The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
DD-peptidase/beta-lactamase superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: D-alanyl-D-alanine serine-type carboxypeptidase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Serine-type D-Ala-D-Ala carboxypeptidase. [EC: 3.4.16.4]
Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
  • A group of bacterial enzymes, membrane-bound.
  • Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme.
  • Distinct from EC 3.4.17.14.
  • Belongs to peptidase families S11, S12 and S13.
20167 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4
(20157 more...)
Beta-lactamase. [EC: 3.5.2.6]
A beta-lactam + H(2)O = a substituted beta-amino acid.
  • Zinc is only requires in class-B enzymes.
  • A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins.
  • Formerly EC 3.5.2.8.
19182 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4 A0A023YTJ4
(19172 more...)