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CATH Superfamily 3.40.630.30

Gcn5-related N-acetyltransferase (GNAT)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 89: Mycothiol acetyltransferase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Mycothiol synthase. [EC: 2.3.1.189]
Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.
  • This enzyme catalyzes the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium.
  • The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs).
  • The enzyme has been purified from Mycobacterium tuberculosis H37Rv.
  • Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate.
 218 A0A045IPZ7 A0A045IPZ7 A0A045IPZ7 A0A045IPZ7 A0A045IPZ7 A0A045IPZ7 A0A045IPZ7 A0A045IPZ7 A0A045IPZ7 A0A045IPZ7
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