The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Metal-dependent hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 30: Dipeptidase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Metallodipeptidase activity GO:0070573
Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
25 D2HVV5 (/ISS) E2R4I6 (/ISS) F6TJM7 (/ISS) F6TVV6 (/ISS) F6TVV6 (/ISS) F7E2J0 (/ISS) G1SZ68 (/ISS) G3GRR5 (/ISS) G3QTI9 (/ISS) G3TPW8 (/ISS)
(15 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
23 D2HVV5 (/ISS) E2R4I6 (/ISS) F6TJM7 (/ISS) F6TVV6 (/ISS) F6TVV6 (/ISS) F7E2J0 (/ISS) G1SZ68 (/ISS) G3GRR5 (/ISS) G3QTI9 (/ISS) G3TPW8 (/ISS)
(13 more)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
23 D2HVV5 (/ISS) E2R4I6 (/ISS) F6TJM7 (/ISS) F6TVV6 (/ISS) F6TVV6 (/ISS) F7E2J0 (/ISS) G1SZ68 (/ISS) G3GRR5 (/ISS) G3QTI9 (/ISS) G3TPW8 (/ISS)
(13 more)
Modified amino acid binding GO:0072341
Interacting selectively and non-covalently with a modified amino acid.
23 D2HVV5 (/ISS) E2R4I6 (/ISS) F6TJM7 (/ISS) F6TVV6 (/ISS) F6TVV6 (/ISS) F7E2J0 (/ISS) G1SZ68 (/ISS) G3GRR5 (/ISS) G3QTI9 (/ISS) G3TPW8 (/ISS)
(13 more)
GPI anchor binding GO:0034235
Interacting selectively and non-covalently with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes.
7 P16444 (/ISS) P16444 (/ISS) P31428 (/ISS) P31429 (/ISS) P31430 (/ISS) P43477 (/ISS) Q3SZM7 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P16444 (/IPI) P16444 (/IPI) Q9DA79 (/IPI)
Metalloexopeptidase activity GO:0008235
Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2 P16444 (/TAS) P16444 (/TAS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 P16444 (/IDA) P16444 (/IDA)
GPI anchor binding GO:0034235
Interacting selectively and non-covalently with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes.
2 P22412 (/IDA) P22412 (/IDA)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
2 P16444 (/IMP) P16444 (/IMP)
Metallodipeptidase activity GO:0070573
Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2 P16444 (/IDA) P16444 (/IDA)
Modified amino acid binding GO:0072341
Interacting selectively and non-covalently with a modified amino acid.
2 P16444 (/IDA) P16444 (/IDA)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 Q9DA79 (/IDA)
Exopeptidase activity GO:0008238
Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.
1 Q8C255 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 P31428 (/ISO)
Dipeptidase activity GO:0016805
Catalysis of the hydrolysis of a dipeptide.
1 P31430 (/TAS)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
1 P31428 (/ISO)
Metallodipeptidase activity GO:0070573
Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 P31428 (/ISO)
Modified amino acid binding GO:0072341
Interacting selectively and non-covalently with a modified amino acid.
1 P31428 (/ISO)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Antibiotic metabolic process GO:0016999
The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
23 D2HVV5 (/ISS) E2R4I6 (/ISS) F6TJM7 (/ISS) F6TVV6 (/ISS) F6TVV6 (/ISS) F7E2J0 (/ISS) G1SZ68 (/ISS) G3GRR5 (/ISS) G3QTI9 (/ISS) G3TPW8 (/ISS)
(13 more)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
23 D2HVV5 (/ISS) E2R4I6 (/ISS) F6TJM7 (/ISS) F6TVV6 (/ISS) F6TVV6 (/ISS) F7E2J0 (/ISS) G1SZ68 (/ISS) G3GRR5 (/ISS) G3QTI9 (/ISS) G3TPW8 (/ISS)
(13 more)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
23 D2HVV5 (/ISS) E2R4I6 (/ISS) F6TJM7 (/ISS) F6TVV6 (/ISS) F6TVV6 (/ISS) F7E2J0 (/ISS) G1SZ68 (/ISS) G3GRR5 (/ISS) G3QTI9 (/ISS) G3TPW8 (/ISS)
(13 more)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
23 D2HVV5 (/ISS) E2R4I6 (/ISS) F6TJM7 (/ISS) F6TVV6 (/ISS) F6TVV6 (/ISS) F7E2J0 (/ISS) G1SZ68 (/ISS) G3GRR5 (/ISS) G3QTI9 (/ISS) G3TPW8 (/ISS)
(13 more)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
23 D2HVV5 (/ISS) E2R4I6 (/ISS) F6TJM7 (/ISS) F6TVV6 (/ISS) F6TVV6 (/ISS) F7E2J0 (/ISS) G1SZ68 (/ISS) G3GRR5 (/ISS) G3QTI9 (/ISS) G3TPW8 (/ISS)
(13 more)
Homocysteine metabolic process GO:0050667
The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.
23 D2HVV5 (/ISS) E2R4I6 (/ISS) F6TJM7 (/ISS) F6TVV6 (/ISS) F6TVV6 (/ISS) F7E2J0 (/ISS) G1SZ68 (/ISS) G3GRR5 (/ISS) G3QTI9 (/ISS) G3TPW8 (/ISS)
(13 more)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
7 P16444 (/ISS) P16444 (/ISS) P31428 (/ISS) P31429 (/ISS) P31430 (/ISS) P43477 (/ISS) Q3SZM7 (/ISS)
Cellular response to nitric oxide GO:0071732
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.
7 P16444 (/ISS) P16444 (/ISS) P31428 (/ISS) P31429 (/ISS) P31430 (/ISS) P43477 (/ISS) Q3SZM7 (/ISS)
Male meiotic nuclear division GO:0007140
A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
3 Q4R7M2 (/ISS) Q5U2X4 (/ISS) Q9H4B8 (/ISS)
GPI anchor release GO:0006507
The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane.
2 P22412 (/IDA) P22412 (/IDA)
Leukotriene metabolic process GO:0006691
The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
2 P16444 (/TAS) P16444 (/TAS)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
2 P16444 (/TAS) P16444 (/TAS)
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
2 P16444 (/TAS) P16444 (/TAS)
Antibiotic metabolic process GO:0016999
The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
2 P16444 (/IDA) P16444 (/IDA)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
2 P16444 (/IMP) P16444 (/IMP)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
2 P22412 (/IDA) P22412 (/IDA)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 P16444 (/IDA) P16444 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P16444 (/IMP) P16444 (/IMP)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
2 P16444 (/IMP) P16444 (/IMP)
Homocysteine metabolic process GO:0050667
The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.
2 P16444 (/IDA) P16444 (/IDA)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
2 P22412 (/IDA) P22412 (/IDA)
Cellular response to nitric oxide GO:0071732
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.
2 P22412 (/IDA) P22412 (/IDA)
Cellular lactam catabolic process GO:0072340
The chemical reactions and pathways resulting in the breakdown of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
2 P16444 (/TAS) P16444 (/TAS)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 Q9DA79 (/IDA)
Male meiotic nuclear division GO:0007140
A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
1 Q9DA79 (/IEP)
Antibiotic metabolic process GO:0016999
The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
1 P31428 (/ISO)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 P31428 (/ISO)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P31428 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P31428 (/ISO)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
1 P31428 (/ISO)
Developmental growth GO:0048589
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
1 E7FBC7 (/IMP)
Homocysteine metabolic process GO:0050667
The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.
1 P31428 (/ISO)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
24 D2HVV5 (/ISS) E2R4I6 (/ISS) F6TJM7 (/ISS) F6TVV6 (/ISS) F6TVV6 (/ISS) F7E2J0 (/ISS) G1SZ68 (/ISS) G3GRR5 (/ISS) G3QTI9 (/ISS) G3TPW8 (/ISS)
(14 more)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
23 D2HVV5 (/ISS) E2R4I6 (/ISS) F6TJM7 (/ISS) F6TVV6 (/ISS) F6TVV6 (/ISS) F7E2J0 (/ISS) G1SZ68 (/ISS) G3GRR5 (/ISS) G3QTI9 (/ISS) G3TPW8 (/ISS)
(13 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
7 P16444 (/ISS) P16444 (/ISS) P31428 (/ISS) P31429 (/ISS) P31430 (/ISS) P43477 (/ISS) Q3SZM7 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P16444 (/IDA) P16444 (/IDA) P22412 (/IDA) P22412 (/IDA) Q9DA79 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 A0A140VJI3 (/IDA) A0A140VJI3 (/IDA) P16444 (/IDA) P16444 (/IDA)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
4 A0A140VJI3 (/IDA) A0A140VJI3 (/IDA) P16444 (/IDA) P16444 (/IDA)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
3 Q4R7M2 (/ISS) Q5U2X4 (/ISS) Q9H4B8 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P22412 (/IDA) P22412 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 P22412 (/IDA) P22412 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P16444 (/TAS) P16444 (/TAS)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
2 P16444 (/IDA) P16444 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P16444 (/HDA) P16444 (/HDA)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
1 Q9DA79 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O59832 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P31428 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 O14124 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O59832 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P31428 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9DA79 (/IDA)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
1 P31428 (/ISO)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 P31428 (/ISO)