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CATH Superfamily 3.30.450.40

GAF domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 32: Phosphodiesterase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3',5'-cyclic-GMP phosphodiesterase. [EC: 3.1.4.35]
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
    		 19 A0A0B4LH87 A0A0B4LH87 B3LVW5 B3P3K2 B4G4E5 B4HEM4 B4JXX2 B4K9L4 B4LVU6 B4NAL6
    (9 more...)
    3',5'-cyclic-AMP phosphodiesterase. [EC: 3.1.4.53]
    Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
    • Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35).
    • It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation.
    • Formerly EC 3.1.4.n1.
    		 4 Q9VJ79 Q9VJ79 X2J6P6 X2J6P6