CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.450.40
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.17
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt Q9Y233
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt Q9Y233
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

Q9Y233
PDE10_HUMAN
Homo sapiens
CAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

PDB Structure

PDB 2ZMF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP
Handa, N., Mizohata, E., Kishishita, S., Toyama, M., Morita, S., Uchikubo-Kamo, T., Akasaka, R., Omori, K., Kotera, J., Terada, T., Shirouzu, M., Yokoyama, S.
J.Biol.Chem.