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CATH Superfamily 3.30.1490.330

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Bifunctional glutathionylspermidine synthetase/ami...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glutathionylspermidine amidase. [EC: 3.5.1.78]
Glutathionylspermidine + H(2)O = glutathione + spermidine.
  • Transforms glutathionylspermidine into glutathione and spermidine.
  • The enzyme from Escherichia coli is bifunctional and also catalyzes the reaction of EC 6.3.1.8, resulting in a net hydrolysis of ATP.
 4225 A0A024LAS8 A0A024LAS8 A0A024LAS8 A0A024LAS8 A0A024LAS8 A0A024LAS8 A0A024LAS8 A0A024LAS8 A0A024LAS8 A0A024LAS8
(4215 more...)
Glutathionylspermidine synthase. [EC: 6.3.1.8]
Glutathione + spermidine + ATP = glutathionylspermidine + ADP + phosphate.
  • Involved in the synthesis of trypanothione in trypanosomatids.
  • The enzyme from Escherichia coli is bifunctional and also catalyzes the EC 3.5.1.78 reaction, resulting in a net hydrolysis of ATP.
 4225 A0A024LAS8 A0A024LAS8 A0A024LAS8 A0A024LAS8 A0A024LAS8 A0A024LAS8 A0A024LAS8 A0A024LAS8 A0A024LAS8 A0A024LAS8
(4215 more...)
Trypanothione synthase. [EC: 6.3.1.9]
(1) Glutathione + spermidine + ATP = glutathionylspermidine + ADP + phosphate. (2) Glutathione + glutathionylspermidine + ATP = N(1),N(8)- bis(glutathionyl)spermidine + ADP + phosphate.
  • The enzyme, characterized from several trypanosomatids (e.g. Trypanosoma cruzi) catalyzes two subsequent reactions, leading to production of trypanothione from glutathione and spermidine.
  • Some trypanosomatids (e.g. Crithidia species and some Leishmania species) also contain an enzyme that only carries out the first reaction (cf. EC 6.3.1.8).
  • The enzyme is bifunctional, and also catalyzes the hydrolysis of glutathionylspermidine and trypanothione (cf. EC 3.5.1.78).
 4 A0A2V2W671 A0A2V2W671 Q9GT49 Q9GT49