The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 29: 4-aminobutyrate aminotransferase, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
6 P50554 (/ISS) P61922 (/ISS) P80147 (/ISS) Q55FI1 (/ISS) Q9BGI0 (/ISS) Q9BGI0 (/ISS)
Succinate-semialdehyde dehydrogenase binding GO:0032145
Interacting selectively and non-covalently with succinate-semialdehyde dehydrogenase.
4 P50554 (/ISS) P61922 (/ISS) P80404 (/ISS) P80404 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 P50554 (/ISS) P61922 (/ISS) P80147 (/ISS) Q55FI1 (/ISS)
4-aminobutyrate transaminase activity GO:0003867
Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.
3 Q55FI1 (/ISS) Q8MYV0 (/ISS) Q9VW68 (/ISS)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
3 P80147 (/IDA) P80404 (/IDA) P80404 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 P80147 (/IPI) P80404 (/IPI) P80404 (/IPI)
4-aminobutyrate transaminase activity GO:0003867
Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.
2 P17649 (/IMP) P17649 (/IMP)
4-aminobutyrate transaminase activity GO:0003867
Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.
2 A0A1D8PH55 (/NAS) A0A1D8PH55 (/NAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q9BGI0 (/NAS) Q9BGI0 (/NAS)
4-aminobutyrate transaminase activity GO:0003867
Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.
1 P50554 (/IDA)
4-aminobutyrate transaminase activity GO:0003867
Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.
1 P61922 (/ISO)
4-aminobutyrate transaminase activity GO:0003867
Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.
1 P14010 (/RCA)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
1 P61922 (/ISO)
Succinate-semialdehyde dehydrogenase binding GO:0032145
Interacting selectively and non-covalently with succinate-semialdehyde dehydrogenase.
1 P80147 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P61922 (/ISO)

There are 58 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Behavioral response to cocaine GO:0048148
Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.
6 P50554 (/ISS) P80147 (/ISS) P80404 (/ISS) P80404 (/ISS) Q9BGI0 (/ISS) Q9BGI0 (/ISS)
Gamma-aminobutyric acid catabolic process GO:0009450
The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.
4 P50554 (/IC) P80147 (/IC) Q9BGI0 (/IC) Q9BGI0 (/IC)
Neurotransmitter catabolic process GO:0042135
The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
4 P50554 (/IC) P80147 (/IC) Q9BGI0 (/IC) Q9BGI0 (/IC)
Gamma-aminobutyric acid catabolic process GO:0009450
The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.
3 P14010 (/IMP) P17649 (/IMP) P17649 (/IMP)
Regulation of carbohydrate metabolic process GO:0006109
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.
2 Q8MYV0 (/IMP) Q9VW68 (/IMP)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
2 Q8MYV0 (/ISS) Q9VW68 (/ISS)
Gamma-aminobutyric acid catabolic process GO:0009450
The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.
2 P80404 (/NAS) P80404 (/NAS)
Neurotransmitter catabolic process GO:0042135
The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
2 P80404 (/NAS) P80404 (/NAS)
Regulation of circadian sleep/wake cycle GO:0042749
Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle.
2 Q8MYV0 (/IMP) Q9VW68 (/IMP)
Regulation of glutamate metabolic process GO:2000211
Any process that modulates the frequency, rate or extent of glutamate metabolic process.
2 Q8MYV0 (/IMP) Q9VW68 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P50554 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P61922 (/ISO)
Glutamate decarboxylation to succinate GO:0006540
The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes.
1 P14010 (/RCA)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 P50554 (/IDA)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 P61922 (/ISO)
Copulation GO:0007620
The act of sexual union between male and female, involving the transfer of sperm.
1 P50554 (/IMP)
Copulation GO:0007620
The act of sexual union between male and female, involving the transfer of sperm.
1 P61922 (/ISO)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
1 P50554 (/IMP)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
1 P61922 (/ISO)
Gamma-aminobutyric acid biosynthetic process GO:0009449
The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.
1 P50554 (/IMP)
Gamma-aminobutyric acid biosynthetic process GO:0009449
The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.
1 P61922 (/ISO)
Response to iron ion GO:0010039
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
1 P50554 (/IDA)
Response to iron ion GO:0010039
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
1 P61922 (/ISO)
Negative regulation of gamma-aminobutyric acid secretion GO:0014053
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid.
1 P50554 (/IMP)
Negative regulation of gamma-aminobutyric acid secretion GO:0014053
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid.
1 P61922 (/ISO)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 P50554 (/IEP)
Positive regulation of heat generation GO:0031652
Any process that activates or increases the rate or extent of heat generation.
1 P50554 (/IMP)
Positive regulation of heat generation GO:0031652
Any process that activates or increases the rate or extent of heat generation.
1 P61922 (/ISO)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 P50554 (/IMP)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 P61922 (/ISO)
Negative regulation of dopamine secretion GO:0033602
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine.
1 P50554 (/IMP)
Negative regulation of dopamine secretion GO:0033602
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine.
1 P61922 (/ISO)
Response to nicotine GO:0035094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
1 P50554 (/IMP)
Response to nicotine GO:0035094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
1 P61922 (/ISO)
Exploration behavior GO:0035640
The specific behavior of an organism in response to a novel environment or stimulus.
1 P50554 (/IMP)
Exploration behavior GO:0035640
The specific behavior of an organism in response to a novel environment or stimulus.
1 P61922 (/ISO)
Response to cocaine GO:0042220
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
1 P50554 (/IMP)
Response to cocaine GO:0042220
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
1 P61922 (/ISO)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P50554 (/IDA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P61922 (/ISO)
Cellular amide catabolic process GO:0043605
The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
1 P14010 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P50554 (/IDA)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P61922 (/ISO)
Negative regulation of blood pressure GO:0045776
Any process in which the force of blood traveling through the circulatory system is decreased.
1 P50554 (/IMP)
Negative regulation of blood pressure GO:0045776
Any process in which the force of blood traveling through the circulatory system is decreased.
1 P61922 (/ISO)
Positive regulation of dopamine metabolic process GO:0045964
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine.
1 P50554 (/IMP)
Positive regulation of dopamine metabolic process GO:0045964
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine.
1 P61922 (/ISO)
Behavioral response to cocaine GO:0048148
Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.
1 P61922 (/IMP)
Positive regulation of uterine smooth muscle contraction GO:0070474
Any process that increases the frequency, rate or extent of uterine smooth muscle contraction.
1 P50554 (/IMP)
Positive regulation of uterine smooth muscle contraction GO:0070474
Any process that increases the frequency, rate or extent of uterine smooth muscle contraction.
1 P61922 (/ISO)
Negative regulation of platelet aggregation GO:0090331
Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
1 P50554 (/IMP)
Negative regulation of platelet aggregation GO:0090331
Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
1 P61922 (/ISO)
Positive regulation of inhibitory postsynaptic potential GO:0097151
Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.
1 P50554 (/IMP)
Positive regulation of inhibitory postsynaptic potential GO:0097151
Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.
1 P61922 (/ISO)
Positive regulation of prolactin secretion GO:1902722
Any process that activates or increases the frequency, rate or extent of prolactin secretion.
1 P50554 (/IMP)
Positive regulation of prolactin secretion GO:1902722
Any process that activates or increases the frequency, rate or extent of prolactin secretion.
1 P61922 (/ISO)
Positive regulation of aspartate secretion GO:1904450
Any process that activates or increases the frequency, rate or extent of aspartate secretion.
1 P50554 (/IMP)
Positive regulation of aspartate secretion GO:1904450
Any process that activates or increases the frequency, rate or extent of aspartate secretion.
1 P61922 (/ISO)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
12 H3BNQ7 (/IDA) H3BRN4 (/IDA) P50554 (/IDA) P80404 (/IDA) P80404 (/IDA) Q55FI1 (/IDA) Q8MYV0 (/IDA) Q9BGI0 (/IDA) Q9BGI0 (/IDA) Q9VW68 (/IDA)
(2 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
7 P50554 (/ISS) P61922 (/ISS) P80147 (/ISS) P80404 (/ISS) P80404 (/ISS) Q8MYV0 (/ISS) Q9VW68 (/ISS)
4-aminobutyrate transaminase complex GO:0032144
A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity.
5 P50554 (/ISS) P61922 (/ISS) Q55FI1 (/ISS) Q9BGI0 (/ISS) Q9BGI0 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 P61922 (/HDA) Q8MYV0 (/HDA) Q9VW68 (/HDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
3 P80147 (/TAS) P80404 (/TAS) P80404 (/TAS)
4-aminobutyrate transaminase complex GO:0032144
A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity.
3 P80147 (/IDA) P80404 (/IDA) P80404 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q8MYV0 (/ISS) Q9VW68 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P17649 (/IDA) P17649 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 Q9BGI0 (/NAS) Q9BGI0 (/NAS)
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
2 A0A1D8PH55 (/IDA) A0A1D8PH55 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P61922 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P80147 (/TAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P50554 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P61922 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P80147 (/TAS)
4-aminobutyrate transaminase complex GO:0032144
A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity.
1 P61922 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P50554 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P61922 (/ISO)