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CATH Superfamily 3.30.1490.330

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Bifunctional glutathionylspermidine synthetase/ami...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutathionylspermidine synthase activity GO:0008885
Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate.
 67 P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA)
(57 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 65 P0AES0 (/IPI) P0AES0 (/IPI) P0AES0 (/IPI) P0AES0 (/IPI) P0AES0 (/IPI) P0AES0 (/IPI) P0AES0 (/IPI) P0AES0 (/IPI) P0AES0 (/IPI) P0AES0 (/IPI)
(55 more)
Glutathionylspermidine amidase activity GO:0008884
Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine.
 65 P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA)
(55 more)
Trypanothione-disulfide reductase activity GO:0015042
Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide.
 5 Q586P2 (/TAS) Q586P2 (/TAS) Q586P2 (/TAS) Q8IEX1 (/TAS) Q8IEX1 (/TAS)
Trypanothione synthase activity GO:0047479
Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate.
 2 Q9GT49 (/IDA) Q9GT49 (/IDA)

There are 3 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Trypanothione biosynthetic process GO:0019342
The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress.
 5 Q586P2 (/TAS) Q586P2 (/TAS) Q586P2 (/TAS) Q8IEX1 (/TAS) Q8IEX1 (/TAS)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
 5 Q586P2 (/IMP) Q586P2 (/IMP) Q586P2 (/IMP) Q8IEX1 (/IMP) Q8IEX1 (/IMP)
Trypanothione biosynthetic process GO:0019342
The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress.
 2 Q9GT49 (/IDA) Q9GT49 (/IDA)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 65 P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA) P0AES0 (/IDA)
(55 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 5 Q586P2 (/IDA) Q586P2 (/IDA) Q586P2 (/IDA) Q8IEX1 (/IDA) Q8IEX1 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 5 Q586P2 (/TAS) Q586P2 (/TAS) Q586P2 (/TAS) Q8IEX1 (/TAS) Q8IEX1 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 1 Q711P7 (/ISO)