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CATH Superfamily 3.30.450.20

PAS domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
PAS domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 161: Cyclic-di-AMP phosphodiesterase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cyclic-di-AMP phosphodiesterase. [EC: 3.1.4.59]
Cyclic di-3',5'-adenylate + H(2)O = 5'-O-phosphonoadenylyl-(3'->5')- adenosine.
  • The enzyme, described from Gram-positive bacteria, degrades the second messenger cyclic di-3',5'-adenylate.
  • It is a membrane-bound protein that contains a cytoplasmic facing Per-Arnt-Sim (PAS) domain, a modified GGDEF domain, and a DHH/DHHA1 domain, which confers the phosphodiesterase activity.
  • Activity requires Mn(2+) and is inhibited by pApA.
 110 A0A0E0URP0 A0A0E0URP0 A0A0E0URP0 A0A0E0URP0 A0A0E0URP0 A0A0E0URP0 A0A0E0URP0 A0A0E0URP0 A0A0E0URP0 A0A0E0URP0
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