction: 2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O = 2-(2'-methylthio)ethylmalic-acid + coenzyme A + H+.
 2 Q9FG67 (/IDA) Q9FN52 (/IDA)
2-isopropylmalate synthase activity GO:0003852
Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).
 1 Q9C550 (/IGI)
2-isopropylmalate synthase activity GO:0003852
Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).
 1 Q9FN52 (/NAS)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
 25 P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA)
(15 more)
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
 24 P09151 (/IMP) P09151 (/IMP) P09151 (/IMP) P09151 (/IMP) P09151 (/IMP) P09151 (/IMP) P09151 (/IMP) P09151 (/IMP) P09151 (/IMP) P09151 (/IMP)
(14 more)
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
 7 Q9KP83 (/ISS) Q9KP83 (/ISS) Q9KP83 (/ISS) Q9KP83 (/ISS) Q9KP83 (/ISS) Q9KP83 (/ISS) Q9KP83 (/ISS)
Glucosinolate biosynthetic process GO:0019761
The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae.
 2 Q9FG67 (/IDA) Q9FN52 (/IDA)
Glucosinolate biosynthetic process GO:0019761
The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae.
 2 Q9FG67 (/IMP) Q9FN52 (/IMP)
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
 1 Q9C550 (/IGI)
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
 1 Q9FN52 (/TAS)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
 1 Q9FG67 (/IEP)
Response to insect GO:0009625
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect.
 1 Q9FG67 (/IEP)
Coenzyme B biosynthetic process GO:0019298
The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes.
 1 Q57926 (/IDA)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 22 P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA) P09151 (/IDA)
(12 more)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
 5 Q9C550 (/IDA) Q9FG67 (/IDA) Q9FN52 (/IDA) Q9LPR4 (/IDA) Q9LPR4 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
 2 Q9LPR4 (/IDA) Q9LPR4 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
 1 Q9FG67 (/ISS)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
 1 Q9C550 (/IDA)