CATH Superfamily 3.30.450.40

Browse Functional Families

ID	Function Family (FunFam) Name	Total Sequences	Structure?	Structural Representative	PDB Sites?	Alignment Diversity (0-100)
1	Phosphodiesterase	480		-	-	79.3
3	GTP-sensing transcriptional pleiotropic repressor CodY	468	3D	2hgvA00	-	88.4
2	IclR family transcriptional regulator	464		-	-	47.9
4	Phosphodiesterase	420	3D	2k31A00	-	87.7
5	Phosphodiesterase	337	3D	2zmfB00	-	83.1
6	Phytochrome	331	3D	4o0pB01	-	86.6
8	GAF domain-containing proteins	302	3D	1vhmB00	-	86.3
7	Phosphodiesterase	288	3D	1mc0A02	-	80.7
9	DNA-binding transcriptional regulator KdgR	283	3D	1yspA00	-	91.7
10	Phosphodiesterase	240	3D	3dbaB00	-	91.2
11	Phosphodiesterase	223		-	-	75.2
12	Phosphoenolpyruvate-protein phosphotransferase PtsP	214		-	-	54.2
13	Sensor histidine kinase YehU	202		-	-	30.4
14	Phosphodiesterase	194	3D	1mc0A01	-	76.4
15	Phosphodiesterase	194	3D	3mf0B01	-	89.7
17	HTH-type transcriptional repressor AllR	186	3D	1tf1D00	-	25.9
16	Heat-inducible transcription repressor HrcA	184		-	-	59.0
18	Phosphodiesterase	175		-	-	71.2
19	Heat-inducible transcription repressor HrcA	148		-	-	58.7
20	Acetate operon transcriptional repressor IclR	147	3D	2o9aD00	-	30.4
21	Anaerobic nitric oxide reductase transcription regulator NorR	143		-	-	26.3
22	IclR family transcriptional regulator	139	3D	1ysqA00	-	48.6
23	IclR family transcriptional regulator	136		-	-	58.9
25	Stage V sporulation protein T	112	3D	2w1rA00	-	34.5
24	Formate hydrogenlyase transcriptional activator	112		-	-	20.7
26	Ethylene response sensor	108		-	-	82.0
27	Sensor histidine kinase YpdA	103		-	-	26.2
28	PAS domain S-box	96		-	-	46.6
29	PAS domain S-box	94		-	-	40.4
30	IclR family transcriptional regulator	92		-	-	42.9
32	Phosphodiesterase	90		-	-	84.4
31	Phosphodiesterase	90		-	-	72.9
33	Transcriptional regulator, IclR family	87		-	-	27.2
34	Sensor domain-containing diguanylate cyclase	85		-	-	47.9
35	PAS sensor protein	76		-	-	98.8
36	IclR family transcriptional regulator	63		-	-	0.7
37	PAS sensor protein	61		-	-	45.3
38	Two-component sensor histidine kinase KdpD	59	3D	4y2fA00	-	60.1
39	IclR family transcriptional regulator	56		-	-	77.3
40	Formate hydrogenlyase transcriptional activator	50		-	-	3.0
52	Oxygen sensor histidine kinase response regulator DevS/DosS	43	3D	2y8hB00	-	88.4
41	IclR family transcriptional regulator	42		-	-	9.7
42	Probable diguanylate cyclase YeaP	38		-	-	2.2
43	Phosphodiesterase	36		-	-	35.3
44	Putative sensor histidine kinase/response regulator	33		-	-	92.4
45	Heat-inducible transcription repressor HrcA	31		-	-	3.7
48	Free methionine-R-sulfoxide reductase	30	3D	3ko6B00	-	77.2
46	Phosphodiesterase	27		-	-	31.6
47	IclR family transcriptional regulator	26		-	-	38.3
49	Heat-inducible transcription repressor HrcA	25		-	-	8.2
51	ABC1 family protein C21C3.03	23		-	-	80.3
50	Transcriptional regulator, IclR family	23		-	-	13.0
53	IclR family transcriptional regulator	21		-	-	27.9
54	Diguanylate cyclase GGDEF	21		-	-	0.0
56	IclR family transcriptional regulator	20		-	-	15.6
55	IclR family transcriptional regulator	20		-	-	27.7
57	Two-component system sensor molecule	20		-	-	79.6
58	GAF domain-containing protein	19		-	-	0.8
77	PTS-dependent dihydroxyacetone kinase operon regulatory protein	19	3D	4lrzH01	-	2.4
60	Stage II sporulation protein E	18		-	-	12.8
59	IclR family transcriptional regulator	18		-	-	25.4
62	Adenylate/guanylate cyclase catalytic domain protein	17		-	-	2.3
61	Adenylate/guanylate cyclase catalytic domain protein	17		-	-	0.0
63	Stage II sporulation protein E	17		-	-	14.9
64	IclR family transcriptional regulator	16		-	-	7.8
65	Hydrogenase-4 transcriptional activator	15		-	-	3.9
67	Phosphodiesterase	13		-	-	75.1
68	Diguanylate cyclase GGDEF	13		-	-	4.5
66	Two-component system sensor histidine kinase KdpD	13		-	-	24.3
69	Putative transcriptional regulator	12		-	-	24.0
71	IclR family transcriptional regulator	12		-	-	19.2
74	Phosphodiesterase	12		-	-	23.1
72	PAS domain-containing protein	12		-	-	13.3
70	Unplaced genomic scaffold supercont1.28, whole genome shotgun sequence	12		-	-	18.6
73	Stage II sporulation protein E	12		-	-	0.8
78	Stage II sporulation protein E	11		-	-	2.0
80	Two component sensor histidine kinase	11		-	-	32.0
82	Sensor histidine kinase	11		-	-	88.4
76	IclR family transcriptional regulator	11		-	-	0.0
81	Vanadium nitrogenase sigma54-dependent transcriptional activator, VnfA	11		-	-	93.3
79	Heat-inducible transcription repressor HrcA	11		-	-	8.2
83	Sensor histidine kinase/response regulator, putative AFU_orthologue AFUA_4G00660	11		-	-	96.0
75	Bifunctional diguanylate cyclase/phosphodiesterase	11		-	-	0.0
89	Sigma-54-dependent Fis family transcriptional regulator	10		-	-	18.9
84	IclR family transcriptional regulator	10		-	-	40.3
85	PAS/PAC sensor protein	10		-	-	23.5
87	Phosphoserine phosphatase RsbP	10		-	-	18.4
86	Phosphatase	10		-	-	19.7
88	Heat-inducible transcription repressor HrcA	10		-	-	17.1
92	Crp family transcriptional regulator	9		-	-	0.0
90	Putative transcriptional regulator	9		-	-	16.4
94	dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A-like	9		-	-	33.1
91	IclR family transcriptional regulator	9		-	-	29.2
93	IclR family transcriptional regulator	9		-	-	2.0
96	IclR family transcriptional regulator	8		-	-	9.4
95	Transcriptional regulator, IclR family	8		-	-	19.1
97	Two-component sensor histidine kinase	8		-	-	12.2
99	Sensor histidine kinase, KdpD	7		-	-	0.0
147	Heat-inducible transcription repressor HrcA	7	3D	1stzC02	-	18.4
98	IclR family transcriptional regulator	7		-	-	10.3
100	GAF modulated transcriptional regulator, LuxR family	7		-	-	18.9
101	Sigma-54 dependent transcriptional regulator	7		-	-	0.0
112	Heat-inducible transcription repressor HrcA	6		-	-	1.9
105	Transcriptional regulator, IclR family	6		-	-	13.1
110	Histidine kinase sensor protein	6		-	-	5.2
103	Transcriptional regulatory protein	6		-	-	15.1
143	Phosphodiesterase	6	3D	3mf0A01	-	26.9
109	Stage II sporulation protein E	6		-	-	0.0
107	Sensor histidine kinase KdpD	6		-	-	5.9
111	IclR family transcriptional regulator	6		-	-	22.0
113	Histidine kinase	6		-	-	28.3
102	Phosphatase	6		-	-	17.5
108	GAF domain-containing protein	6		-	-	70.2
155	Bacteriophytochrome protein	6	3D	5i5lA01	-	15.1
106	Transcriptional regulatory protein	6		-	-	16.4
104	IclR family transcriptional regulator	6		-	-	0.0
124	Sigma-54 dependent transcriptional regulator	5		-	-	0.0
119	Two-component sensor KdpD	5		-	-	0.0
117	Diguanylate cyclase-related enzyme	5		-	-	0.0
121	Serine/threonine protein phosphatase	5		-	-	7.8
140	PelD	5	3D	4etxA01	-	1.5
115	Transcriptional regulator, IclR family	5		-	-	0.0
123	Sigma-54-dependent Fis family transcriptional regulator	5		-	-	0.0
118	Diguanylate cyclase-related enzyme	5		-	-	0.0
116	IclR family transcriptional regulator	5		-	-	1.5
120	Sensory transduction histidine kinase	5		-	-	92.7
122	Phytochrome-like protein	5		-	-	2.8
114	IclR family transcriptional regulator	5		-	-	16.6
129	Transcriptional regulator	4		-	-	3.4
131	Transcriptional regulatory protein	4		-	-	4.3
148	Heat-inducible transcription repressor HrcA	4		-	-	3.4
141	Adenylate cyclase	4		-	-	9.0
126	Serine/threonine-protein phosphatase	4		-	-	13.0
133	IclR family transcriptional regulator	4		-	-	5.0
137	Sensory transduction histidine kinase	4		-	-	43.7
135	Bacteriophytochrome	4		-	-	0.0
145	Protein serine phosphatase with GAF S S	4		-	-	5.7
130	Transcriptional regulatory protein	4		-	-	7.4
191	Bacteriophytochrome Light-regulated signal transduction histidine kinase	4	3D	4r70B01	-	1.4
142	Histidine kinase	4		-	-	5.8
128	Helix-turn-helix transcriptional regulator, IclR family	4		-	-	26.5
132	Transcriptional regulatory protein	4		-	-	8.7
209	Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containing	4	3D	3eeaB00	-	0.0
139	Histidine kinase	4		-	-	11.0
144	Phytochrome	4		-	-	6.6
125	Transcriptional regulator, IclR family	4		-	-	7.2
134	Transcriptional regulatory protein	4		-	-	7.8
127	Sigma factor sigB regulation protein rsbU	4		-	-	12.7
136	Phosphodiesterase	4		-	-	29.9
146	Stage II sporulation protein E	4		-	-	0.0
138	Phosphodiesterase	4		-	-	69.6
219	Phytochrome-like protein cph2	4	3D	4bwiB01	-	0.6
170	Phosphodiesterase	3		-	-	36.2
165	Heat-inducible transcription repressor HrcA	3		-	-	0.0
168	Histidine kinase	3		-	-	8.5
157	Histidine kinase osmosensor and regulator, putative	3		-	-	8.2
163	PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase	3		-	-	0.0
154	Heat-inducible transcription repressor HrcA	3		-	-	5.8
152	IclR family transcriptional regulator	3		-	-	12.2
160	Sensory transduction histidine kinase	3		-	-	0.0
167	Diguanylate cyclase	3		-	-	4.0
150	Hybrid sensory kinase	3		-	-	5.7
159	Two-component system sensor histidine kinase/response regulator	3		-	-	11.3
162	Diguanylate cyclase/phosphodiesterase GGDEF & EAL domains S	3		-	-	6.5
169	PAS sensor protein	3		-	-	0.0
158	Stage II sporulation E family protein	3		-	-	5.8
149	IclR family transcriptional regulator	3		-	-	1.7
156	Sensory transduction histidine kinase	3		-	-	19.5
166	GGDEF family protein	3		-	-	0.0
153	Transcriptional regulator	3		-	-	9.6
161	Sensor histidine kinase/response regulator, putative	3		-	-	0.0
164	GAF sensor signal transduction histidine kinase	3		-	-	13.3
151	IclR family transcriptional regulator	3		-	-	0.0
232	Heat-inducible transcription repressor HrcA	2		-	-	8.4
207	Stage II sporulation E family protein	2		-	-	0.0
184	Transcriptional regulator	2		-	-	3.2
181	IclR family transcriptional regulator	2		-	-	0.0
224	Two-component signal transduction	2		-	-	5.9
192	Uncharacterized protein	2		-	-	18.6
199	Stage II sporulation E family protein	2		-	-	0.0
179	IclR family transcriptional regulator	2		-	-	0.0
248	Two component signal transduction system histidine kinase with GAF sensory domain	2		-	-	40.5
234	Sensor domain-containing diguanylate cyclase	2		-	-	0.0
193	GAF domain-like protein	2		-	-	0.0
205	Stage II sporulation E family protein	2		-	-	0.0
186	Diguanylate cyclase	2		-	-	0.0
226	Serine phosphatase RsbU, regulator of sigma subunit	2		-	-	1.3
237	GGDEF family protein	2		-	-	1.4
176	Transcriptional regulator, IclR family	2		-	-	38.6
215	PleD gene product	2		-	-	0.0
180	IclR family transcriptional regulator	2		-	-	0.0
187	GAF sensor signal transduction histidine kinase	2		-	-	7.9
212	GAF domain protein	2		-	-	0.0
175	Regulator of polyketide synthase expression	2		-	-	0.0
202	Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containing	2		-	-	0.0
247	Phosphodiesterase	2		-	-	42.8
242	Phosphodiesterase	2		-	-	40.3
200	GAF domain-containing protein	2		-	-	0.0
228	Sensor histidine kinase, PAS and GAF domain-containing	2		-	-	0.0
211	Histidine kinase	2		-	-	0.0
218	Slr1385 protein	2		-	-	0.0
189	ATP-binding region ATPase domain protein	2		-	-	0.0
221	Phytochrome-like protein cph2	2		-	-	0.0
182	IclR family transcriptional regulator	2		-	-	7.7
240	Sensor histidine kinase, GAF domain-containing	2		-	-	0.0
230	Heat-inducible transcription repressor HrcA	2		-	-	0.0
239	Sensor histidine kinase, GAF domain-containing	2		-	-	0.0
206	GAF domain-containing protein	2		-	-	0.0
197	Polyketide synthase	2		-	-	0.0
245	Phosphodiesterase	2		-	-	0.0
190	ATP-binding region ATPase domain protein	2		-	-	0.0
172	Sigma factor SibG regulation protein RsbU	2		-	-	0.0
223	Pca regulon regulatory protein	2		-	-	0.0
216	Pca regulon regulatory protein	2		-	-	0.0
225	PAS sensor protein	2		-	-	0.0
222	GAF domain-containing protein	2		-	-	0.0
217	PleD gene product	2		-	-	0.0
178	IclR family transcriptional regulator	2		-	-	0.0
233	Heat-inducible transcription repressor HrcA	2		-	-	5.8
183	IclR family transcriptional regulator	2		-	-	7.0
204	GAF sensor methyl-accepting chemotaxis sensory transducer, class 40H	2		-	-	0.0
236	Sensor diguanylate cyclase, GAF domain-containing	2		-	-	0.0
177	Probable HTH-type transcriptional regulator ArcR	2		-	-	0.0
227	PAS domain-containing protein	2		-	-	0.0
249	Phosphodiesterase	2		-	-	38.2
214	Guanylate cyclase	2		-	-	0.0
196	Histidine kinase dimerisation and phosphoacceptor region	2		-	-	40.7
194	Uncharacterized protein	2		-	-	8.8
244	Phosphodiesterase	2		-	-	13.0
235	Diguanylate cyclase with GAF sensory domain	2		-	-	12.8
171	Stage II sporulation E family protein	2		-	-	0.0
185	GGDEF domain-containing protein	2		-	-	0.0
246	Sensory transduction histidine kinase	2		-	-	38.4
198	PAS sensor protein	2		-	-	39.2
229	GAF domain-containing protein	2		-	-	0.0
210	Sodium/solute symporter, GAF and PP2C family protein serine/threonine phosphatase domain protein	2		-	-	0.0
213	Uncharacterized protein	2		-	-	0.0
195	Two-component hybrid sensor and regulator	2		-	-	43.1
174	Uncharacterized protein	2		-	-	8.5
188	GAF domain-containing protein	2		-	-	0.0
243	Phosphodiesterase	2		-	-	39.2
203	Adenylyl cyclase class-3/4/guanylyl cyclase	2		-	-	0.0
238	PleD	2		-	-	0.0
173	Phosphoenolpyruvate-protein phosphotransferase	2		-	-	0.0
220	Phytochrome-like protein cph1	2		-	-	0.0
208	PAS sensor protein	2		-	-	0.0
241	Phosphodiesterase	2		-	-	37.5
201	Histidine kinase	2		-	-	11.0
231	Heat-inducible transcription repressor HrcA	2		-	-	0.0
294	PAS sensor protein	1		-	-	0.0
305	Putative signaling protein	1		-	-	0.0
281	Phosphodiesterase	1		-	-	0.0
252	Uncharacterized protein	1		-	-	0.0
279	Two-component response regulator	1		-	-	0.0
263	Uncharacterized protein	1		-	-	0.0
310	Phosphodiesterase	1		-	-	0.0
273	Sensory transduction histidine kinase	1		-	-	0.0
258	Probable transcriptional regulator	1		-	-	0.0
288	Uncharacterized protein	1		-	-	0.0
264	Chromosome 21, whole genome shotgun sequence	1		-	-	0.0
297	Sensor histidine kinase, PAS and GAF domain-containing	1		-	-	0.0
283	Phosphodiesterase	1		-	-	0.0
300	Uncharacterized protein	1		-	-	0.0
256	Transcriptional regulator IclR family	1		-	-	0.0
270	PAS sensor protein	1		-	-	0.0
261	Heat-inducible transcription repressor HrcA	1		-	-	0.0
285	Sensory transduction histidine kinase	1		-	-	0.0
257	Transcriptional regulator	1		-	-	0.0
307	Phosphodiesterase	1		-	-	0.0
299	PAS sensor protein	1		-	-	0.0
289	Phosphodiesterase	1		-	-	0.0
290	Phosphodiesterase	1		-	-	0.0
309	Phosphodiesterase	1		-	-	0.0
254	GAF domain phosphoenolpyruvate--protein phosphotransferase PtsP	1		-	-	0.0
302	Two-component hybrid sensor and regulator	1		-	-	0.0
287	Phosphodiesterase	1		-	-	0.0
274	Histidine kinase	1		-	-	0.0
250	Uncharacterized protein	1		-	-	0.0
276	Receptor-like histidine kinase BpdS	1		-	-	0.0
269	Histidine kinase dimerisation and phosphoacceptor region	1		-	-	0.0
312	Phosphodiesterase 11a,-like	1		-	-	0.0
266	Osmosensitive potassium channel sensor histidine kinase KdpD, KdpD and USP_OKCHK domain-containing	1		-	-	0.0
304	Sensory box/ggdef domain protein	1		-	-	0.0
311	Phosphodiesterase	1		-	-	0.0
272	PAS sensor protein	1		-	-	0.0
262	Chromosome 21, whole genome shotgun sequence	1		-	-	0.0
278	Diguanylate cyclase with PAS/PAC sensor	1		-	-	0.0
293	PAS sensor protein	1		-	-	0.0
267	AGAP012811-PA	1		-	-	0.0
280	Phosphodiesterase	1		-	-	0.0
253	Uncharacterized protein	1		-	-	0.0
260	Probable IclR family regulator Putative secreted protein	1		-	-	0.0
259	Transcriptional regulatory protein	1		-	-	0.0
295	Acetoin catabolism regulatory protein	1		-	-	0.0
296	Histidine kinase	1		-	-	0.0
265	Uncharacterized protein	1		-	-	0.0
282	Phosphodiesterase	1		-	-	0.0
306	Phosphodiesterase	1		-	-	0.0
308	Phosphodiesterase	1		-	-	0.0
301	PAS sensor protein	1		-	-	0.0
284	Phosphodiesterase	1		-	-	0.0
271	Histidine kinase	1		-	-	0.0
298	Glr3986 protein	1		-	-	0.0
268	Uncharacterized protein	1		-	-	0.0
255	Sensor histidine kinase, GAF domain-containing	1		-	-	0.0
303	Heat-inducible transcription repressor HrcA	1		-	-	0.0
313	Phosphodiesterase	1		-	-	0.0
286	Phosphodiesterase	1		-	-	0.0
275	Uncharacterized protein	1		-	-	0.0
251	Uncharacterized protein	1		-	-	0.0
292	Phosphodiesterase	1		-	-	0.0
291	cGMP-specific 3',5'-cyclic phosphodiesterase	1		-	-	0.0
277	Phosphodiesterase	1		-	-	0.0