The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 55: Crumbs cell polarity complex component 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P82279 (/IPI) Q8VHS2 (/IPI)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Establishment or maintenance of epithelial cell apical/basal polarity GO:0045197
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
7 A0A2R8QCM5 (/IGI) B3DGM6 (/IGI) B3DJP2 (/IGI) Q1A5L2 (/IGI) Q1A5L3 (/IGI) Q1L8E9 (/IGI) Q1L927 (/IGI)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
2 B3DGM6 (/IPI) Q1A5L2 (/IPI)
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157
The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
2 B3DGM6 (/IPI) Q1A5L2 (/IPI)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 B3DGM6 (/IMP) Q1A5L2 (/IMP)
Ventricular system development GO:0021591
The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus.
2 B3DGM6 (/IMP) Q1A5L2 (/IMP)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
2 B3DGM6 (/IMP) Q1A5L2 (/IMP)
Apical protein localization GO:0045176
Any process in which a protein is transported to, or maintained in, apical regions of the cell.
2 B3DGM6 (/IGI) Q1A5L2 (/IGI)
Establishment or maintenance of epithelial cell apical/basal polarity GO:0045197
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
2 B3DGM6 (/IMP) Q1A5L2 (/IMP)
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
2 B3DGM6 (/IEP) Q1A5L2 (/IEP)
Embryonic retina morphogenesis in camera-type eye GO:0060059
The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage.
2 B3DGM6 (/IMP) Q1A5L2 (/IMP)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
2 B3DGM6 (/IDA) Q1A5L2 (/IDA)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
2 B3DGM6 (/IMP) Q1A5L2 (/IMP)
Plasma membrane organization GO:0007009
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
1 Q8VHS2 (/IMP)
Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
1 P82279 (/TAS)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
1 P82279 (/TAS)
Eye photoreceptor cell development GO:0042462
Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.
1 Q8VHS2 (/IMP)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
1 Q8VHS2 (/IMP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
7 A0A2R8QCM5 (/IPI) B3DGM6 (/IPI) B3DJP2 (/IPI) Q1A5L2 (/IPI) Q1A5L3 (/IPI) Q1L8E9 (/IPI) Q1L927 (/IPI)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 B3DGM6 (/IDA) Q1A5L2 (/IDA) Q8VHS2 (/IDA)
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
2 D3ZZL8 (/IDA) Q8VHS2 (/IDA)
Photoreceptor inner segment GO:0001917
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
1 D3ZZL8 (/IDA)
Photoreceptor inner segment GO:0001917
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
1 Q8VHS2 (/ISO)
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
1 Q8VHS2 (/ISO)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
1 P82279 (/IDA)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
1 Q8VHS2 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P82279 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q8VHS2 (/ISO)