The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Histidine kinase-like ATPase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Sensor histidine kinase WalK

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
12 O69729 (/IDA) O69729 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA)
(2 more)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
10 P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
10 P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA)
Phosphorelay sensor kinase activity GO:0000155
Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
6 A0A0F7RF92 (/ISS) A0A0F7RF92 (/ISS) A0A0F7RFB4 (/ISS) A0A0F7RFB4 (/ISS) A0A0F7RI94 (/ISS) A0A0F7RI94 (/ISS)
Phosphorelay sensor kinase activity GO:0000155
Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
5 P77485 (/IMP) P77485 (/IMP) P77485 (/IMP) P77485 (/IMP) Q06904 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O69729 (/IPI) O69729 (/IPI) Q06904 (/IPI) Q55168 (/IPI) Q55168 (/IPI)
Phosphorelay sensor kinase activity GO:0000155
Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
4 P77485 (/IDA) P77485 (/IDA) P77485 (/IDA) P77485 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 Q55168 (/IPI) Q55168 (/IPI) Q9RZA4 (/IPI)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
2 O69729 (/IDA) O69729 (/IDA)
Protein histidine kinase activity GO:0004673
Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.
2 Q55168 (/IDA) Q55168 (/IDA)
Red or far-red light photoreceptor activity GO:0009883
The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation.
2 Q55168 (/IDA) Q55168 (/IDA)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
2 O69729 (/IDA) O69729 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 O69729 (/IPI) O69729 (/IPI)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
14 O69729 (/IDA) O69729 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA) P96368 (/IDA)
(4 more)
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
6 A0A0F7RF92 (/ISS) A0A0F7RF92 (/ISS) A0A0F7RFB4 (/ISS) A0A0F7RFB4 (/ISS) A0A0F7RI94 (/ISS) A0A0F7RI94 (/ISS)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
4 P77485 (/IDA) P77485 (/IDA) P77485 (/IDA) P77485 (/IDA)
Signal transduction by protein phosphorylation GO:0023014
A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate.
4 P77485 (/IDA) P77485 (/IDA) P77485 (/IDA) P77485 (/IDA)
Cellular response to copper ion GO:0071280
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
4 P77485 (/IMP) P77485 (/IMP) P77485 (/IMP) P77485 (/IMP)
Cellular response to silver ion GO:0071292
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus.
4 P77485 (/IEP) P77485 (/IEP) P77485 (/IEP) P77485 (/IEP)
Red, far-red light phototransduction GO:0009585
The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm.
2 Q55168 (/IDA) Q55168 (/IDA)
Response to red or far red light GO:0009639
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
2 Q55168 (/IDA) Q55168 (/IDA)
Protein-chromophore linkage GO:0018298
The covalent or noncovalent attachment of a chromophore to a protein.
2 Q55168 (/IDA) Q55168 (/IDA)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P77485 (/IDA) P77485 (/IDA) P77485 (/IDA) P77485 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 P77485 (/NAS) P77485 (/NAS) P77485 (/NAS) P77485 (/NAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 P77485 (/TAS) P77485 (/TAS) P77485 (/TAS) P77485 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O69729 (/HDA) O69729 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O69729 (/HDA) O69729 (/HDA)
Cell septum GO:0030428
A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.
1 E0TZB4 (/IDA)