The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: E3 ubiquitin-protein ligase Midline-1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
17 O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI)
(7 more)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
17 O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP)
(7 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
17 O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA)
(7 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
17 O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA)
(7 more)
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
17 O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI)
(7 more)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
15 O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI)
(5 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
15 O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI) O15344 (/IPI)
(5 more)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
3 O70583 (/ISO) P82457 (/ISO) Q9QUS6 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 O70583 (/ISO) P82457 (/ISO) Q9QUS6 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 O70583 (/ISO) P82457 (/ISO) Q9QUS6 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
3 O70583 (/ISO) P82457 (/ISO) Q9QUS6 (/ISO)
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
3 O70583 (/ISO) P82457 (/ISO) Q9QUS6 (/ISO)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
2 O70583 (/ISO) P82457 (/ISO)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein localization to microtubule GO:0035372
A process in which a protein is transported to, or maintained at, a microtubule.
17 O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP)
(7 more)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
15 O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS)
(5 more)
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
15 O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS)
(5 more)
Positive regulation of stress-activated MAPK cascade GO:0032874
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
15 O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP) O15344 (/IMP)
(5 more)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
15 O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS)
(5 more)
Protein localization to microtubule GO:0035372
A process in which a protein is transported to, or maintained at, a microtubule.
3 O70583 (/ISO) P82457 (/ISO) Q9QUS6 (/ISO)
Negative regulation of microtubule depolymerization GO:0007026
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
2 O70583 (/IGI) P82457 (/IGI)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
2 Q9UJV3 (/IMP) Q9UJV3 (/IMP)
Positive regulation of stress-activated MAPK cascade GO:0032874
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
2 O70583 (/ISO) P82457 (/ISO)
Negative regulation of viral transcription GO:0032897
Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription.
2 Q9UJV3 (/IDA) Q9UJV3 (/IDA)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
2 Q9UJV3 (/IDA) Q9UJV3 (/IDA)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
2 Q9UJV3 (/IDA) Q9UJV3 (/IDA)
Negative regulation of viral entry into host cell GO:0046597
Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell.
2 Q9UJV3 (/IDA) Q9UJV3 (/IDA)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 Q9UJV3 (/IMP) Q9UJV3 (/IMP)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
2 Q9UJV3 (/IMP) Q9UJV3 (/IMP)
Negative regulation of viral release from host cell GO:1902187
Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell.
2 Q9UJV3 (/IDA) Q9UJV3 (/IDA)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q9QUS6 (/ISO)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q9QUS6 (/ISS)
Negative regulation of viral transcription GO:0032897
Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription.
1 Q9QUS6 (/ISO)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
1 Q9QUS6 (/ISO)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 Q9QUS6 (/ISO)
Negative regulation of viral entry into host cell GO:0046597
Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell.
1 Q9QUS6 (/ISO)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q9QUS6 (/ISO)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 Q9QUS6 (/ISO)
Negative regulation of viral release from host cell GO:1902187
Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell.
1 Q9QUS6 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
17 O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA) O15344 (/IDA)
(7 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
15 O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS)
(5 more)
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
15 O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS) O15344 (/TAS)
(5 more)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
3 O70583 (/ISO) P82457 (/ISO) Q9QUS6 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O70583 (/IDA) P82457 (/IDA)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
2 O70583 (/IDA) P82457 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q9UJV3 (/HDA) Q9UJV3 (/HDA)