The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Pseudouridine synthase I, catalytic domain, C-terminal subdomain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Pseudouridine synthase I, catalytic domain, C-terminal subdomain

Pseudouridine synthases (psi synthases) are a class of RNA modifying enzymes that catalyze the conversion of uridine to psi in a variety of RNA substrates, without any cofactor. This process is key for translational accuracy and efficiency. psi synthases, based on sequence homology, are grouped into six families all of which share catalytic domains with a common fold containing conserved motifs required for catalytic activity PMID:23707380. Structural domains comprising this superfamily share the structure of the the C-terminal region of the catalytic domain of Pseudouridine synthase I (TruA) which specifically modifies uridines at positions 38, 39 and/or 40 of tRNAs PMID:17466622.

GO Diversity

Unique GO annotations
30 Unique GO terms

EC Diversity

Unique EC annotations
3 Unique EC terms

Species Diversity

Unique species annotations
14065 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 19
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 3
Unique PDBs: 10
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 90
Unique EC: 3
Unique GO: 30
Unique Species: 14065