The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleotide cyclase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Guanylate cyclase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
15 P16066 (/IDA) P16066 (/IDA) P18293 (/IDA) P18293 (/IDA) P18910 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA)
(5 more)
Natriuretic peptide receptor activity GO:0016941
Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
12 P16066 (/IDA) P16066 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA)
(2 more)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
11 P18293 (/IMP) P18293 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP)
(1 more)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
11 P16066 (/IPI) P16066 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI)
(1 more)
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
11 P16066 (/IPI) P16066 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI)
(1 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 P18910 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI)
Natriuretic peptide receptor activity GO:0016941
Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
9 P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
8 C7LAF5 (/ISS) M9NFA6 (/ISS) P46197 (/ISS) P55202 (/ISS) Q8IQK2 (/ISS) Q961R7 (/ISS) Q9VF17 (/ISS) Q9VU79 (/ISS)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
6 C7LAF5 (/ISS) M9NFA6 (/ISS) Q8IQK2 (/ISS) Q961R7 (/ISS) Q9VF17 (/ISS) Q9VU79 (/ISS)
Natriuretic peptide receptor activity GO:0016941
Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
4 P18293 (/ISS) P18293 (/ISS) P46197 (/ISS) P55202 (/ISS)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
3 P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO)
Natriuretic peptide receptor activity GO:0016941
Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
3 P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
3 P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO)
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
3 P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO)
G protein-coupled peptide receptor activity GO:0008528
Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
2 P16066 (/NAS) P16066 (/NAS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 P18293 (/ISO) P18293 (/ISO)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
1 P16067 (/IMP)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P18910 (/IMP)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q6VVW5 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P46197 (/ISS)

There are 43 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
CGMP biosynthetic process GO:0006182
The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
11 P16066 (/IDA) P16066 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA)
(1 more)
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
11 P16066 (/IDA) P16066 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA)
(1 more)
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
11 P16066 (/TAS) P16066 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS)
(1 more)
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
9 P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
9 P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS)
Cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.
9 P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP)
CGMP-mediated signaling GO:0019934
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
6 C7LAF5 (/ISS) M9NFA6 (/ISS) Q8IQK2 (/ISS) Q961R7 (/ISS) Q9VF17 (/ISS) Q9VU79 (/ISS)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
4 C7LAF5 (/IMP) M9NFA6 (/IMP) Q8IQK2 (/IMP) Q9VU79 (/IMP)
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P16067 (/ISS) P46197 (/ISS) P55202 (/ISS) Q6VVW5 (/ISS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
4 C7LAF5 (/IMP) M9NFA6 (/IMP) Q8IQK2 (/IMP) Q9VU79 (/IMP)
Negative regulation of cell size GO:0045792
Any process that reduces cell size.
4 C7LAF5 (/IMP) M9NFA6 (/IMP) Q8IQK2 (/IMP) Q9VU79 (/IMP)
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
4 C7LAF5 (/IMP) M9NFA6 (/IMP) Q8IQK2 (/IMP) Q9VU79 (/IMP)
CGMP biosynthetic process GO:0006182
The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
3 P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO)
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
3 P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO)
Positive regulation of cGMP-mediated signaling GO:0010753
Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
3 P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO)
CGMP-mediated signaling GO:0019934
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
3 P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO)
Cardiac muscle cell proliferation GO:0060038
The expansion of a cardiac muscle cell population by cell division.
3 A0A0G2KGK2 (/IMP) A0A2R8QJI9 (/IMP) Q1LX84 (/IMP)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 P18293 (/ISO) P18293 (/ISO)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 P16066 (/NAS) P16066 (/NAS)
Body fluid secretion GO:0007589
The controlled release of a fluid by a cell or tissue in an animal.
2 P16066 (/TAS) P16066 (/TAS)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
2 P16066 (/NAS) P16066 (/NAS)
Positive regulation of cGMP-mediated signaling GO:0010753
Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
2 P16067 (/IDA) P18910 (/IDA)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
2 P16066 (/TAS) P16066 (/TAS)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
2 P16066 (/NAS) P16066 (/NAS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2 P18293 (/ISO) P18293 (/ISO)
Positive regulation of urine volume GO:0035810
Any process that increases the amount of urine excreted from the body over a unit of time.
2 P16066 (/TAS) P16066 (/TAS)
Positive regulation of renal sodium excretion GO:0035815
Any process that increases the amount of sodium excreted in urine over a unit of time.
2 P16066 (/TAS) P16066 (/TAS)
Dopamine metabolic process GO:0042417
The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
2 P18293 (/ISO) P18293 (/ISO)
Regulation of vascular permeability GO:0043114
Any process that modulates the extent to which blood vessels can be pervaded by fluid.
2 P16066 (/TAS) P16066 (/TAS)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
2 P18293 (/ISO) P18293 (/ISO)
Regulation of blood vessel diameter GO:0097746
Any process that modulates the diameter of blood vessels.
2 P16066 (/NAS) P16066 (/NAS)
CGMP biosynthetic process GO:0006182
The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
1 P46197 (/ISS)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P18910 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q1LX84 (/IMP)
CGMP-mediated signaling GO:0019934
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
1 P16067 (/IDA)
CGMP-mediated signaling GO:0019934
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
1 P18910 (/IMP)
Reproductive process GO:0022414
A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
1 Q6VVW5 (/IMP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P18910 (/IDA)
Dopamine metabolic process GO:0042417
The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
1 P18910 (/IMP)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
1 P18910 (/IMP)
Negative regulation of meiotic cell cycle GO:0051447
Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.
1 Q6VVW5 (/IMP)
Bone development GO:0060348
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
1 Q6VVW5 (/IMP)
Negative regulation of oocyte maturation GO:1900194
Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.
1 Q6VVW5 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 P16066 (/TAS) P16066 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
11 P16067 (/IDA) P18910 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA)
(1 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
10 C7LAF5 (/ISS) M9NFA6 (/ISS) P16067 (/ISS) P46197 (/ISS) P55202 (/ISS) Q6VVW5 (/ISS) Q8IQK2 (/ISS) Q961R7 (/ISS) Q9VF17 (/ISS) Q9VU79 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
9 P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P18293 (/ISO) P18293 (/ISO) Q6VVW5 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P46197 (/ISS) P55202 (/ISS) Q6VVW5 (/ISS)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 P16066 (/IDA) P16066 (/IDA)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 P18293 (/ISO) P18293 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q6VVW5 (/ISO)