CATH Domain 4axkA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Enzyme Information

5.3.1.16

1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase.

based on mapping to UniProt Q8FNZ7

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D- ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1- deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide.

-!- Involved in histidine biosynthesis.

UniProtKB Entries (1)

Q8FNZ7

HIS4_COREF

Corynebacterium efficiens YS-314

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

PDB Structure

PDB	4AXK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Evolution of Substrate Specificity in a Recipient'S Enzyme Following Horizontal Gene Transfer. Noda-Garcia, L., Camacho-Zarco, A.R., Medina-Ruiz, S., Gaytan, P., Carrillo-Tripp, M., Fulop, V., Barona-Gomez, F. Mol.Biol.Evol.