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CATH Superfamily 3.90.79.10

Nucleoside Triphosphate Pyrophosphohydrolase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleoside Triphosphate Pyrophosphohydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 101: U8 snoRNA-decapping enzyme

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase. [EC: 3.6.1.62]
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] + H(2)O = N(7)- methylguanosine 5'-diphosphate + 5'-phospho-[mRNA].
  • Decapping of mRNA is a critical step in eukaryotic mRNA turnover.
  • The enzyme is unable to cleave a free cap structure (m(7)GpppG).
  • The enzyme from Vaccinia virus is synergistically activated in the presence of Mg(2+) and Mn(2+).
  • Formerly EC 3.6.1.30.
 4 A0A1L8F6T2 A0A1L8F6T2 Q6TEC1 Q6TEC1
Inosine diphosphate phosphatase. [EC: 3.6.1.64]
(1) IDP + H(2)O = IMP + phosphate. (2) dIDP + H(2)O = dIMP + phosphate.
  • The human enzyme also hydrolyzes GDP and dGDP, and to a lesser extent ITP, dITP and XTP.
 4 A0A1L8F6T2 A0A1L8F6T2 Q6TEC1 Q6TEC1