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CATH Superfamily 3.30.70.660

Pseudouridine synthase I, catalytic domain, C-terminal subdomain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pseudouridine synthase I, catalytic domain, C-terminal subdomain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA pseudouridine(38-40) synthase. [EC: 5.4.99.12]
tRNA uridine(38-40) = tRNA pseudouridine(38-40).
  • The uridylate residues at positions 38, 39 and 40 of nearly all tRNAs are isomerized to pseudouridine.
  • TruA specifically modifies uridines at positions 38, 39, and/or 40 in the anticodon stem loop of tRNAs with highly divergent sequences and structures.
 1375 A0A009SGN5 A0A023P2G1 A0A023PEF1 A0A023Z084 A0A025CED3 A0A026UMM9 A0A059G0H7 A0A059HXG6 A0A059ZM41 A0A062DNL4
(1365 more...)
TRNA pseudouridine(38/39) synthase. [EC: 5.4.99.45]
tRNA uridine(38/39) = tRNA pseudouridine(38/39).
  • The enzyme from Saccharomyces cerevisiae is active only toward uridine(38) and uridine(39), and shows no activity with uridine(40) (cf. EC 5.4.99.12).
  • In vitro the enzyme from mouse is active on uridine(39) and very slightly on uridine(38) (human tRNA(Leu)).
 4 P31115 Q3SX07 Q9BZE2 Q9JI38
Mitochondrial tRNA pseudouridine(27/28) synthase. [EC: 5.4.99.44]
Mitochondrial tRNA uridine(27/28) = mitochondrial tRNA pseudouridine(27/28).
  • The mitochondrial enzyme Pus2p is specific for position 27 or 28 in mitochondrial tRNA.
 2 N1P5H6 P53167