The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 28: N-alpha-acetyltransferase 60 isoform X1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
N-terminal methionine N(alpha)-acetyltransferase NatF. [EC: 2.3.1.259]
Acetyl-CoA + an N-terminal-L-methionyl-[transmembrane protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA.
  • N-terminal-acetylases (NATs) catalyze the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein.
  • This irreversible modification neutralizes the positive charge at the N-terminus, makes the N-terminal residue larger and more hydrophobic, and prevents its removal by hydrolysis.
  • NatF is found only in higher eukaryotes, and is absent from yeast.
  • Unlike other Nat systems the enzyme is located in the Golgi apparatus.
  • It faces the cytosolic side of intracellular membranes, and specifically acetylates transmembrane proteins whose N termini face the cytosol.
  • NatF targets N-terminal L-methionine residues attached to Lys, Ser, Val, Leu, Gln, Ile, Tyr and Thr residues.
  • Formerly EC 2.3.1.88.
24 A0A2K6LED9 A0A2K6LED9 A0A2K6LED9 A0A2K6LED9 A0A2K6R3T8 A0A2K6R3T8 A0A2K6R3T8 A0A2K6R3T8 A0A384NYU5 A0A384NYU5
(14 more...)
Histone acetyltransferase. [EC: 2.3.1.48]
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
  • A group of enzymes acetylating histones.
  • Several of the enzymes can also acetylate lysines in other proteins.
24 A0A2K6LED9 A0A2K6LED9 A0A2K6LED9 A0A2K6LED9 A0A2K6R3T8 A0A2K6R3T8 A0A2K6R3T8 A0A2K6R3T8 A0A384NYU5 A0A384NYU5
(14 more...)