The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Helix-loop-helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1647
3D
2ql2C00 - 82.4
2
1394 - - 89.3
3
1290
3D
6g1lA00 - 76.9
4
891 - - 91.4
5
808
3D
1mdyD00 - 90.0
6
771
3D
2ql2D00 - 73.4
7
730 - - 80.5
8
724 - - 91.8
9
686 - - 86.0
10
668 - - 86.4
11
608 - - 57.8
12
583 - - 76.7
13
561
3D
4f3lA01 - 85.7
14
484
3D
1nlwD00 - 74.7
15
472
3D
2ypbA00 - 82.0
16
471
3D
1am9D00 - 77.5
17
446 - - 84.8
18
442
3D
4f3lB01 - 71.4
19
427
3D
5i50B00 - 98.9
20
344 - - 68.9
23
316
3D
5eyoC00 - 78.8
21
315 - - 82.4
22
308 - - 86.8
24
290 - - 71.1
25
282 - - 70.7
26
281 - - 66.0
27
279 - - 63.3
28
275 - - 93.8
29
257 - - 83.5
30
256 - - 64.5
31
233 - - 61.7
32
223 - - 82.1
33
220 - - 87.4
34
217 - - 83.1
35
214 - - 73.6
36
212 - - 71.4
37
199 - - 77.2
38
192 - - 74.4
39
189
3D
2lfhB00 - 82.1
40
175 - - 80.1
41
169 - - 72.8
42
165 - - 50.9
43
163 - - 31.0
44
157 - - 58.5
45
153 - - 39.4
46
143 - - 81.4
47
141 - - 68.0
49
131
3D
1hloB00 - 24.7
48
129 - - 79.9
50
128 - - 69.1
51
115 - - 85.9
52
114 - - 88.6
53
113 - - 73.0
54
112 - - 80.3
55
109
3D
4ayaB00 - 49.3
56
106 - - 57.6
58
100 - - 64.8
57
100 - - 86.9
59
100 - - 75.2
60
95 - - 69.4
61
88 - - 69.0
62
88 - - 85.9
63
86 - - 88.8
64
85 - - 66.7
65
81 - - 50.7
66
80 - - 72.7
67
76 - - 23.1
68
70 - - 78.0
69
65 - - 78.4
70
63 - - 79.1
71
61 - - 73.2
72
52 - - 44.7
74
51 - - 91.4
73
51 - - 42.4
75
48 - - 79.3
76
47 - - 69.0
77
45 - - 77.5
78
44 - - 66.0
79
43 - - 77.8
80
41 - - 88.3
82
40 - - 66.2
81
40 - - 85.3
83
40 - - 72.2
85
37 - - 91.9
86
37 - - 73.7
84
37 - - 43.3
87
36 - - 63.1
89
35 - - 70.4
88
35 - - 23.1
90
32 - - 82.8
99
31
3D
1a0aB00 - 76.3
91
30 - - 35.1
92
30 - - 36.7
94
30 - - 67.5
93
30 - - 56.0
96
BHLH
29 - - 82.3
95
29 - - 73.2
98
29 - - 69.8
97
29 - - 57.2
101
27 - - 52.9
102
27 - - 58.5
100
27 - - 59.2
104
25 - - 80.5
103
25 - - 87.3
105
24 - - 67.2
106
22 - - 27.7
107
22 - - 38.3
108
21 - - 29.3
109
19 - - 75.2
110
19 - - 0.0
112
18 - - 72.3
111
Hpa3
18 - - 52.0
113
17 - - 22.6
114
17 - - 75.5
116
14 - - 73.8
115
14 - - 36.5
117
13 - - 63.0
120
13 - - 13.6
121
13 - - 4.1
119
13 - - 11.9
122
13 - - 25.9
118
13 - - 70.1
124
12 - - 5.4
123
12 - - 52.9
127
11 - - 60.6
128
11 - - 42.4
132
11 - - 61.7
129
Penr2
11 - - 11.1
131
11 - - 3.8
130
11 - - 16.2
125
11 - - 30.4
126
11 - - 45.5
135
10 - - 22.7
133
10 - - 51.1
134
10 - - 41.1
136
9 - - 71.0
137
9 - - 69.5
139
9 - - 0.0
138
BHLH
9 - - 55.7
140
9 - - 11.1
142
8 - - 40.8
145
8 - - 67.2
141
BHLH
8 - - 36.1
144
8 - - 14.0
143
8 - - 13.1
147
activating enhancer binding protein 4
7 - - 7.5
146
7 - - 70.1
149
6 - - 10.8
152
6 - - 11.2
148
BHLH
6 - - 43.9
151
6 - - 41.6
150
6 - - 14.1
153
5 - - 29.6
155
5 - - 23.2
154
5 - - 30.3
156
5 - - 41.4
158
4 - - 43.2
165
4 - - 41.0
161
4 - - 6.8
157
4 - - 27.6
164
4 - - 12.8
160
4 - - 13.6
163
4 - - 14.3
159
BHLH
4 - - 0.0
162
4 - - 0.0
180
3 - - 36.7
170
3 - - 12.2
175
3 - - 0.0
181
3 - - 41.3
168
3 - - 4.8
178
3 - - 0.0
174
3 - - 0.0
183
3 - - 30.4
179
3 - - 0.0
177
3 - - 19.9
182
3 - - 31.1
167
3 - - 8.6
173
3 - - 7.2
171
3 - - 7.3
176
3 - - 11.6
169
3 - - 5.6
172
BHLH
3 - - 1.3
166
3 - - 27.1
191
2 - - 0.0
187
2 - - 0.0
198
2 - - 38.1
202
2 - - 46.1
184
2 - - 17.1
200
2 - - 0.0
192
2 - - 0.0
199
2 - - 0.0
195
2 - - 9.3
188
2 - - 0.0
203
2 - - 48.0
204
2 - - 53.6
193
2 - - 0.0
189
2 - - 0.0
186
2 - - 7.7
196
2 - - 0.0
194
2 - - 0.0
197
2 - - 29.6
201
2 - - 0.0
190
2 - - 5.9
185
2 - - 10.5
246
1 - - 0.0
212
1 - - 0.0
232
1 - - 0.0
225
1 - - 0.0
207
1 - - 0.0
229
1 - - 0.0
222
1 - - 0.0
217
1 - - 0.0
247
1 - - 0.0
209
1 - - 0.0
210
1 - - 0.0
242
1 - - 0.0
213
1 - - 0.0
224
1 - - 0.0
233
1 - - 0.0
243
1 - - 0.0
228
1 - - 0.0
238
1 - - 0.0
248
1 - - 0.0
211
1 - - 0.0
236
1 - - 0.0
218
1 - - 0.0
234
1 - - 0.0
221
1 - - 0.0
205
1 - - 0.0
227
1 - - 0.0
240
1 - - 0.0
230
1 - - 0.0
214
1 - - 0.0
239
1 - - 0.0
219
1 - - 0.0
206
1 - - 0.0
220
1 - - 0.0
226
1 - - 0.0
244
1 - - 0.0
237
1 - - 0.0
235
1 - - 0.0
215
1 - - 0.0
245
1 - - 0.0
208
1 - - 0.0
241
1 - - 0.0
231
1 - - 0.0
223
1 - - 0.0
216
1 - - 0.0