The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Helix-loop-helix DNA-binding domain
".
FunFam 12: hairy/enhancer-of-split related with YRPW motif pr...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 38 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
13 |
Q9DBX7 (/IPI)
Q9I9L0 (/IPI)
Q9NQ87 (/IPI)
Q9QUS4 (/IPI)
Q9QUS4 (/IPI)
Q9UBP5 (/IPI)
Q9UBP5 (/IPI)
Q9UBP5 (/IPI)
Q9WV93 (/IPI)
Q9Y5J3 (/IPI)
(3 more) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
10 | Q9NQ87 (/IDA) Q9QUS4 (/IDA) Q9QUS4 (/IDA) Q9UBP5 (/IDA) Q9UBP5 (/IDA) Q9UBP5 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
9 | Q9NQ87 (/IDA) Q9UBP5 (/IDA) Q9UBP5 (/IDA) Q9UBP5 (/IDA) Q9WV93 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
9 | Q9DBX7 (/IDA) Q9I8A3 (/IDA) Q9I8A3 (/IDA) Q9QUS4 (/IDA) Q9QUS4 (/IDA) Q9UBP5 (/IDA) Q9UBP5 (/IDA) Q9UBP5 (/IDA) Q9WV93 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
8 | Q9NQ87 (/ISA) Q9UBP5 (/ISA) Q9UBP5 (/ISA) Q9UBP5 (/ISA) Q9Y5J3 (/ISA) Q9Y5J3 (/ISA) Q9Y5J3 (/ISA) Q9Y5J3 (/ISA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
8 | Q9NQ87 (/ISM) Q9UBP5 (/ISM) Q9UBP5 (/ISM) Q9UBP5 (/ISM) Q9Y5J3 (/ISM) Q9Y5J3 (/ISM) Q9Y5J3 (/ISM) Q9Y5J3 (/ISM) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
8 | Q9NQ87 (/NAS) Q9UBP5 (/NAS) Q9UBP5 (/NAS) Q9UBP5 (/NAS) Q9Y5J3 (/NAS) Q9Y5J3 (/NAS) Q9Y5J3 (/NAS) Q9Y5J3 (/NAS) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
8 | Q9NQ87 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
8 | Q9NQ87 (/NAS) Q9UBP5 (/NAS) Q9UBP5 (/NAS) Q9UBP5 (/NAS) Q9Y5J3 (/NAS) Q9Y5J3 (/NAS) Q9Y5J3 (/NAS) Q9Y5J3 (/NAS) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
4 | Q9DBX7 (/ISO) Q9QUS4 (/ISO) Q9QUS4 (/ISO) Q9WV93 (/ISO) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
4 | Q9DBX7 (/IDA) Q9QUS4 (/IDA) Q9QUS4 (/IDA) Q9WV93 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
4 | Q9DBX7 (/ISO) Q9QUS4 (/ISO) Q9QUS4 (/ISO) Q9WV93 (/ISO) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
4 | Q9DBX7 (/ISS) Q9QUS4 (/ISS) Q9QUS4 (/ISS) Q9WV93 (/ISS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
4 | Q9DBX7 (/IDA) Q9QUS4 (/IDA) Q9QUS4 (/IDA) Q9WV93 (/IDA) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
4 | Q9NQ87 (/IDA) Q9QUS4 (/IDA) Q9QUS4 (/IDA) Q9WV93 (/IDA) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
3 | Q9UBP5 (/IPI) Q9UBP5 (/IPI) Q9UBP5 (/IPI) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
3 | Q9UBP5 (/IPI) Q9UBP5 (/IPI) Q9UBP5 (/IPI) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
2 | Q9QUS4 (/ISO) Q9QUS4 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | Q9I8A3 (/IDA) Q9I8A3 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | Q9DBX7 (/IDA) Q9NQ87 (/IDA) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
2 | Q9QUS4 (/IPI) Q9QUS4 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q9I8A3 (/IPI) Q9I8A3 (/IPI) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
2 | Q9QUS4 (/ISO) Q9QUS4 (/ISO) |
|
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
|
2 | Q9I8A3 (/IPI) Q9I8A3 (/IPI) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
2 | Q9QUS4 (/ISO) Q9QUS4 (/ISO) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | Q9I8A3 (/IPI) Q9I8A3 (/IPI) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | Q9DBX7 (/IDA) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | Q9DBX7 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q7KM13 (/ISS) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | Q9DBX7 (/ISO) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | Q9DBX7 (/ISS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q66KK8 (/ISS) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | Q66KK8 (/ISS) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | Q9DBX7 (/ISO) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | Q66KK8 (/ISS) |
|
AF-1 domain binding GO:0050683
Interacting selectively and non-covalently with the AF-1 domain of a protein, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor.
|
1 | Q9NQ87 (/IPI) |
|
AF-1 domain binding GO:0050683
Interacting selectively and non-covalently with the AF-1 domain of a protein, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor.
|
1 | Q9DBX7 (/ISO) |
There are 172 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
12 |
Q9I8A3 (/IDA)
Q9I8A3 (/IDA)
Q9QUS4 (/IDA)
Q9QUS4 (/IDA)
Q9UBP5 (/IDA)
Q9UBP5 (/IDA)
Q9UBP5 (/IDA)
Q9WV93 (/IDA)
Q9Y5J3 (/IDA)
Q9Y5J3 (/IDA)
(2 more) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
12 |
Q9I8A3 (/IMP)
Q9I8A3 (/IMP)
Q9QUS4 (/IMP)
Q9QUS4 (/IMP)
Q9UBP5 (/IMP)
Q9UBP5 (/IMP)
Q9UBP5 (/IMP)
Q9WV93 (/IMP)
Q9Y5J3 (/IMP)
Q9Y5J3 (/IMP)
(2 more) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
12 |
Q9I8A3 (/IDA)
Q9I8A3 (/IDA)
Q9NQ87 (/IDA)
Q9QUS4 (/IDA)
Q9QUS4 (/IDA)
Q9UBP5 (/IDA)
Q9UBP5 (/IDA)
Q9UBP5 (/IDA)
Q9Y5J3 (/IDA)
Q9Y5J3 (/IDA)
(2 more) |
|
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
11 |
Q2KIN4 (/ISS)
Q66KK8 (/ISS)
Q8AXV6 (/ISS)
Q8AXV6 (/ISS)
Q9DBX7 (/ISS)
Q9I8A3 (/ISS)
Q9I8A3 (/ISS)
Q9TSZ2 (/ISS)
Q9UBP5 (/ISS)
Q9UBP5 (/ISS)
(1 more) |
|
Notch signaling involved in heart development GO:0061314
The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time.
|
10 | Q9QUS4 (/IC) Q9QUS4 (/IC) Q9UBP5 (/IC) Q9UBP5 (/IC) Q9UBP5 (/IC) Q9WV93 (/IC) Q9Y5J3 (/IC) Q9Y5J3 (/IC) Q9Y5J3 (/IC) Q9Y5J3 (/IC) |
|
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
9 | G3V7S6 (/IDA) Q9NQ87 (/IDA) Q9QUS4 (/IDA) Q9QUS4 (/IDA) Q9WV93 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) |
|
Negative regulation of transcription regulatory region DNA binding GO:2000678
Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding.
|
9 | Q9QUS4 (/IDA) Q9QUS4 (/IDA) Q9UBP5 (/IDA) Q9UBP5 (/IDA) Q9UBP5 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) |
|
Pulmonary valve morphogenesis GO:0003184
The process in which the structure of the pulmonary valve is generated and organized.
|
8 | Q9NQ87 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Cardiac ventricle morphogenesis GO:0003208
The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
|
8 | Q9NQ87 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Cardiac epithelial to mesenchymal transition GO:0060317
A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
8 | Q9NQ87 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Ventricular septum morphogenesis GO:0060412
The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.
|
8 | Q9NQ87 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
7 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Dorsal aorta morphogenesis GO:0035912
The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.
|
7 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Umbilical cord morphogenesis GO:0036304
The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta.
|
7 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
7 | Q9UBP5 (/TAS) Q9UBP5 (/TAS) Q9UBP5 (/TAS) Q9Y5J3 (/TAS) Q9Y5J3 (/TAS) Q9Y5J3 (/TAS) Q9Y5J3 (/TAS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
7 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Cardiac septum morphogenesis GO:0060411
The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.
|
7 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Labyrinthine layer blood vessel development GO:0060716
The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.
|
7 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Arterial endothelial cell differentiation GO:0060842
The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries.
|
7 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Negative regulation of biomineral tissue development GO:0070168
Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.
|
7 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Regulation of vasculogenesis GO:2001212
Any process that modulates the frequency, rate or extent of vasculogenesis.
|
7 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
|
6 | Q9QUS4 (/IDA) Q9QUS4 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
6 | Q9DBX7 (/IMP) Q9I8A3 (/IMP) Q9I8A3 (/IMP) Q9QUS4 (/IMP) Q9QUS4 (/IMP) Q9WV93 (/IMP) |
|
Negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation GO:2000820
Any negative regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation.
|
6 | Q9QUS4 (/IDA) Q9QUS4 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) Q9Y5J3 (/IDA) |
|
Endocardial cushion morphogenesis GO:0003203
The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
|
5 | Q9NQ87 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
4 | Q9Y5J3 (/IEP) Q9Y5J3 (/IEP) Q9Y5J3 (/IEP) Q9Y5J3 (/IEP) |
|
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
|
4 | Q9I9L0 (/IGI) Q9QUS4 (/IGI) Q9QUS4 (/IGI) Q9WV93 (/IGI) |
|
Outflow tract morphogenesis GO:0003151
The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
|
4 | Q9NQ87 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Aortic valve morphogenesis GO:0003180
The process in which the structure of the aortic valve is generated and organized.
|
4 | Q9NQ87 (/TAS) Q9UBP5 (/TAS) Q9UBP5 (/TAS) Q9UBP5 (/TAS) |
|
Atrioventricular valve formation GO:0003190
The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
|
4 | Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198
A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion.
|
4 | Q9NQ87 (/TAS) Q9UBP5 (/TAS) Q9UBP5 (/TAS) Q9UBP5 (/TAS) |
|
Cardiac ventricle morphogenesis GO:0003208
The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
|
4 | Q9DBX7 (/IMP) Q9QUS4 (/IMP) Q9QUS4 (/IMP) Q9WV93 (/IMP) |
|
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
4 | Q9DBX7 (/ISO) Q9QUS4 (/ISO) Q9QUS4 (/ISO) Q9WV93 (/ISO) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
4 | Q9DBX7 (/IMP) Q9QUS4 (/IMP) Q9QUS4 (/IMP) Q9WV93 (/IMP) |
|
Mesenchymal cell development GO:0014031
The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
|
4 | Q9NQ87 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | Q9DBX7 (/ISO) Q9QUS4 (/ISO) Q9QUS4 (/ISO) Q9WV93 (/ISO) |
|
Heart trabecula formation GO:0060347
The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.
|
4 | Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Notch signaling involved in heart development GO:0061314
The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time.
|
4 | Q9NQ87 (/TAS) Q9UBP5 (/TAS) Q9UBP5 (/TAS) Q9UBP5 (/TAS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | Q9QUS4 (/ISO) Q9QUS4 (/ISO) Q9WV93 (/ISO) |
|
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
|
3 | Q9QUS4 (/IGI) Q9QUS4 (/IGI) Q9WV93 (/IGI) |
|
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
|
3 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Muscular septum morphogenesis GO:0003150
The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.
|
3 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Tricuspid valve morphogenesis GO:0003186
The process in which the structure of the tricuspid valve is generated and organized.
|
3 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199
A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.
|
3 | Q9QUS4 (/IGI) Q9QUS4 (/IGI) Q9WV93 (/IGI) |
|
Cardiac left ventricle morphogenesis GO:0003214
The process in which the left cardiac ventricle is generated and organized.
|
3 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Cardiac right ventricle morphogenesis GO:0003215
The process in which the right cardiac ventricle is generated and organized.
|
3 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Ventricular trabecula myocardium morphogenesis GO:0003222
The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized.
|
3 | Q9QUS4 (/IGI) Q9QUS4 (/IGI) Q9WV93 (/IGI) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | Q9DBX7 (/ISS) Q9QUS4 (/ISS) Q9QUS4 (/ISS) |
|
Anterior/posterior axis specification GO:0009948
The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
3 | Q9QUS4 (/IGI) Q9QUS4 (/IGI) Q9WV93 (/IGI) |
|
Negative regulation of transcription by transcription factor localization GO:0010621
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor.
|
3 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
3 | Q9QUS4 (/IDA) Q9QUS4 (/IDA) Q9WV93 (/IDA) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
3 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Ascending aorta morphogenesis GO:0035910
The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.
|
3 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Dorsal aorta morphogenesis GO:0035912
The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.
|
3 | Q9QUS4 (/IGI) Q9QUS4 (/IGI) Q9WV93 (/IGI) |
|
Umbilical cord morphogenesis GO:0036304
The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta.
|
3 | Q9QUS4 (/IGI) Q9QUS4 (/IGI) Q9WV93 (/IGI) |
|
Regulation of inner ear auditory receptor cell differentiation GO:0045607
Any process that modulates the frequency, rate or extent of auditory hair cell differentiation.
|
3 | Q9QUS4 (/IGI) Q9QUS4 (/IGI) Q9WV93 (/IGI) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) Q9WV93 (/IMP) |
|
Smooth muscle cell differentiation GO:0051145
The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.
|
3 | Q9UBP5 (/NAS) Q9UBP5 (/NAS) Q9UBP5 (/NAS) |
|
Ventricular cardiac muscle cell development GO:0055015
The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.
|
3 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Cardiac septum morphogenesis GO:0060411
The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.
|
3 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) Q9WV93 (/IMP) |
|
Atrial septum morphogenesis GO:0060413
The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another.
|
3 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Negative regulation of transcription initiation from RNA polymerase II promoter GO:0060633
Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.
|
3 | Q9UBP5 (/IDA) Q9UBP5 (/IDA) Q9UBP5 (/IDA) |
|
Labyrinthine layer blood vessel development GO:0060716
The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.
|
3 | Q9QUS4 (/IGI) Q9QUS4 (/IGI) Q9WV93 (/IGI) |
|
Artery development GO:0060840
The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed.
|
3 | Q9QUS4 (/IGI) Q9QUS4 (/IGI) Q9WV93 (/IGI) |
|
Arterial endothelial cell differentiation GO:0060842
The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries.
|
3 | Q9QUS4 (/IGI) Q9QUS4 (/IGI) Q9WV93 (/IGI) |
|
Pulmonary artery morphogenesis GO:0061156
The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs.
|
3 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Negative regulation of biomineral tissue development GO:0070168
Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.
|
3 | Q9QUS4 (/IDA) Q9QUS4 (/IDA) Q9WV93 (/IDA) |
|
Vascular smooth muscle cell development GO:0097084
The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.
|
3 | Q9UBP5 (/IEP) Q9UBP5 (/IEP) Q9UBP5 (/IEP) |
|
Negative regulation of transcription regulatory region DNA binding GO:2000678
Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding.
|
3 | Q9QUS4 (/ISO) Q9QUS4 (/ISO) Q9WV93 (/ISO) |
|
Negative regulation of cardiac vascular smooth muscle cell differentiation GO:2000723
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation.
|
3 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation GO:2000820
Any negative regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation.
|
3 | Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) |
|
Regulation of vasculogenesis GO:2001212
Any process that modulates the frequency, rate or extent of vasculogenesis.
|
3 | Q9QUS4 (/IGI) Q9QUS4 (/IGI) Q9WV93 (/IGI) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q9QUS4 (/IGI) Q9QUS4 (/IGI) |
|
Muscular septum morphogenesis GO:0003150
The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Outflow tract morphogenesis GO:0003151
The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
|
2 | Q9DBX7 (/IGI) Q9WV93 (/IGI) |
|
Outflow tract morphogenesis GO:0003151
The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Atrioventricular valve development GO:0003171
The progression of the atrioventricular valve over time, from its formation to the mature structure.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Atrioventricular valve morphogenesis GO:0003181
The process in which the structure of the atrioventricular valve is generated and organized.
|
2 | Q9DBX7 (/IGI) Q9WV93 (/IGI) |
|
Pulmonary valve morphogenesis GO:0003184
The process in which the structure of the pulmonary valve is generated and organized.
|
2 | Q9DBX7 (/IGI) Q9WV93 (/IGI) |
|
Pulmonary valve morphogenesis GO:0003184
The process in which the structure of the pulmonary valve is generated and organized.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Tricuspid valve morphogenesis GO:0003186
The process in which the structure of the tricuspid valve is generated and organized.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Tricuspid valve formation GO:0003195
The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198
A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion.
|
2 | Q9DBX7 (/IGI) Q9WV93 (/IGI) |
|
Endocardial cushion morphogenesis GO:0003203
The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
|
2 | Q9DBX7 (/IGI) Q9WV93 (/IGI) |
|
Cardiac left ventricle morphogenesis GO:0003214
The process in which the left cardiac ventricle is generated and organized.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Cardiac right ventricle morphogenesis GO:0003215
The process in which the right cardiac ventricle is generated and organized.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Cardiac muscle hypertrophy GO:0003300
The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q9I8A3 (/IMP) Q9I8A3 (/IMP) |
|
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q9DBX7 (/TAS) Q9WV93 (/TAS) |
|
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
|
2 | Q9QUS4 (/IGI) Q9QUS4 (/IGI) |
|
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Positive regulation of heart rate GO:0010460
Any process that activates or increases the frequency or rate of heart contraction.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Negative regulation of cardiac muscle cell apoptotic process GO:0010667
Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Mesenchymal cell development GO:0014031
The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
|
2 | Q9DBX7 (/IGI) Q9WV93 (/IGI) |
|
Mesenchymal cell development GO:0014031
The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Cardiac muscle hypertrophy in response to stress GO:0014898
The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis.
|
2 | Q9QUS4 (/IDA) Q9QUS4 (/IDA) |
|
Adenohypophysis development GO:0021984
The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus.
|
2 | Q8AXV6 (/IMP) Q8AXV6 (/IMP) |
|
Floor plate development GO:0033504
The progression of the floor plate over time from its initial formation until its mature state.
|
2 | Q9I8A3 (/IMP) Q9I8A3 (/IMP) |
|
Ascending aorta morphogenesis GO:0035910
The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Cell fate commitment GO:0045165
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q9DBX7 (/IGI) Q9WV93 (/IGI) |
|
Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
|
2 | Q9I8A3 (/IMP) Q9I8A3 (/IMP) |
|
Ventricular cardiac muscle cell development GO:0055015
The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Positive regulation of cardiac muscle cell proliferation GO:0060045
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Cardiac epithelial to mesenchymal transition GO:0060317
A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
2 | Q9DBX7 (/IGI) Q9WV93 (/IGI) |
|
Cardiac epithelial to mesenchymal transition GO:0060317
A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Heart trabecula formation GO:0060347
The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Ventricular septum morphogenesis GO:0060412
The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.
|
2 | Q9DBX7 (/IGI) Q9WV93 (/IGI) |
|
Ventricular septum morphogenesis GO:0060412
The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Atrial septum morphogenesis GO:0060413
The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Negative regulation of transcription initiation from RNA polymerase II promoter GO:0060633
Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.
|
2 | Q9QUS4 (/ISO) Q9QUS4 (/ISO) |
|
Cardiac vascular smooth muscle cell development GO:0060948
The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Coronary vasculature morphogenesis GO:0060977
The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Pulmonary artery morphogenesis GO:0061156
The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Protein-DNA complex assembly GO:0065004
The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.
|
2 | Q9QUS4 (/IDA) Q9QUS4 (/IDA) |
|
Glomus development GO:0072013
The progression of the glomus over time from its initial formation until its mature state. The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment.
|
2 | Q9I8A3 (/IMP) Q9I8A3 (/IMP) |
|
Specification of proximal tubule identity GO:0072082
The process in which the proximal tubule of the kidney nephron acquires its identity.
|
2 | Q9I8A3 (/IMP) Q9I8A3 (/IMP) |
|
Proximal/distal pattern formation involved in pronephric nephron development GO:0072196
The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of the pronephros.
|
2 | Q9I8A3 (/IMP) Q9I8A3 (/IMP) |
|
Cochlea development GO:0090102
The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.
|
2 | Q9QUS4 (/IGI) Q9QUS4 (/IGI) |
|
Cochlea development GO:0090102
The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.
|
2 | Q9QUS4 (/IMP) Q9QUS4 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q66KK8 (/ISS) |
|
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
|
1 | Q9I9L0 (/IMP) |
|
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
|
1 | Q9I9L0 (/IMP) |
|
Osteoblast development GO:0002076
The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.
|
1 | Q9WV93 (/IGI) |
|
Atrioventricular valve morphogenesis GO:0003181
The process in which the structure of the atrioventricular valve is generated and organized.
|
1 | Q9NQ87 (/ISS) |
|
Atrioventricular valve formation GO:0003190
The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
|
1 | Q9WV93 (/IMP) |
|
Epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198
A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion.
|
1 | Q9NQ87 (/ISS) |
|
Positive regulation of transcription of Notch receptor target GO:0007221
The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain.
|
1 | Q9NQ87 (/TAS) |
|
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
|
1 | Q9DBX7 (/NAS) |
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Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
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1 | G3V7S6 (/IEP) |
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Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
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1 | Q9I9L0 (/IMP) |
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Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
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1 | Q9WV93 (/IDA) |
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Glomerulus development GO:0032835
The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.
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1 | Q9DBX7 (/IEP) |
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Floor plate development GO:0033504
The progression of the floor plate over time from its initial formation until its mature state.
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1 | Q66KK8 (/ISS) |
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Dorsal aorta morphogenesis GO:0035912
The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.
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1 | Q9I9L0 (/IMP) |
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Skeletal muscle cell differentiation GO:0035914
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
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1 | Q9DBX7 (/IMP) |
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Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
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1 | Q9NQ87 (/IDA) |
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Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
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1 | Q9DBX7 (/ISO) |
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Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
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1 | Q9DBX7 (/ISS) |
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Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
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1 | Q9WV93 (/IMP) |
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Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
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1 | Q9DBX7 (/IDA) |
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Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
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1 | Q9DBX7 (/IMP) |
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Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
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1 | Q9NQ87 (/ISS) |
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Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
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1 | Q9WV93 (/IGI) |
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Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
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1 | Q9WV93 (/ISO) |
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Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
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1 | Q9I9L0 (/IGI) |
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Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
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1 | Q66KK8 (/ISS) |
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Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
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1 | Q9NQ87 (/IDA) |
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Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
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1 | Q9DBX7 (/ISO) |
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Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
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1 | Q9I9L0 (/IMP) |
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Neuron fate determination GO:0048664
The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed.
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1 | Q7KM13 (/IMP) |
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Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
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1 | Q66KK8 (/ISS) |
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Artery morphogenesis GO:0048844
The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.
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1 | Q9I9L0 (/IMP) |
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Regulation of epithelial cell proliferation GO:0050678
Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
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1 | Q9WV93 (/IGI) |
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Inner ear receptor cell stereocilium organization GO:0060122
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells.
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1 | Q9WV93 (/IGI) |
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Ureteric bud morphogenesis GO:0060675
The process in which the ureteric bud is generated and organized.
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1 | Q9WV93 (/IEP) |
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Negative regulation of androgen receptor signaling pathway GO:0060766
Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
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1 | Q9NQ87 (/IDA) |
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Negative regulation of androgen receptor signaling pathway GO:0060766
Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
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1 | Q9DBX7 (/ISO) |
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Negative regulation of androgen receptor signaling pathway GO:0060766
Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
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1 | Q9DBX7 (/ISS) |
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Artery development GO:0060840
The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed.
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1 | Q9I9L0 (/IMP) |
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Notch signaling pathway involved in arterial endothelial cell fate commitment GO:0060853
The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the commitment of a cell to an arterial endothelial cell fate.
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1 | Q9I9L0 (/IMP) |
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Cellular response to BMP stimulus GO:0071773
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus.
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1 | Q9DBX7 (/IEP) |
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Glomus development GO:0072013
The progression of the glomus over time from its initial formation until its mature state. The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment.
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1 | Q66KK8 (/ISS) |
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Proximal tubule development GO:0072014
The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology.
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1 | Q9DBX7 (/IEP) |
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Comma-shaped body morphogenesis GO:0072049
The process in which the comma-shaped body is generated and organized. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron.
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1 | Q9WV93 (/IEP) |
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S-shaped body morphogenesis GO:0072050
The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron.
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1 | Q9WV93 (/IEP) |
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Specification of proximal tubule identity GO:0072082
The process in which the proximal tubule of the kidney nephron acquires its identity.
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1 | Q66KK8 (/ISS) |
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Renal vesicle development GO:0072087
The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells.
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1 | Q9WV93 (/IEP) |
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Establishment of epithelial cell polarity GO:0090162
The specification and formation of anisotropic intracellular organization of an epithelial cell.
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1 | Q9WV93 (/IGI) |
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Negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation GO:2000820
Any negative regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation.
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1 | Q9WV93 (/ISO) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
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14 |
D3ZNI5 (/TAS)
G3V7S6 (/TAS)
Q9DBX7 (/TAS)
Q9NQ87 (/TAS)
Q9QUS4 (/TAS)
Q9QUS4 (/TAS)
Q9UBP5 (/TAS)
Q9UBP5 (/TAS)
Q9UBP5 (/TAS)
Q9WV93 (/TAS)
(4 more) |
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Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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11 |
Q66KK8 (/ISS)
Q7KM13 (/ISS)
Q9DBX7 (/ISS)
Q9UBP5 (/ISS)
Q9UBP5 (/ISS)
Q9UBP5 (/ISS)
Q9WV93 (/ISS)
Q9Y5J3 (/ISS)
Q9Y5J3 (/ISS)
Q9Y5J3 (/ISS)
(1 more) |
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Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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8 | G3V7S6 (/IDA) Q7KM13 (/IDA) Q9I8A3 (/IDA) Q9I8A3 (/IDA) Q9NQ87 (/IDA) Q9QUS4 (/IDA) Q9QUS4 (/IDA) Q9WV93 (/IDA) |
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Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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8 | Q9NQ87 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9UBP5 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) Q9Y5J3 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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4 | Q9DBX7 (/ISO) Q9QUS4 (/ISO) Q9QUS4 (/ISO) Q9WV93 (/ISO) |
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Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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4 | Q9DBX7 (/IDA) Q9QUS4 (/IDA) Q9QUS4 (/IDA) Q9WV93 (/IDA) |
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Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
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3 | Q9DBX7 (/ISS) Q9QUS4 (/ISS) Q9QUS4 (/ISS) |
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Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
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3 | Q9UBP5 (/IDA) Q9UBP5 (/IDA) Q9UBP5 (/IDA) |
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Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
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2 | Q9QUS4 (/ISO) Q9QUS4 (/ISO) |