The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

NADP-dependent oxidoreductase domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Aldo-keto reductase family 1 member C3

There are 12 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
20-alpha-hydroxysteroid dehydrogenase. [EC:]
17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha- hydroxyprogesterone + NAD(P)H.
  • Re-specific with respect to NAD(P)(+) (cf. EC
17 A0A2K5WGZ4 A0A2K5WGZ4 A0A2K5WGZ4 H9FQN9 H9FQN9 H9FQN9 P51652 Q04828 Q3U538 Q3U538
(7 more...)
Indanol dehydrogenase. [EC:]
Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H.
  • 3(20)-alpha-hydroxysteroids are also oxidized, more slowly.
14 A0A2K5WGZ4 A0A2K5WGZ4 A0A2K5WGZ4 H9FQN9 H9FQN9 H9FQN9 P42330 Q04828 Q5R7C9 Q5REQ0
(4 more...)
Delta(4)-3-oxosteroid 5-beta-reductase. [EC:]
(1) 5-beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH. (2) 17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP(+) = cortisone + NADPH.
  • The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent.
  • The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3- one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
11 A0A2R9CM81 A0A2R9CM81 A0A2R9CM81 H2QVG1 H2QVG1 H2QVG1 P31210 P51857 P51857 P51857
(1 more...)
3-alpha-hydroxysteroid 3-dehydrogenase. [EC:]
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H.
  • The enzyme acts on multiple 3-alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone.
  • The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation.
  • This entry stands for enzymes whose stereo-specificity with respect to NAD(+) or NADP(+) is not known (cf. EC and EC
6 P17516 P42330 P52895 Q5R7C9 Q95JH4 Q95JH5
Prostaglandin-F synthase. [EC:]
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH.
  • Reduces prostaglandin D(2) and prostaglandin H(2) to prostaglandin F(2); prostaglandin D(2) is not an intermediate in the reduction of prostaglandin H(2).
  • Also catalyzes the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
4 P05980 P42330 P52897 Q5R7C9
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. [EC:]
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
    4 P42330 P52895 Q04828 Q5R7C9
    Farnesol dehydrogenase. [EC:]
    (2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + NADPH.
    • Also acts, more slowly, on (2Z,6E)-farnesol, geraniol, citronerol and nerol.
    4 A0A387KC71 A0A387KC71 D3ZF77 D3ZF77
    Chlordecone reductase. [EC:]
    Chlordecone alcohol + NADP(+) = chlordecone + NADPH.
    • Chlordecone, an organochlorine pesticide, is 1,1a,3,3a,4,5,5a,5b,6- decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one.
    3 P17516 Q95JH4 Q95JH5
    Testosterone 17-beta-dehydrogenase (NADP(+)). [EC:]
    Testosterone + NADP(+) = androst-4-ene-3,17-dione + NADPH.
    • Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.
    2 P42330 Q5R7C9
    3(or 17)-alpha-hydroxysteroid dehydrogenase. [EC:]
    Androsterone + NAD(P)(+) = 5-alpha-androstane-3,17-dione + NAD(P)H.
    • Acts on the 3-alpha-hydroxy group of androgens of the 5-alpha- androstane series; and also, more slowly, on the 17-alpha-hydroxyl group of both androgenic and estrogenic substrates (cf. EC
    2 Q6AYQ2 Q91WR5
    3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)). [EC:]
    Testosterone + NAD(+) = androstenedione + NADH.
    • Also acts on other 17-beta-hydroxysteroids, on the 3-alpha-hydroxy group of pregnanes and bile acids.
    • Different from EC or EC
    • Formerly EC
    2 P42330 Q5R7C9
    3-alpha-hydroxysteroid 3-dehydrogenase (Si-specific). [EC:]
    A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H.
    • The enzyme acts on androsterone and other 3-alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin.
    • Si-specific with respect to NAD(+) or NADP(+) (cf. EC
    1 P23457