The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Histidine kinase-like ATPase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1338
3D
6f1nA00 - 91.7
2
1069
3D
4i3hB01 - 81.0
3
738
3D
1nhjA01 - 90.7
4
691
3D
4r1fD01 - 91.8
5
630
3D
4nh9A00 - 93.0
7
469
3D
5m4pA02 - 83.9
6
435
3D
3sl2A00 - 97.1
9
398
3D
2iorA00 - 91.0
8
393
3D
1r62A00 - 71.6
10
342 - - 94.1
11
322
3D
4bizE02 - 91.3
12
308
3D
4x9lA00 - 67.0
13
296 - - 95.5
14
279
3D
3h4lB01 - 88.6
15
260 - - 71.4
16
254
3D
2ch4B01 - 92.6
19
223
3D
1id0A00 - 26.0
18
221
3D
4kp4B02 - 70.1
17
219 - - 97.0
21
218
3D
5tthA01 - 84.4
20
210 - - 46.1
22
191 - - 15.3
23
166 - - 95.2
24
162 - - 75.8
25
161 - - 53.6
26
155 - - 63.0
27
154 - - 79.0
28
151 - - 92.4
29
147 - - 26.8
30
146
3D
4pl9A00 - 92.4
31
144 - - 78.9
32
137 - - 93.3
33
133 - - 71.1
34
132
3D
4p7aA01 - 72.9
35
122 - - 70.4
36
118 - - 38.1
37
117 - - 98.0
38
117 - - 70.9
39
112 - - 1.8
40
112 - - 51.4
42
108
3D
4gczB03 - 94.9
41
108 - - 83.0
43
106 - - 67.1
44
98 - - 92.5
45
97 - - 63.8
46
91 - - 2.9
51
88
3D
4h85A02 - 31.2
47
85 - - 26.4
48
82 - - 20.1
49
81 - - 91.8
50
80 - - 70.3
52
74 - - 17.7
62
72
3D
2zbkH01 - 92.9
53
72 - - 70.0
54
72
3D
3iedA00 - 86.7
55
65
3D
3jz3B01 - 56.2
56
62 - - 21.3
57
61 - - 90.6
58
59 - - 7.9
59
56 - - 30.5
60
54 - - 29.8
61
53 - - 31.6
68
52
3D
1ysrC00 - 32.7
66
51
3D
6blkD00 - 82.7
63
ATP-hydrolyzing
50 - - 83.6
64
49 - - 79.8
67
47 - - 85.2
65
Acetyl-transferring
47 - - 68.4
71
45 - - 31.5
69
45 - - 73.9
70
45 - - 3.9
72
40 - - 27.2
73
34 - - 2.0
76
32 - - 84.0
74
32 - - 40.2
75
32 - - 91.2
77
31 - - 40.2
78
30 - - 93.7
79
29 - - 81.3
80
29 - - 83.4
81
28 - - 16.5
84
27 - - 8.1
82
27 - - 3.2
83
27 - - 71.4
85
26 - - 77.4
87
25 - - 75.3
86
25 - - 45.6
88
ATP-hydrolyzing
24 - - 80.1
90
23 - - 4.7
89
23 - - 57.0
91
23 - - 5.5
92
23 - - 88.0
94
22 - - 60.9
93
22 - - 1.4
95
21 - - 11.9
96
20 - - 35.2
98
20 - - 0.0
99
20 - - 75.0
97
20 - - 80.7
101
19 - - 19.7
100
19 - - 1.6
102
19 - - 1.5
104
19 - - 71.5
103
19 - - 54.9
357
19
3D
5ucjD00 - 13.6
160
18
3D
6mfqB01 - 45.8
107
18 - - 5.1
109
18 - - 75.4
108
18 - - 59.2
106
18 - - 20.8
105
18 - - 49.1
110
17 - - 14.6
112
17 - - 2.2
111
17 - - 27.0
113
16 - - 4.1
116
16 - - 34.0
114
16 - - 42.2
115
16 - - 27.0
118
15 - - 28.7
119
15 - - 0.0
117
15 - - 9.5
124
14 - - 11.1
120
14 - - 11.0
126
14 - - 2.6
327
14
3D
6azrC02 - 5.1
122
14 - - 11.0
125
14 - - 26.4
121
14 - - 9.7
123
14 - - 0.0
127
13 - - 6.9
129
13 - - 6.8
128
13 - - 0.9
130
13 - - 0.0
131
13 - - 44.2
229
13
3D
4fppC02 - 10.6
133
13
3D
4bxiA00 - 6.1
146
13
3D
3zxoB00 - 35.2
139
Mlh3
12 - - 63.7
135
12 - - 18.2
136
12 - - 26.9
235
12
3D
3gigB02 - 12.4
138
12 - - 0.0
137
12 - - 17.0
132
12 - - 7.2
134
12 - - 24.9
145
11 - - 14.6
178
11
3D
3ke6B02 - 3.2
144
11 - - 49.8
142
11 - - 10.4
150
11 - - 56.1
140
11 - - 12.3
143
11 - - 9.0
148
11 - - 7.1
204
11
3D
5fwkB01 - 31.6
147
11 - - 13.6
149
11 - - 71.4
141
11 - - 39.5
153
10 - - 2.8
152
10 - - 0.0
151
10 - - 8.4
155
10 - - 0.8
154
10 - - 90.7
159
10 - - 73.0
230
10
3D
4q20B02 - 5.6
158
10 - - 11.5
157
10 - - 0.0
156
10 - - 0.0
168
9 - - 21.7
180
9 - - 87.4
177
9 - - 1.6
171
9 - - 6.8
161
9 - - 13.7
176
9 - - 55.2
170
9 - - 2.3
167
9 - - 0.0
163
9 - - 48.2
175
9 - - 16.2
162
9 - - 0.0
174
9 - - 17.4
169
9 - - 0.0
165
9 - - 4.5
172
9 - - 7.5
179
9 - - 5.9
173
9 - - 0.7
166
9 - - 11.5
164
9 - - 10.3
194
8 - - 16.5
193
8 - - 6.2
189
8 - - 7.3
200
8 - - 7.3
197
8 - - 0.0
191
8 - - 0.0
187
8 - - 12.4
182
8 - - 11.1
192
8 - - 0.0
199
8 - - 4.3
198
8 - - 0.0
202
8 - - 16.6
184
8 - - 9.2
181
8 - - 0.0
195
8 - - 0.0
201
AFU_orthologue AFUA_4G01020
8 - - 89.2
188
8 - - 44.0
183
8 - - 15.9
190
8 - - 0.8
186
8 - - 4.0
185
8 - - 12.7
196
8 - - 0.0
206
7 - - 14.5
211
7 - - 0.9
205
Lipoamide
7 - - 42.1
213
7 - - 0.0
212
7 - - 0.0
207
7 - - 0.0
215
7 - - 10.3
208
7 - - 0.0
214
7 - - 0.0
217
7 - - 83.9
203
7 - - 0.0
209
7 - - 5.3
216
7 - - 6.4
210
7 - - 0.0
220
6 - - 9.0
226
6 - - 0.0
236
6 - - 18.4
218
6 - - 6.7
234
6 - - 17.1
244
6 - - 81.8
221
6 - - 0.0
237
6 - - 6.4
224
6 - - 0.0
227
6 - - 0.0
232
6 - - 0.0
225
6 - - 0.0
233
6 - - 0.0
241
6 - - 6.3
240
6 - - 20.4
222
6 - - 0.0
239
6 - - 1.5
231
6 - - 0.0
243
6 - - 11.1
228
6 - - 0.0
223
6 - - 8.5
238
6 - - 0.0
219
6 - - 0.0
242
6 - - 12.8
246
5 - - 15.1
260
5 - - 0.0
254
5 - - 11.2
265
5 - - 47.2
262
5 - - 7.1
251
5 - - 0.0
256
5 - - 0.0
264
5 - - 70.3
255
5 - - 0.0
263
5 - - 40.3
250
5 - - 11.6
245
5 - - 0.0
267
5 - - 76.4
257
5 - - 78.9
259
5 - - 12.2
249
5 - - 15.1
266
5 - - 70.7
261
5 - - 15.8
247
5 - - 1.2
268
5 - - 58.1
253
5 - - 7.9
258
5 - - 1.3
252
5 - - 1.6
248
5 - - 5.4
285
4 - - 0.0
288
II
4 - - 20.4
295
4 - - 0.0
300
4 - - 42.8
286
4 - - 9.5
301
4 - - 61.0
296
4 - - 1.3
272
4 - - 8.2
287
4 - - 0.0
294
Acetyl-transferring
4 - - 8.2
275
4 - - 7.9
279
4 - - 0.0
293
4 - - 0.0
274
4 - - 6.7
278
4 - - 0.0
276
4 - - 0.9
292
4 - - 12.7
291
4 - - 0.8
280
4 - - 7.4
273
4 - - 2.8
270
4 - - 65.0
299
4 - - 25.8
302
4 - - 80.5
269
4 - - 1.5
281
4 - - 0.0
298
4 - - 9.5
284
4 - - 0.0
289
4 - - 0.0
282
4 - - 0.8
297
4 - - 10.9
277
4 - - 4.6
290
One component system
4 - - 13.7
283
4 - - 0.8
271
4 - - 66.0
358
3 - - 9.5
331
3 - - 9.7
325
3 - - 0.0
350
3 - - 7.1
337
3 - - 0.0
340
3 - - 6.3
311
3 - - 41.2
348
3 - - 0.7
364
3 - - 25.0
324
3 - - 5.3
351
3 - - 0.0
342
3 - - 0.0
341
3 - - 0.0
312
3 - - 12.5
309
3 - - 14.7
308
3 - - 6.7
329
3 - - 9.6
349
3 - - 8.1
346
3 - - 11.0
333
3 - - 0.0
323
3 - - 0.0
352
3 - - 9.6
359
3 - - 57.1
330
3 - - 0.0
360
3 - - 3.5
322
3 - - 3.2
353
3 - - 3.1
310
3 - - 35.5
303
3 - - 0.0
354
3 - - 2.4
332
3 - - 0.0
316
3 - - 0.0
347
One component system
3 - - 0.0
320
3 - - 4.0
361
Post Meiotic Segregation
3 - - 12.4
307
3 - - 9.8
314
3 - - 9.4
355
3 - - 9.6
326
3 - - 0.0
335
3 - - 0.0
334
3 - - 8.1
315
3 - - 2.4
338
3 - - 5.5
305
3 - - 6.3
328
3 - - 1.3
363
3 - - 3.6
362
3 - - 1.1
317
3 - - 0.0
313
3 - - 10.1
343
3 - - 38.3
321
3 - - 1.3
339
3 - - 6.5
345
3 - - 0.0
319
3 - - 0.0
344
3 - - 39.6
336
3 - - 5.5
304
3 - - 0.8
306
3 - - 4.1
318
3 - - 12.7
356
3 - - 0.0
443
2 - - 10.4
437
2 - - 10.1
463
2 - - 44.0
458
2 - - 35.5
451
2 - - 0.0
454
2 - - 4.6
378
2 - - 16.3
431
2 - - 0.7
382
2 - - 6.5
389
2 - - 7.8
418
Hsp90 family
2 - - 21.1
388
2 - - 0.0
367
2 - - 0.0
391
One-component system
2 - - 0.0
460
2 - - 41.0
453
2 - - 7.8
410
2 - - 7.1
430
2 - - 0.0
447
2 - - 4.4
379
2 - - 0.0
415
2 - - 0.0
452
2 - - 5.8
438
2 - - 0.0
444
2 - - 0.0
417
2 - - 0.0
405
2 - - 0.8
370
2 - - 0.0
416
2 - - 15.8
380
2 - - 0.0
381
2 - - 9.1
392
2 - - 31.4
373
2 - - 0.0
399
2 - - 0.0
436
2 - - 0.0
456
2 - - 0.0
386
2 - - 0.0
445
2 - - 0.0
366
2 - - 12.9
400
2 - - 0.0
441
2 - - 2.5
413
2 - - 3.5
432
2 - - 4.0
427
2 - - 27.0
446
2 - - 4.4
426
Light-regulated signal transduction histidine kinase
2 - - 0.0
369
2 - - 0.0
372
2 - - 0.0
428
2 - - 34.7
414
2 - - 4.3
462
2 - - 43.0
394
2 - - 0.0
393
2 - - 0.0
449
2 - - 1.7
375
2 - - 0.0
387
2 - - 0.0
461
2 - - 38.2
425
2 - - 8.1
368
2 - - 0.0
424
2 - - 0.0
395
2 - - 0.0
434
One-component system
2 - - 0.0
374
2 - - 0.0
442
2 - - 0.0
429
2 - - 12.3
409
2 - - 0.0
412
2 - - 0.0
385
2 - - 8.5
433
2 - - 2.2
440
2 - - 0.0
377
2 - - 0.0
423
2 - - 2.4
422
2 - - 1.5
402
2 - - 0.0
464
2 - - 41.5
439
One-component system
2 - - 0.0
411
2 - - 0.0
384
2 - - 0.0
398
2 - - 7.7
407
AFU_orthologue AFUA_4G00660
2 - - 0.0
376
2 - - 0.0
397
2 - - 10.8
459
2 - - 38.9
371
2 - - 0.0
435
One-component system
2 - - 0.0
401
2 - - 0.0
404
2 - - 0.0
420
2 - - 0.7
448
2 - - 10.9
455
2 - - 10.3
457
2 - - 46.7
383
2 - - 0.0
419
2 - - 0.0
406
2 - - 7.9
396
2 - - 0.0
365
2 - - 5.4
403
2 - - 0.0
421
2 - - 0.0
450
2 - - 2.0
390
2 - - 0.0
408
2 - - 0.0
559
1 - - 0.0
560
1 - - 0.0
512
1 - - 0.0
517
1 - - 0.0
540
1 - - 0.0
527
1 - - 0.0
495
1 - - 0.0
548
1 - - 0.0
486
1 - - 0.0
509
1 - - 0.0
485
1 - - 0.0
523
1 - - 0.0
488
1 - - 0.0
536
1 - - 0.0
480
1 - - 0.0
535
1 - - 0.0
508
1 - - 0.0
541
1 - - 0.0
558
1 - - 0.0
507
1 - - 0.0
506
1 - - 0.0
496
1 - - 0.0
493
1 - - 0.0
525
1 - - 0.0
534
1 - - 0.0
557
1 - - 0.0
468
1 - - 0.0
475
1 - - 0.0
515
1 - - 0.0
519
1 - - 0.0
545
1 - - 0.0
542
1 - - 0.0
498
1 - - 0.0
483
1 - - 0.0
526
1 - - 0.0
500
1 - - 0.0
533
1 - - 0.0
556
1 - - 0.0
477
1 - - 0.0
514
1 - - 0.0
513
1 - - 0.0
476
1 - - 0.0
510
1 - - 0.0
549
1 - - 0.0
469
1 - - 0.0
501
1 - - 0.0
490
1 - - 0.0
543
1 - - 0.0
539
1 - - 0.0
565
1 - - 0.0
520
1 - - 0.0
532
1 - - 0.0
492
1 - - 0.0
511
1 - - 0.0
489
1 - - 0.0
471
1 - - 0.0
465
1 - - 0.0
502
1 - - 0.0
479
1 - - 0.0
553
1 - - 0.0
555
1 - - 0.0
538
1 - - 0.0
524
1 - - 0.0
554
1 - - 0.0
552
1 - - 0.0
521
1 - - 0.0
467
1 - - 0.0
481
1 - - 0.0
474
1 - - 0.0
564
1 - - 0.0
563
1 - - 0.0
503
1 - - 0.0
484
1 - - 0.0
544
1 - - 0.0
562
1 - - 0.0
518
1 - - 0.0
497
1 - - 0.0
472
1 - - 0.0
478
1 - - 0.0
546
1 - - 0.0
537
1 - - 0.0
522
1 - - 0.0
551
1 - - 0.0
529
1 - - 0.0
504
1 - - 0.0
531
1 - - 0.0
516
1 - - 0.0
494
1 - - 0.0
487
1 - - 0.0
561
1 - - 0.0
550
1 - - 0.0
505
1 - - 0.0
547
1 - - 0.0
482
1 - - 0.0
530
1 - - 0.0
499
1 - - 0.0
470
1 - - 0.0
466
1 - - 0.0
491
1 - - 0.0
473
1 - - 0.0
528
1 - - 0.0