The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleotide cyclase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Guanylate cyclase soluble subunit alpha-3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ion binding GO:0043167
Interacting selectively and non-covalently with ions, charged atoms or groups of atoms.
6 B2RQD5 (/ISO) B7ZN37 (/ISO) E9Q6H0 (/ISO) Q6XE41 (/ISO) Q8BXH3 (/ISO) Q9ERL9 (/ISO)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
4 Q02108 (/IDA) Q07093 (/IDA) Q07093 (/IDA) Q9WVI4 (/IDA)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
3 P19686 (/TAS) P33402 (/TAS) Q02108 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P33402 (/IPI) Q02108 (/IPI) Q9WVI4 (/IPI)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
2 F8VQK3 (/ISO) Q9ERL9 (/ISO)
Oxygen sensor activity GO:0019826
Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2).
2 O02298 (/IMP) Q6DNF4 (/IMP)
Ion binding GO:0043167
Interacting selectively and non-covalently with ions, charged atoms or groups of atoms.
2 P19686 (/IDA) P22717 (/IDA)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
1 Q6DNF4 (/ISS)
Oxygen binding GO:0019825
Interacting selectively and non-covalently with oxygen (O2).
1 O02298 (/IDA)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 Q02108 (/TAS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P19686 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q9ERL9 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q9WVI4 (/NAS)
Carbon monoxide binding GO:0070025
Interacting selectively and non-covalently with carbon monoxide (CO).
1 O02298 (/IDA)
Nitric oxide binding GO:0070026
Interacting selectively and non-covalently with nitric oxide (NO).
1 O02298 (/IDA)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of nitric oxide mediated signal transduction GO:0010750
Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO).
2 F8VQK3 (/IMP) Q9ERL9 (/IMP)
Rhodopsin mediated signaling pathway GO:0016056
The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response.
2 Q07093 (/IMP) Q07093 (/IMP)
Positive phototaxis GO:0046956
The directed movement of a cell or organism towards a source of light.
2 Q07093 (/IMP) Q07093 (/IMP)
Response to oxygen levels GO:0070482
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.
2 O02298 (/IMP) Q6DNF4 (/IMP)
CGMP biosynthetic process GO:0006182
The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
1 Q02108 (/IDA)
CGMP biosynthetic process GO:0006182
The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
1 Q9ERL9 (/IMP)
CGMP biosynthetic process GO:0006182
The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
1 Q9ERL9 (/ISO)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 P33402 (/TAS)
Nitric oxide mediated signal transduction GO:0007263
Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
1 Q02108 (/TAS)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
1 Q6DNF4 (/IGI)
Chemosensory behavior GO:0007635
Behavior that is dependent upon the sensation of chemicals.
1 P92006 (/IGI)
Chemosensory behavior GO:0007635
Behavior that is dependent upon the sensation of chemicals.
1 P92006 (/IMP)
Blood circulation GO:0008015
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
1 Q02108 (/TAS)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
1 Q9ERL9 (/IMP)
Aerotaxis GO:0009454
The directed movement of a motile cell or organism in response to environmental oxygen.
1 O02298 (/IMP)
Response to herbicide GO:0009635
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.
1 P19686 (/IEP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P19686 (/IEP)
CGMP-mediated signaling GO:0019934
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
1 O02298 (/IMP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 O02298 (/IGI)
Sensory perception of bitter taste GO:0050913
The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
1 P92006 (/IGI)
Sensory perception of bitter taste GO:0050913
The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
1 P92006 (/IMP)
Response to defense-related host nitric oxide production GO:0052565
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 Q9ERL9 (/IMP)
Response to hyperoxia GO:0055093
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.
1 O02298 (/IMP)
Relaxation of vascular smooth muscle GO:0060087
A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity.
1 Q9ERL9 (/IMP)
Inflammatory response to wounding GO:0090594
The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents.
1 E7EZW5 (/IMP)
Retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission GO:0098925
Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.
1 Q9ERL9 (/IDA)
Retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission GO:0098925
Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.
1 Q9ERL9 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Guanylate cyclase complex, soluble GO:0008074
Complex that possesses guanylate cyclase activity and is not bound to a membrane.
4 P19686 (/IDA) Q02108 (/IDA) Q07093 (/IDA) Q07093 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P22717 (/TAS) Q5U330 (/TAS) Q9WVI4 (/TAS)
Guanylate cyclase complex, soluble GO:0008074
Complex that possesses guanylate cyclase activity and is not bound to a membrane.
2 P19686 (/TAS) Q02108 (/TAS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 O02298 (/IDA) Q6DNF4 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 O02298 (/IDA) Q6DNF4 (/IDA)
Guanylate cyclase complex, soluble GO:0008074
Complex that possesses guanylate cyclase activity and is not bound to a membrane.
1 Q9ERL9 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P19686 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9ERL9 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q9ERL9 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q9ERL9 (/IMP)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 Q9ERL9 (/IDA)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 Q9ERL9 (/IMP)