The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
483
3D
1zsxA00 - 76.5
3
425
3D
6f78B00 - 91.4
9
337
3D
6f8oA00 - 90.3
2
283
3D
1mzrB00 - 97.8
4
250
3D
1pz1B00 - 98.5
7
NAD
P
234
3D
5zcmA00 - 96.8
5
H
221
3D
1lqaB00 - 84.1
6
211
3D
4gacB00 - 95.6
8
196
3D
1ur3M00 - 91.3
15
108
3D
1vp5B00 - 97.0
10
106
3D
3h7uA00 - 81.8
11
98 - - 94.1
13
97
3D
2vdgA00 - 91.2
17
93
3D
2bp1D00 - 59.7
12
92 - - 79.8
14
NAD
P
84 - - 91.1
16
76 - - 29.3
20
68
3D
4aubG00 - 17.5
18
57 - - 85.0
19
49 - - 67.7
21
49 - - 10.8
22
45 - - 6.4
23
45 - - 90.6
24
38 - - 71.2
26
37 - - 72.5
25
+
37 - - 56.7
31
37
3D
4ijrC00 - 84.0
27
37 - - 43.0
29
36
3D
1qwkA00 - 92.5
28
36 - - 6.0
30
33 - - 63.0
32
32 - - 17.3
33
29 - - 19.0
68
26
3D
5y7nA00 - 54.7
34
26 - - 90.1
35
24 - - 17.5
36
20 - - 81.6
37
L-GalDH
20 - - 71.6
63
19
3D
4exbF00 - 2.1
38
19 - - 33.0
39
18 - - 81.2
40
17 - - 3.1
41
16 - - 73.9
43
16 - - 49.1
44
16 - - 82.6
42
16 - - 34.1
45
AKR
14 - - 84.9
46
aldose reductase
13 - - 75.1
47
13 - - 8.0
48
12 - - 55.3
49
12 - - 88.1
51
AKR8
11 - - 73.6
52
11 - - 84.1
53
11 - - 86.6
50
11 - - 49.8
55
10 - - 22.2
56
10 - - 82.2
54
10 - - 19.5
58
9 - - 70.0
57
9 - - 59.2
60
8 - - 0.0
59
8 - - 1.7
61
7 - - 83.4
64
7 - - 80.5
62
7 - - 0.8
65
6 - - 11.3
66
6 - - 2.3
67
6 - - 19.8
71
5 - - 9.3
74
5 - - 2.9
80
5
3D
3h7rA00 - 12.5
69
5 - - 42.2
75
5 - - 15.8
76
5 - - 10.2
72
5 - - 0.4
73
5 - - 0.0
70
5 - - 75.4
78
4 - - 72.3
82
4 - - 9.1
81
4 - - 6.0
84
GCY1
4 - - 71.6
77
4 - - 11.4
79
4 - - 62.3
83
4 - - 3.8
85
3 - - 18.2
89
aldose reductase
3 - - 10.6
91
3 - - 2.3
92
3 - - 3.8
94
3 - - 13.3
90
3 - - 7.3
86
3 - - 27.1
87
3 - - 48.2
93
3 - - 6.7
88
3 - - 76.2
127
GCY1
2 - - 0.0
101
2 - - 6.3
96
2 - - 31.2
116
2 - - 2.5
112
2 - - 9.3
108
2 - - 7.4
128
+ Eurofung
2 - - 0.0
132
2 - - 35.0
117
2 - - 1.0
105
2 - - 0.0
111
2 - - 0.0
129
+ Eurofung
2 - - 0.0
124
2 - - 7.9
113
2 - - 7.5
120
2 - - 0.7
109
2 - - 0.4
99
2 - - 7.6
131
+ Eurofung
2 - - 0.0
95
2 - - 23.5
106
2 - - 3.3
121
2 - - 0.0
98
2 - - 41.0
119
2 - - 0.0
107
2 - - 4.5
110
2 - - 1.0
130
+ Eurofung
2 - - 0.0
102
2 - - 1.8
115
2 - - 1.7
122
2 - - 0.0
125
2 - - 45.9
118
2 - - 2.4
100
2 - - 7.5
126
2 - - 1.3
114
2 - - 0.0
104
Aldo-keto reductase family protein
2 - - 0.0
103
2 - - 8.7
97
2 - - 35.1
133
2 - - 39.0
123
2 - - 11.1
153
1 - - 0.0
180
1 - - 0.0
136
1 - - 0.0
137
1 - - 0.0
191
1 - - 0.0
187
1 - - 0.0
212
1 - - 0.0
170
1 - - 0.0
142
1 - - 0.0
207
1 - - 0.0
155
1 - - 0.0
175
1 - - 0.0
198
1 - - 0.0
202
1 - - 0.0
184
1 - - 0.0
181
1 - - 0.0
154
1 - - 0.0
217
1 - - 0.0
158
1 - - 0.0
165
1 - - 0.0
147
1 - - 0.0
209
1 - - 0.0
149
1 - - 0.0
210
1 - - 0.0
139
1 - - 0.0
168
1 - - 0.0
135
1 - - 0.0
145
1 - - 0.0
178
1 - - 0.0
152
1 - - 0.0
213
1 - - 0.0
200
1 - - 0.0
161
1 - - 0.0
192
1 - - 0.0
199
1 - - 0.0
195
1 - - 0.0
174
1 - - 0.0
188
1 - - 0.0
183
1 - - 0.0
148
1 - - 0.0
157
1 - - 0.0
203
1 - - 0.0
204
1 - - 0.0
179
1 - - 0.0
141
1 - - 0.0
146
1 - - 0.0
164
1 - - 0.0
211
1 - - 0.0
218
1 - - 0.0
160
1 - - 0.0
193
+
1 - - 0.0
189
1 - - 0.0
144
1 - - 0.0
177
1 - - 0.0
205
1 - - 0.0
151
1 - - 0.0
138
1 - - 0.0
182
1 - - 0.0
167
1 - - 0.0
163
1 - - 0.0
140
1 - - 0.0
214
1 - - 0.0
186
1 - - 0.0
173
1 - - 0.0
156
1 - - 0.0
219
1 - - 0.0
196
1 - - 0.0
206
1 - - 0.0
194
1 - - 0.0
220
1 - - 0.0
171
1 - - 0.0
197
1 - - 0.0
176
1 - - 0.0
215
1 - - 0.0
150
1 - - 0.0
208
1 - - 0.0
159
1 - - 0.0
162
1 - - 0.0
201
1 - - 0.0
143
1 - - 0.0
169
1 - - 0.0
190
1 - - 0.0
172
1 - - 0.0
216
1 - - 0.0
166
1 - - 0.0
134
1 - - 0.0
185
1 - - 0.0