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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 25: N-terminal Xaa-Pro-Lys N-methyltransferase 1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Protein N-terminal methyltransferase. [EC: 2.1.1.244]
(1) 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N- (A,S)PK-[protein]. (2) 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl- L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein].
  • This enzyme methylates the N-terminus of target proteins containing the N-terminal motif (Ala/Pro/Ser)-Pro-Lys after the initiator L-methionine is cleaved.
  • When the terminal amino acid is L-proline, the enzyme catalyzes two successive methylations of its alpha-amino group.
  • When the first amino acid is either L-alanine or L-serine, the enzyme catalyzes three successive methylations.
  • The Pro-Lys in positions 2-3 cannot be exchanged for other amino acids.
  • Formerly EC 2.1.1.n5.
 205 A0A024R8E4 A0A024R8E4 A0A024R8E4 A0A024R8E4 A0A024R8E4 A0A024R8E4 A0A024R8E4 A0A024R8E4 A0A024R8E4 A0A024R8E4
(195 more...)
Protein N-terminal monomethyltransferase. [EC: 2.1.1.299]
S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L- homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein].
  • This enzyme methylates the N-terminus of target proteins containing the N-terminal motif (Ala/Pro/Ser)-Pro-Lys after the initiator L-methionine is cleaved.
  • In contrast to EC 2.1.1.244, the protein only adds one methyl group to the N-terminal.
 7 A0A2R8ZYR2 A0A2R8ZYR2 B2RXM4 B8JM82 D3ZVR1 Q5VVY1 Q5VVY1