The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
PAS domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 674: Nuclear receptor coactivator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA polymerase II regulatory region DNA binding GO:0001012
Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 D4A3Q3 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 D4A3Q3 (/IPI)
Nuclear receptor binding GO:0016922
Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.
1 D4A3Q3 (/IPI)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
1 D4A3Q3 (/IPI)
Progesterone receptor binding GO:0033142
Interacting selectively and non-covalently with a progesterone receptor.
1 D4A3Q3 (/IPI)
Retinoic acid receptor binding GO:0042974
Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.
1 D4A3Q3 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 D4A3Q3 (/IPI)
Retinoid X receptor binding GO:0046965
Interacting selectively and non-covalently with a retinoid X receptor.
1 D4A3Q3 (/IPI)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
1 D4A3Q3 (/IEP)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
1 D4A3Q3 (/IEP)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 D4A3Q3 (/IEP)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 D4A3Q3 (/IEP)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
1 D4A3Q3 (/IEP)
Hypothalamus development GO:0021854
The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.
1 D4A3Q3 (/IEP)
Cerebral cortex development GO:0021987
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
1 D4A3Q3 (/IEP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 D4A3Q3 (/IEP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 D4A3Q3 (/IMP)
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
1 D4A3Q3 (/IMP)
Response to progesterone GO:0032570
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
1 D4A3Q3 (/IMP)
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 D4A3Q3 (/IMP)
Estrous cycle GO:0044849
A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
1 D4A3Q3 (/IEP)
Positive regulation of female receptivity GO:0045925
Any process that activates or increases the receptiveness of a female to male advances.
1 D4A3Q3 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 D4A3Q3 (/IMP)
Male mating behavior GO:0060179
The specific behavior of a male organism that is associated with reproduction.
1 D4A3Q3 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 D4A3Q3 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 D4A3Q3 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 D4A3Q3 (/IDA)