The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleotide cyclase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1049 - - 86.8
2
867
3D
3maaA00 - 74.6
3
623
3D
3maaB00 - 78.1
4
380 - - 85.9
5
274
3D
4ni2B00 - 86.7
6
269 - - 80.8
7
265
3D
4ni2A00 - 89.2
8
253 - - 87.7
9
252 - - 73.9
10
236 - - 37.8
11
232 - - 56.3
12
227 - - 50.0
13
217 - - 79.8
14
216 - - 84.6
15
199 - - 88.0
17
160
3D
5iv4A02 - 97.2
16
154 - - 95.0
18
118 - - 70.5
21
115
3D
5iv4A01 - 96.1
19
99 - - 75.4
20
98 - - 48.9
22
79
3D
1fx2A00 - 94.1
23
77 - - 73.6
24
74 - - 87.1
25
67
3D
3r5gB00 - 56.2
33
65
3D
4p2xB00 - 91.0
26
56 - - 83.6
27
53 - - 82.2
28
52 - - 82.6
29
47 - - 30.5
30
47 - - 90.5
32
46 - - 86.2
31
46 - - 59.5
34
36 - - 21.4
35
34 - - 81.0
36
33 - - 86.1
37
32 - - 41.4
39
32 - - 47.0
38
32 - - 72.5
40
Ca
2+
31 - - 45.5
41
28 - - 73.9
43
24 - - 38.6
42
24 - - 81.3
44
24 - - 65.5
45
23 - - 83.7
46
23 - - 24.9
47
20 - - 0.0
49
19 - - 0.6
48
19 - - 71.6
50
19 - - 87.7
70
19
3D
1ybuD00 - 12.9
52
18 - - 0.6
51
18 - - 8.6
54
18 - - 35.3
53
18 - - 68.5
55
17 - - 92.3
57
15 - - 71.1
58
15 - - 67.4
56
15 - - 83.3
59
15 - - 89.1
76
13
3D
1y11A02 - 9.1
62
13 - - 89.2
61
13 - - 56.5
60
13 - - 31.7
67
12 - - 4.5
64
12 - - 62.5
68
12 - - 23.3
65
12 - - 60.4
63
12 - - 12.2
66
12 - - 76.6
71
ATP pyrophosphate-lyase
11 - - 13.3
69
11 - - 32.5
73
10 - - 58.3
72
10 - - 1.2
74
9 - - 34.6
75
9 - - 45.8
84
8 - - 32.7
77
8 - - 16.5
83
8 - - 46.1
78
8 - - 20.7
81
8 - - 73.5
82
8 - - 77.6
79
8 - - 16.9
80
8 - - 39.7
90
7 - - 66.3
89
7 - - 14.9
91
7 - - 68.5
87
7 - - 72.0
86
7 - - 74.4
88
7 - - 74.8
85
7 - - 15.4
93
6 - - 0.0
96
6 - - 78.8
94
6 - - 66.1
95
6 - - 70.2
92
6 - - 10.9
102
5 - - 16.3
101
5 - - 52.4
104
5 - - 12.4
98
5 - - 7.3
103
5 - - 10.4
97
5 - - 54.8
100
5 - - 10.2
106
5 - - 21.4
99
5 - - 11.6
105
5 - - 45.3
118
4 - - 65.5
114
brain
4 - - 50.6
119
4 - - 36.2
115
4 - - 67.5
113
4 - - 10.9
107
4 - - 84.6
116
4 - - 62.7
109
4 - - 3.6
110
4 - - 1.1
112
4 - - 8.2
117
4 - - 67.3
108
4 - - 20.0
111
4 - - 25.9
127
3 - - 0.0
129
3 - - 0.6
124
3 - - 0.0
131
3 - - 4.4
120
3 - - 29.9
122
3 - - 6.6
132
3 - - 52.4
125
3 - - 31.7
121
3 - - 7.0
126
3 - - 5.0
133
3 - - 57.6
123
ATP pyrophosphate-lyase Adenylyl cyclase
3 - - 0.0
128
3 - - 0.6
134
3 - - 73.3
130
3 - - 7.0
206
2 - - 27.1
194
2 - - 0.0
163
2 - - 0.0
175
2 - - 0.0
199
2 - - 18.2
153
2 - - 7.2
198
2 - - 0.0
139
2 - - 19.7
202
2 - - 33.8
168
2 - - 6.0
184
2 - - 0.0
135
2 - - 35.6
145
2 - - 31.7
178
2 - - 0.7
140
Ca
2+
2 - - 10.8
181
2 - - 0.0
154
2 - - 1.1
159
2 - - 41.4
160
2 - - 39.0
195
2 - - 11.6
193
2 - - 0.0
180
2 - - 1.7
162
2 - - 0.0
201
2 - - 31.4
152
2 - - 0.0
189
2 - - 0.0
174
2 - - 0.0
188
2 - - 0.0
136
2 - - 44.6
144
2 - - 12.0
177
2 - - 0.0
143
2 - - 0.0
205
2 - - 40.4
158
2 - - 38.0
183
2 - - 0.0
169
2 - - 0.0
171
2 - - 0.0
200
2 - - 28.7
190
2 - - 0.0
161
2 - - 0.0
151
2 - - 7.9
148
2 - - 0.0
157
2 - - 33.7
197
2 - - 0.0
203
2 - - 36.4
138
2 - - 20.2
137
2 - - 44.7
204
2 - - 40.5
165
2 - - 0.0
186
2 - - 8.4
147
2 - - 11.3
191
2 - - 0.8
172
2 - - 0.0
187
2 - - 0.0
176
2 - - 0.0
170
2 - - 0.0
179
2 - - 0.0
182
2 - - 0.0
142
2 - - 1.8
167
2 - - 0.0
149
2 - - 0.0
173
2 - - 0.0
166
2 - - 0.0
141
2 - - 0.0
156
2 - - 20.2
192
2 - - 0.0
150
2 - - 0.0
155
2 - - 0.0
185
2 - - 0.0
146
2 - - 41.4
164
2 - - 0.0
196
2 - - 2.8
276
1 - - 0.0
233
1 - - 0.0
259
1 - - 0.0
220
1 - - 0.0
208
1 - - 0.0
226
1 - - 0.0
211
1 - - 0.0
241
1 - - 0.0
280
1 - - 0.0
273
1 - - 0.0
236
1 - - 0.0
249
1 - - 0.0
218
1 - - 0.0
285
1 - - 0.0
234
1 - - 0.0
270
1 - - 0.0
244
1 - - 0.0
246
1 - - 0.0
240
1 - - 0.0
230
1 - - 0.0
266
1 - - 0.0
214
1 - - 0.0
221
1 - - 0.0
229
1 - - 0.0
260
1 - - 0.0
237
1 - - 0.0
222
1 - - 0.0
286
1 - - 0.0
254
1 - - 0.0
217
1 - - 0.0
239
1 - - 0.0
269
1 - - 0.0
281
1 - - 0.0
235
1 - - 0.0
213
1 - - 0.0
265
1 - - 0.0
272
1 - - 0.0
243
1 - - 0.0
231
1 - - 0.0
275
1 - - 0.0
261
1 - - 0.0
284
1 - - 0.0
247
1 - - 0.0
228
1 - - 0.0
268
1 - - 0.0
224
1 - - 0.0
223
1 - - 0.0
282
1 - - 0.0
262
1 - - 0.0
212
1 - - 0.0
238
1 - - 0.0
251
1 - - 0.0
253
1 - - 0.0
279
1 - - 0.0
209
1 - - 0.0
256
1 - - 0.0
216
1 - - 0.0
227
1 - - 0.0
264
1 - - 0.0
255
1 - - 0.0
277
1 - - 0.0
232
1 - - 0.0
225
1 - - 0.0
207
1 - - 0.0
263
1 - - 0.0
210
1 - - 0.0
258
1 - - 0.0
274
1 - - 0.0
252
1 - - 0.0
283
1 - - 0.0
250
1 - - 0.0
215
1 - - 0.0
278
1 - - 0.0
271
1 - - 0.0
245
1 - - 0.0
267
1 - - 0.0
219
1 - - 0.0
257
1 - - 0.0
248
1 - - 0.0
242
1 - - 0.0