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CATH Superfamily 1.20.1440.130

VKOR domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
VKOR domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Vitamin K epoxide reductase complex subunit 1-like...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Vitamin-K-epoxide reductase (warfarin-sensitive). [EC: 1.17.4.4]
(1) Phylloquinone + a protein with a disulfide bond + H(2)O = 2,3- epoxyphylloquinone + a protein with reduced L-cysteine residues. (2) Phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues.
  • The enzyme catalyzes the reduction of vitamin K 2,3-epoxide, which is formed by the activity of EC 4.1.1.90, back to its phylloquinol active form.
  • The enzyme forms a tight complex with EC 5.3.4.1, which transfers the required electrons from newly-synthesized proteins by catalyzing the formation of disulfide bridges.
  • The enzyme acts on the epoxide forms of both phylloquinone (vitamin K1) and menaquinone (vitamin K2).
  • Inhibited strongly by (S)-warfarin and ferulenol.
  • Formerly EC 1.1.4.1.
 45 A0A0S2Z6I4 A0A0S2Z6I4 A0A0S2Z6I4 A0A0S2Z6I4 A0A0S2Z6I4 A0A2R9BGD1 A0A2R9BGD1 A0A2R9BGD1 A0A2R9BGD1 A0A2R9BGD1
(35 more...)
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