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CATH Superfamily 3.20.20.100

NADP-dependent oxidoreductase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 210: Bifunctional protein STORR

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
1,2-dehydroreticuline synthase. [EC: 1.14.19.54]
(S)-reticuline + [reduced NADPH--hemoprotein reductase] + O(2) = 1,2- dehydroreticuline + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O.
  • The enzyme from Papaver rhoeas (field poppy) is specific for (S)- reticuline and does not act on the (R)-form.
  • The enzyme from Papaver somniferum (opium poppy), which is involved in the biosynthesis of morphine and related alkaloids, forms a fusion protein with EC 1.5.1.27, which catalyzes the reduction of 1,2- dehydroreticuline to (R)-reticuline, thus forming an epimerase system that converts (S)-reticuline to (R)-reticuline.
 1 P0DKI7
1,2-dehydroreticulinium reductase (NADPH). [EC: 1.5.1.27]
(R)-reticuline + NADP(+) = 1,2-dehydroreticulinium + NADPH.
  • Reduces the 1,2-dehydroreticulinium ion to (R)-reticuline, which is a direct precursor of morphinan alkaloids in the poppy plant.
  • The enzyme does not catalyze the reverse reaction to any significant extent under physiological conditions.
 1 P0DKI7