CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotide cyclase
Functional Family Guanylate cyclase soluble subunit alpha-3

Enzyme Information

4.6.1.2
Guanylate cyclase.
based on mapping to UniProt Q02108
GTP = 3',5'-cyclic GMP + diphosphate.
-!- Also acts on ITP and dGTP.

UniProtKB Entries (1)

Q02153
GCYB1_HUMAN
Homo sapiens
Guanylate cyclase soluble subunit beta-1

PDB Structure

PDB 4NI2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.
Seeger, F., Quintyn, R., Tanimoto, A., Williams, G.J., Tainer, J.A., Wysocki, V.H., Garcin, E.D.
Biochemistry