The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 32: Homocitrate synthase, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Homocitrate synthase activity GO:0004410
Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate.
15 P48570 (/IDA) P48570 (/IDA) P48570 (/IDA) P48570 (/IDA) P48570 (/IDA) P48570 (/IDA) Q4WPU2 (/IDA) Q4WPU2 (/IDA) Q4WPU2 (/IDA) Q4WPU2 (/IDA)
(5 more)
Homocitrate synthase activity GO:0004410
Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate.
7 P48570 (/IMP) P48570 (/IMP) P48570 (/IMP) P48570 (/IMP) P48570 (/IMP) P48570 (/IMP) Q9Y823 (/IMP)
Homocitrate synthase activity GO:0004410
Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate.
6 Q12122 (/ISS) Q12122 (/ISS) Q12122 (/ISS) Q12122 (/ISS) Q12122 (/ISS) Q12122 (/ISS)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lysine biosynthetic process via aminoadipic acid GO:0019878
The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway.
12 P48570 (/IGI) P48570 (/IGI) P48570 (/IGI) P48570 (/IGI) P48570 (/IGI) P48570 (/IGI) Q12122 (/IGI) Q12122 (/IGI) Q12122 (/IGI) Q12122 (/IGI)
(2 more)
Lysine biosynthetic process via aminoadipic acid GO:0019878
The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway.
11 Q12122 (/IMP) Q12122 (/IMP) Q12122 (/IMP) Q12122 (/IMP) Q12122 (/IMP) Q12122 (/IMP) Q4WPU2 (/IMP) Q4WPU2 (/IMP) Q4WPU2 (/IMP) Q4WPU2 (/IMP)
(1 more)
Histone displacement GO:0001207
The removal of histones, including histone dimers, from nucleosomes within chromatin.
6 P48570 (/IGI) P48570 (/IGI) P48570 (/IGI) P48570 (/IGI) P48570 (/IGI) P48570 (/IGI)
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
6 P48570 (/IGI) P48570 (/IGI) P48570 (/IGI) P48570 (/IGI) P48570 (/IGI) P48570 (/IGI)
Lysine biosynthetic process GO:0009085
The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid.
5 Q59TC4 (/IDA) Q59TC4 (/IDA) Q59VG1 (/IDA) Q59VG1 (/IDA) Q9Y823 (/IDA)
Lysine biosynthetic process GO:0009085
The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid.
1 Q9Y823 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
12 P48570 (/HDA) P48570 (/HDA) P48570 (/HDA) P48570 (/HDA) P48570 (/HDA) P48570 (/HDA) Q12122 (/HDA) Q12122 (/HDA) Q12122 (/HDA) Q12122 (/HDA)
(2 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
12 P48570 (/IDA) P48570 (/IDA) P48570 (/IDA) P48570 (/IDA) P48570 (/IDA) P48570 (/IDA) Q12122 (/IDA) Q12122 (/IDA) Q12122 (/IDA) Q12122 (/IDA)
(2 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 P48570 (/HDA) P48570 (/HDA) P48570 (/HDA) P48570 (/HDA) P48570 (/HDA) P48570 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9Y823 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9Y823 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9Y823 (/HDA)