The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
VKOR domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Vitamin K epoxide reductase complex subunit 1-like...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Vitamin-K-epoxide reductase (warfarin-sensitive) activity GO:0047057
Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
13 Q6TEK3 (/IDA) Q6TEK3 (/IDA) Q6TEK5 (/IDA) Q6TEK5 (/IDA) Q8N0U8 (/IDA) Q8N0U8 (/IDA) Q9BQB6 (/IDA) Q9BQB6 (/IDA) Q9BQB6 (/IDA) Q9BQB6 (/IDA)
(3 more)
Vitamin-K-epoxide reductase (warfarin-sensitive) activity GO:0047057
Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
4 Q6TEK5 (/ISO) Q6TEK5 (/ISO) Q9CRC0 (/ISO) Q9CRC0 (/ISO)
Vitamin-K-epoxide reductase (warfarin-sensitive) activity GO:0047057
Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
2 Q8N0U8 (/EXP) Q8N0U8 (/EXP)
Vitamin-K-epoxide reductase (warfarin-sensitive) activity GO:0047057
Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
2 Q6B4J2 (/ISS) Q6B4J2 (/ISS)
Vitamin-K-epoxide reductase (warfarin-insensitive) activity GO:0047058
Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
2 Q6TEK4 (/IDA) Q6TEK4 (/IDA)
Vitamin-K-epoxide reductase (warfarin-insensitive) activity GO:0047058
Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
2 Q9CRC0 (/ISO) Q9CRC0 (/ISO)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Vitamin K metabolic process GO:0042373
The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.
13 Q6TEK3 (/IDA) Q6TEK3 (/IDA) Q6TEK5 (/IDA) Q6TEK5 (/IDA) Q8N0U8 (/IDA) Q8N0U8 (/IDA) Q9BQB6 (/IDA) Q9BQB6 (/IDA) Q9BQB6 (/IDA) Q9BQB6 (/IDA)
(3 more)
Peptidyl-glutamic acid carboxylation GO:0017187
The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase.
10 Q6B4J2 (/ISS) Q6B4J2 (/ISS) Q6TEK3 (/ISS) Q6TEK3 (/ISS) Q6TEK4 (/ISS) Q6TEK4 (/ISS) Q6TEK5 (/ISS) Q6TEK5 (/ISS) Q9CRC0 (/ISS) Q9CRC0 (/ISS)
Bone development GO:0060348
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
9 Q6B4J2 (/ISS) Q6B4J2 (/ISS) Q6TEK4 (/ISS) Q6TEK4 (/ISS) Q9BQB6 (/ISS) Q9BQB6 (/ISS) Q9BQB6 (/ISS) Q9BQB6 (/ISS) Q9BQB6 (/ISS)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
7 Q9BQB6 (/IMP) Q9BQB6 (/IMP) Q9BQB6 (/IMP) Q9BQB6 (/IMP) Q9BQB6 (/IMP) Q9CRC0 (/IMP) Q9CRC0 (/IMP)
Peptidyl-glutamic acid carboxylation GO:0017187
The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase.
7 Q8N0U8 (/IMP) Q8N0U8 (/IMP) Q9BQB6 (/IMP) Q9BQB6 (/IMP) Q9BQB6 (/IMP) Q9BQB6 (/IMP) Q9BQB6 (/IMP)
Vitamin K metabolic process GO:0042373
The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.
7 Q8N0U8 (/TAS) Q8N0U8 (/TAS) Q9BQB6 (/TAS) Q9BQB6 (/TAS) Q9BQB6 (/TAS) Q9BQB6 (/TAS) Q9BQB6 (/TAS)
Drug metabolic process GO:0017144
The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.
5 Q9BQB6 (/IMP) Q9BQB6 (/IMP) Q9BQB6 (/IMP) Q9BQB6 (/IMP) Q9BQB6 (/IMP)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
4 Q6B4J2 (/ISS) Q6B4J2 (/ISS) Q6TEK4 (/ISS) Q6TEK4 (/ISS)
Peptidyl-glutamic acid carboxylation GO:0017187
The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase.
4 Q6TEK5 (/ISO) Q6TEK5 (/ISO) Q9CRC0 (/ISO) Q9CRC0 (/ISO)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
4 Q6TEK3 (/ISS) Q6TEK3 (/ISS) Q6TEK5 (/ISS) Q6TEK5 (/ISS)
Vitamin K metabolic process GO:0042373
The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.
4 Q6TEK5 (/ISO) Q6TEK5 (/ISO) Q9CRC0 (/ISO) Q9CRC0 (/ISO)
Vitamin K metabolic process GO:0042373
The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.
4 Q6B4J2 (/ISS) Q6B4J2 (/ISS) Q6TEK4 (/ISS) Q6TEK4 (/ISS)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
2 Q9CRC0 (/ISO) Q9CRC0 (/ISO)
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
2 Q6TEK4 (/IDA) Q6TEK4 (/IDA)
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
2 Q9CRC0 (/ISO) Q9CRC0 (/ISO)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
2 Q6TEK4 (/IDA) Q6TEK4 (/IDA)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
2 Q9CRC0 (/ISO) Q9CRC0 (/ISO)
Drug metabolic process GO:0017144
The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.
2 Q9CRC0 (/ISO) Q9CRC0 (/ISO)
Regulation of blood coagulation GO:0030193
Any process that modulates the frequency, rate or extent of blood coagulation.
2 Q6TEK4 (/IMP) Q6TEK4 (/IMP)
Regulation of blood coagulation GO:0030193
Any process that modulates the frequency, rate or extent of blood coagulation.
2 Q9CRC0 (/ISO) Q9CRC0 (/ISO)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 Q8N0U8 (/IMP) Q8N0U8 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 Q6TEK5 (/ISO) Q6TEK5 (/ISO)
Vitamin K biosynthetic process GO:0042371
The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals.
2 Q9CRC0 (/ISO) Q9CRC0 (/ISO)
Vitamin K metabolic process GO:0042373
The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.
2 Q9CRC0 (/IMP) Q9CRC0 (/IMP)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
2 Q6TEK4 (/IDA) Q6TEK4 (/IDA)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
2 Q9CRC0 (/ISO) Q9CRC0 (/ISO)
Positive regulation of coagulation GO:0050820
Any process that activates or increases the frequency, rate or extent of coagulation.
2 Q9CRC0 (/IMP) Q9CRC0 (/IMP)
Bone development GO:0060348
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
2 Q9CRC0 (/IMP) Q9CRC0 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
12 A0A0S2Z6I4 (/IDA) A0A0S2Z6I4 (/IDA) A0A0S2Z6I4 (/IDA) A0A0S2Z6I4 (/IDA) A0A0S2Z6I4 (/IDA) Q8N0U8 (/IDA) Q8N0U8 (/IDA) Q9BQB6 (/IDA) Q9BQB6 (/IDA) Q9BQB6 (/IDA)
(2 more)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
7 Q8N0U8 (/TAS) Q8N0U8 (/TAS) Q9BQB6 (/TAS) Q9BQB6 (/TAS) Q9BQB6 (/TAS) Q9BQB6 (/TAS) Q9BQB6 (/TAS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
4 Q6TEK5 (/ISO) Q6TEK5 (/ISO) Q9CRC0 (/ISO) Q9CRC0 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
4 Q6TEK3 (/ISS) Q6TEK3 (/ISS) Q6TEK5 (/ISS) Q6TEK5 (/ISS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 Q8N0U8 (/IDA) Q8N0U8 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 Q6TEK5 (/ISO) Q6TEK5 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 Q6TEK4 (/IDA) Q6TEK4 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 Q9CRC0 (/ISO) Q9CRC0 (/ISO)
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