The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Serine/threonine-protein phosphatase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
196 A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS)
(186 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
193 A6H772 (/IPI) A6H772 (/IPI) A6H772 (/IPI) A6H772 (/IPI) A6H772 (/IPI) A6H772 (/IPI) A6H772 (/IPI) A6H772 (/IPI) A6H772 (/IPI) A6H772 (/IPI)
(183 more)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
129 P48529 (/IDA) P48529 (/IDA) P60510 (/IDA) P60510 (/IDA) P60510 (/IDA) P60510 (/IDA) P60510 (/IDA) P60510 (/IDA) P60510 (/IDA) P60510 (/IDA)
(119 more)
NF-kappaB-inducing kinase activity GO:0004704
Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK).
126 P60510 (/NAS) P60510 (/NAS) P60510 (/NAS) P60510 (/NAS) P60510 (/NAS) P60510 (/NAS) P60510 (/NAS) P60510 (/NAS) P60510 (/NAS) P60510 (/NAS)
(116 more)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
126 P60510 (/NAS) P60510 (/NAS) P60510 (/NAS) P60510 (/NAS) P60510 (/NAS) P60510 (/NAS) P60510 (/NAS) P60510 (/NAS) P60510 (/NAS) P60510 (/NAS)
(116 more)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
63 P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO)
(53 more)
Lamin binding GO:0005521
Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope.
63 P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO)
(53 more)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
63 P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO)
(53 more)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
63 P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO)
(53 more)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
2 O76932 (/IMP) O76932 (/IMP)
Lamin binding GO:0005521
Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope.
1 Q5BJ92 (/IDA)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 Q5BJ92 (/IDA)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q5BJ92 (/IDA)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
191 A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS) A6H772 (/ISS)
(181 more)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
63 A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA)
(53 more)
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
63 P60510 (/IMP) P60510 (/IMP) P60510 (/IMP) P60510 (/IMP) P60510 (/IMP) P60510 (/IMP) P60510 (/IMP) P60510 (/IMP) P60510 (/IMP) P60510 (/IMP)
(53 more)
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
63 P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO)
(53 more)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
63 P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO)
(53 more)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
3 A8WGP3 (/IMP) A8WGP3 (/IMP) A9JRC7 (/IMP)
Determination of ventral identity GO:0048264
The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
3 A8WGP3 (/IMP) A8WGP3 (/IMP) A9JRC7 (/IMP)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
2 O76932 (/IMP) O76932 (/IMP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 A8WGP3 (/IMP) A8WGP3 (/IMP)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
2 O76932 (/IMP) O76932 (/IMP)
Microtubule-based process GO:0007017
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
2 O76932 (/IMP) O76932 (/IMP)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
2 O76932 (/IMP) O76932 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 A8WGP3 (/IMP) A8WGP3 (/IMP)
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
2 A8WGP3 (/IMP) A8WGP3 (/IMP)
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
2 O76932 (/IGI) O76932 (/IGI)
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
2 O76932 (/IMP) O76932 (/IMP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
1 Q9XW79 (/IGI)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
1 A9JRC7 (/IGI)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
1 Q5BJ92 (/IDA)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
1 Q9XW79 (/ISS)
Positive regulation of BMP signaling pathway GO:0030513
Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
1 A9JRC7 (/IMP)
Regulation of sorocarp development GO:0031156
Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum.
1 Q9Y0B7 (/IGI)
Regulation of sorocarp development GO:0031156
Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum.
1 Q9Y0B7 (/IMP)
Regulation of chemotaxis GO:0050920
Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
1 Q9Y0B7 (/IGI)
Chiasma assembly GO:0051026
The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids.
1 Q9XW79 (/IMP)
Meiotic cell cycle GO:0051321
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
1 Q9XW79 (/IMP)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 Q5BJ92 (/IEP)
Regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination GO:1905261
Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination.
1 Q9XW79 (/IMP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
196 A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA)
(186 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
130 A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA)
(120 more)
Protein phosphatase 4 complex GO:0030289
A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits.
129 A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA) A6H772 (/IDA)
(119 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
126 A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA) A0A024R625 (/IDA)
(116 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
69 O76932 (/IDA) O76932 (/IDA) P48529 (/IDA) P48529 (/IDA) P97470 (/IDA) P97470 (/IDA) P97470 (/IDA) P97470 (/IDA) P97470 (/IDA) P97470 (/IDA)
(59 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
63 P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO)
(53 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
63 P60510 (/TAS) P60510 (/TAS) P60510 (/TAS) P60510 (/TAS) P60510 (/TAS) P60510 (/TAS) P60510 (/TAS) P60510 (/TAS) P60510 (/TAS) P60510 (/TAS)
(53 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
63 P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO)
(53 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
63 P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO) P97470 (/ISO)
(53 more)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
3 O76932 (/IDA) O76932 (/IDA) Q9XW79 (/IDA)
Chromosome, centromeric region GO:0000775
The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
2 O76932 (/IPI) O76932 (/IPI)