CATH Domain 5ns5A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.140	Metal-dependent hydrolases

Domain Context

CATH Clusters

Superfamily	Metal-dependent hydrolases
Functional Family	Dipeptidase gliJ

Enzyme Information

3.4.13.19

Membrane dipeptidase.

based on mapping to UniProt Q4WMJ8

Hydrolysis of dipeptides.

-!- Membrane bound, with broad specificity. -!- Abundant in the kidney cortex. -!- Inhibited by bestatin and cilastatin. -!- Belongs to peptidase family M19. -!- Formerly EC 3.4.3.1, EC 3.4.3.2, EC 3.4.3.6, EC 3.4.13.1, EC 3.4.13.2, EC 3.4.13.8, EC 3.4.13.11 and EC 3.4.13.15.

UniProtKB Entries (1)

Q4WMJ8

GLIJ_ASPFU

Aspergillus fumigatus Af293

Dipeptidase gliJ

PDB Structure

PDB	5NS5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ. Marion, A., Groll, M., Scharf, D.H., Scherlach, K., Glaser, M., Sievers, H., Schuster, M., Hertweck, C., Brakhage, A.A., Antes, I., Huber, E.M. ACS Chem. Biol.