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CATH Superfamily 3.30.572.10

Thymidylate synthase/dCMP hydroxymethylase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Thymidylate synthase/dCMP hydroxymethylase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Thymidylate synthase. [EC: 2.1.1.45]
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
    		 1248 A0A009SGJ9 A0A014BAV3 A0A014BQA3 A0A014C2A1 A0A014CEE4 A0A014DAN6 A0A014DUK4 A0A014E2M4 A0A014G2X7 A0A015PXG5
    (1238 more...)
    Dihydrofolate reductase. [EC: 1.5.1.3]
    5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
    • The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate.
    • Formerly EC 1.5.1.4.
    		 43 A0A086KPP3 A0A086KWD1 A0A086LC23 A0A086M605 A0A0G2Y5Q1 A0A0U2UI35 A0A125YXY2 A0A125YXY3 A0A139YB77 A0A140E0U9
    (33 more...)
    Deoxycytidylate 5-hydroxymethyltransferase. [EC: 2.1.2.8]
    5,10-methylenetetrahydrofolate + H(2)O + deoxycytidylate = tetrahydrofolate + 5-hydroxymethyldeoxycytidylate.
      		 8 A0A023ZVP3 A0A097J712 A0A097J7W3 A0A1J0GSG7 P08773 P18029 P18030 S5M707