The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
931
3D
3r05B01 - 49.7
3
796
3D
3mw2B00 - 84.3
2
756
3D
3fbyC02 - 92.3
4
727
3D
3r05B05 - 81.8
5
724
3D
3r05B02 - 80.6
6
650
3D
2v5yA01 - 90.8
7
547
3D
3r05B04 - 57.1
8
461 - - 92.8
9
442
3D
1ux6A02 - 70.3
21
435
3D
4lbqD00 - 98.4
10
423 - - 79.5
11
413 - - 92.6
12
376 - - 96.2
13
362 - - 81.3
14
356 - - 72.5
227
315
3D
5f5qB00 - 44.5
23
313
3D
3wv6B02 - 96.8
15
309 - - 92.4
17
304
3D
2e6vE01 - 86.8
16
300 - - 87.9
18
284
3D
5hcfF01 - 95.6
70
280
3D
4ayuE00 - 95.3
19
272 - - 77.9
20
255 - - 74.0
22
223 - - 72.9
24
215 - - 76.2
28
213
3D
4ygeE00 - 87.6
25
206
3D
2vh9B00 - 91.9
27
198
3D
1q56A01 - 95.9
26
186 - - 87.7
29
181 - - 77.2
31
180
3D
3pveB00 - 91.6
30
180 - - 82.6
32
165 - - 83.9
33
162 - - 56.2
34
161 - - 84.7
35
160 - - 73.3
54
159
3D
5vwgA00 - 84.4
37
156
3D
4gwnA02 - 96.4
36
156 - - 73.8
41
150
3D
2oujA00 - 85.0
38
148 - - 90.4
39
147 - - 96.6
40
145 - - 91.6
42
141 - - 77.4
43
139
3D
5l73B00 - 77.4
44
135 - - 69.7
46
134
3D
3b9cD00 - 89.2
78
133
3D
3wv6B01 - 86.9
45
129 - - 82.4
184
129
3D
5tpcA01 - 90.3
48
126 - - 98.2
47
126 - - 61.9
49
XI
125 - - 53.1
51
123 - - 93.7
50
123 - - 83.6
52
123
3D
2wjsA02 - 57.4
65
122
3D
5ik8B01 - 73.3
75
119
3D
5lk5J01 - 78.0
53
118 - - 77.7
63
118
3D
5ik8B02 - 58.7
55
117 - - 96.3
73
116
3D
4hanB02 - 73.6
57
115
3D
2wjsA01 - 66.5
56
115 - - 75.4
58
113 - - 65.7
61
113
3D
2wjsA03 - 70.8
59
113 - - 96.1
60
112 - - 53.0
237
111
3D
4m3cH00 - 87.7
62
110 - - 68.3
64
110 - - 77.3
66
109 - - 71.4
67
108 - - 76.7
68
XXI
108 - - 89.8
124
106
3D
5duxD00 - 94.3
69
105 - - 46.1
71
104 - - 87.6
72
103 - - 85.7
74
100 - - 46.6
76
99 - - 76.9
77
98 - - 94.6
79
96 - - 80.9
80
95 - - 30.5
82
93 - - 82.9
81
93 - - 96.9
83
92 - - 73.4
84
90 - - 83.2
85
XXVII
90 - - 95.8
89
90
3D
5vxzB01 - 76.3
114
4
90
3D
3wdyD00 - 89.6
86
88 - - 95.5
87
86 - - 75.7
88
84 - - 84.2
90
82 - - 71.0
91
82 - - 83.3
92
81 - - 78.0
107
80
3D
1lhwA00 - 84.7
94
80 - - 91.7
93
80 - - 82.3
95
79 - - 77.7
96
78 - - 93.9
98
78
3D
5mc9A01 - 72.4
97
77 - - 82.9
99
76 - - 82.6
101
75
3D
3sh5A00 - 72.4
100
74 - - 32.4
102
73 - - 70.9
103
73 - - 96.0
105
73
3D
2uurA00 - 85.7
104
72 - - 72.5
118
71
3D
5vxzB02 - 76.7
106
71 - - 68.1
108
XXII
70 - - 69.7
109
69 - - 76.5
110
68 - - 78.4
111
68 - - 92.4
112
66 - - 91.1
119
65
3D
2jd4B01 - 71.0
113
65 - - 88.4
116
65
3D
5mc9A02 - 72.8
115
65 - - 59.1
117
64 - - 6.5
120
63 - - 18.3
122
63 - - 83.3
121
63 - - 6.8
145
62
3D
4hl0B01 - 85.6
123
62 - - 90.2
388
61
3D
3wg4B00 - 88.6
125
61 - - 82.0
127
60
3D
2jd4B02 - 79.3
126
58 - - 91.7
131
58
3D
2d44A01 - 68.2
128
56 - - 96.1
129
55 - - 88.6
130
55 - - 96.1
155
55
3D
4hl0B02 - 69.3
132
54 - - 94.3
135
53 - - 83.3
133
53 - - 51.4
134
53 - - 94.9
136
52 - - 88.4
137
50 - - 15.9
139
48 - - 90.1
138
48 - - 20.4
140
48 - - 90.8
141
48 - - 87.1
144
47 - - 77.9
142
47 - - 42.9
143
47 - - 84.7
147
45 - - 74.4
146
45 - - 21.3
148
44 - - 73.0
149
43 - - 82.6
150
42 - - 95.4
151
41 - - 83.0
176
41
3D
6a66A00 - 56.9
153
40 - - 38.0
152
40 - - 90.9
154
39 - - 38.6
157
39 - - 82.5
156
39 - - 64.5
159
38 - - 89.3
158
38 - - 44.2
160
37 - - 87.8
161
37 - - 82.9
163
37 - - 70.5
162
37 - - 85.7
164
37 - - 86.4
165
36 - - 71.2
166
36 - - 37.0
168
35 - - 22.0
171
35 - - 84.1
170
35 - - 45.0
167
35 - - 69.7
169
35 - - 28.2
172
34 - - 89.5
173
34 - - 81.8
175
33 - - 57.9
174
33 - - 34.3
178
31 - - 87.0
180
31 - - 89.1
177
31 - - 49.4
181
31 - - 72.9
195
31
3D
4itcA00 - 30.1
179
31 - - 89.8
182
30 - - 94.2
183
30 - - 85.9
185
29 - - 45.6
187
28 - - 53.5
188
28 - - 82.4
186
28 - - 18.6
193
27 - - 79.6
189
27 - - 16.7
191
27 - - 40.9
192
27 - - 55.7
190
27 - - 79.0
194
26 - - 80.6
197
26 - - 13.7
198
26 - - 88.6
196
26 - - 41.1
200
25 - - 77.7
199
25 - - 72.2
202
25 - - 93.8
201
25 - - 77.6
203
25 - - 33.5
206
24 - - 33.5
205
24 - - 34.3
207
24 - - 72.2
208
24 - - 15.7
204
24 - - 76.5
211
23 - - 42.9
213
23 - - 94.9
212
23 - - 11.0
214
23 - - 81.6
209
23 - - 86.1
210
23 - - 88.3
215
22 - - 93.0
217
22 - - 79.6
216
22 - - 15.3
220
21 - - 46.8
218
21 - - 76.1
221
21 - - 9.6
222
21 - - 87.6
219
21 - - 76.9
226
20 - - 9.2
224
20 - - 87.8
225
20 - - 29.4
228
20 - - 36.9
223
20 - - 51.4
234
19 - - 83.4
232
19 - - 49.9
233
19 - - 4.0
230
19 - - 39.0
229
19 - - 29.1
231
19 - - 37.0
236
18 - - 71.0
235
18 - - 90.7
244
17
3D
3vv1B00 - 85.7
301
17
3D
2a71D00 - 9.8
238
17 - - 84.5
241
16 - - 38.5
240
16 - - 37.0
239
16 - - 78.3
242
16 - - 11.3
303
15
3D
2dwrA01 - 52.8
245
15 - - 71.9
243
15 - - 17.9
285
14
3D
4zxkB00 - 5.7
246
14 - - 93.4
249
14 - - 68.5
247
14 - - 9.2
268
14
3D
4xogA01 - 3.7
248
14 - - 39.6
260
13 - - 83.7
309
13
3D
6ekuA03 - 0.0
254
13 - - 35.0
262
13 - - 77.3
251
13 - - 69.0
256
13 - - 86.3
255
13 - - 9.2
250
13 - - 61.2
257
13 - - 56.7
259
13 - - 78.2
362
13
3D
5jozB02 - 80.1
261
13 - - 79.2
253
Cadherin plus 7TM domain
13 - - 24.6
258
13 - - 13.6
252
13 - - 75.3
265
Cadherin plus 7TM domain
12 - - 19.7
264
12 - - 49.6
263
12 - - 73.3
267
12 - - 8.8
316
12
3D
4ateA00 - 76.4
270
12 - - 97.1
266
12 - - 29.1
269
12 - - 8.7
298
12
3D
2w68C00 - 5.3
271
12 - - 87.8
272
11 - - 15.8
275
11 - - 43.7
279
11 - - 22.0
274
11 - - 41.7
278
11 - - 27.6
276
11 - - 72.4
280
11 - - 73.9
273
11 - - 32.7
281
11 - - 11.9
277
11 - - 7.7
311
10
3D
4wzfB00 - 19.3
288
10 - - 92.2
286
10 - - 14.6
287
10 - - 75.7
284
10 - - 8.0
289
10 - - 1.6
282
10 - - 29.3
290
10 - - 1.1
283
10 - - 7.6
295
9 - - 8.2
300
9 - - 21.9
296
9 - - 20.6
294
9 - - 5.9
293
9 - - 14.7
292
9 - - 11.9
291
9 - - 12.7
299
9 - - 9.8
302
9 - - 81.5
297
9 - - 38.0
312
8 - - 34.4
308
8 - - 5.9
310
8 - - 68.7
314
8 - - 85.9
307
8 - - 73.4
305
8 - - 14.9
313
8 - - 71.7
304
8 - - 96.7
306
8 - - 20.0
325
7 - - 8.8
324
7 - - 12.5
329
7 - - 83.8
323
7 - - 23.1
330
7 - - 40.1
322
7 - - 16.7
490
7
3D
1fv3B01 - 1.8
327
7 - - 9.4
320
IX
7 - - 1.1
326
7 - - 10.2
315
7 - - 45.8
328
7 - - 36.3
317
7 - - 26.4
321
7 - - 7.4
319
7 - - 8.8
318
7 - - 37.2
331
6 - - 63.9
337
6 - - 8.9
333
6 - - 6.9
332
6 - - 19.9
335
6 - - 5.1
334
6 - - 21.4
338
6 - - 73.6
339
6 - - 90.7
336
6 - - 62.8
358
5 - - 32.6
350
5 - - 18.7
340
5 - - 87.2
348
5 - - 0.0
351
5 - - 20.5
342
5 - - 10.3
341
5 - - 6.3
349
5 - - 2.6
346
5 - - 8.8
352
5 - - 18.1
359
5 - - 38.9
360
5 - - 26.0
353
5 - - 0.5
354
5 - - 6.4
347
5 - - 0.0
361
5 - - 80.4
355
5 - - 40.2
363
5 - - 75.3
343
5 - - 16.3
345
5 - - 12.4
344
5 - - 13.8
357
5 - - 44.4
356
5 - - 3.2
378
4 - - 8.4
382
4 - - 11.2
389
4 - - 11.0
364
4 - - 3.7
367
4 - - 33.1
391
4 - - 8.5
379
4 - - 0.0
370
4 - - 12.6
380
4 - - 2.0
381
4 - - 3.3
392
4 - - 3.2
373
4 - - 9.6
399
4 - - 71.6
386
4 - - 36.3
366
4 - - 36.8
400
4 - - 10.4
369
4 - - 24.9
372
4 - - 33.6
394
4 - - 9.8
393
4 - - 25.0
375
4 - - 0.7
387
4 - - 33.5
368
4 - - 24.3
395
4 - - 7.6
374
N-acetyl-beta-glucosaminyl
4 - - 10.0
385
4 - - 8.9
377
4 - - 11.1
402
4 - - 17.0
398
4 - - 35.1
384
4 - - 2.0
376
4 - - 8.3
397
4 - - 4.6
371
4 - - 22.6
401
4 - - 43.5
383
4 - - 6.2
396
4 - - 7.5
365
4 - - 31.2
390
4 - - 4.3
443
3 - - 11.9
437
3 - - 1.2
431
3 - - 0.0
418
3 - - 15.9
410
3 - - 36.7
430
3 - - 61.8
415
3 - - 2.9
438
3 - - 0.0
444
3 - - 63.2
417
3 - - 0.0
405
3 - - 37.8
416
3 - - 0.0
436
3 - - 14.2
445
3 - - 75.6
441
3 - - 11.6
413
3 - - 0.0
432
3 - - 7.1
427
3 - - 0.0
446
3 - - 79.3
426
3 - - 7.6
428
3 - - 31.6
414
3 - - 0.0
425
3 - - 0.7
424
3 - - 10.0
434
3 - - 6.9
442
3 - - 5.4
429
3 - - 38.8
409
3 - - 10.9
412
3 - - 1.5
433
3 - - 7.2
440
3 - - 17.3
423
3 - - 0.0
422
3 - - 0.0
439
3 - - 0.0
411
3 - - 0.0
407
3 - - 12.4
435
3 - - 3.3
404
3 - - 38.6
420
3 - - 0.0
419
3 - - 0.6
406
Synaptic protein
3 - - 20.2
403
3 - - 29.0
421
3 - - 11.0
408
3 - - 13.0
559
2 - - 37.7
560
2 - - 34.5
512
2 - - 26.7
463
2 - - 8.2
458
2 - - 16.3
517
2 - - 0.0
451
2 - - 40.1
454
2 - - 20.8
572
2 - - 40.0
540
2 - - 4.0
527
2 - - 0.0
571
2 - - 44.9
495
2 - - 8.4
548
2 - - 0.0
486
2 - - 1.1
509
2 - - 0.0
569
2 - - 38.4
485
2 - - 0.5
523
2 - - 1.1
460
2 - - 30.9
453
2 - - 11.2
488
2 - - 0.6
447
2 - - 39.2
536
2 - - 3.0
452
2 - - 42.5
480
2 - - 8.2
535
2 - - 2.2
508
2 - - 0.7
541
2 - - 1.8
558
2 - - 34.6
507
2 - - 2.3
567
2 - - 34.6
506
2 - - 1.2
496
2 - - 1.9
456
Synaptic protein
2 - - 18.8
568
2 - - 31.1
493
2 - - 8.3
525
2 - - 6.8
534
2 - - 11.2
557
2 - - 34.6
468
2 - - 6.3
700
2
3D
1ikqA01 - 0.0
475
2 - - 0.0
515
2 - - 32.0
519
2 - - 0.0
545
2 - - 1.5
542
2 - - 0.0
498
2 - - 0.0
483
2 - - 0.0
566
2 - - 36.2
526
2 - - 0.0
500
2 - - 1.3
533
2 - - 8.9
556
2 - - 37.0
462
2 - - 0.0
477
2 - - 10.0
514
2 - - 34.7
513
2 - - 11.2
476
2 - - 0.8
510
2 - - 0.7
449
2 - - 39.7
549
2 - - 0.0
469
2 - - 0.0
501
2 - - 0.0
543
2 - - 0.0
461
2 - - 0.0
539
2 - - 4.2
565
2 - - 15.3
520
2 - - 0.0
532
2 - - 0.0
492
2 - - 0.0
511
2 - - 6.0
489
2 - - 7.6
471
2 - - 0.0
465
2 - - 0.0
502
2 - - 1.3
479
2 - - 9.3
553
2 - - 15.2
555
2 - - 35.3
538
2 - - 9.6
524
2 - - 4.6
554
2 - - 14.6
552
2 - - 0.0
521
2 - - 0.0
467
2 - - 1.3
481
2 - - 1.6
474
2 - - 0.0
564
2 - - 26.4
563
CELSR1
2 - - 30.0
503
2 - - 0.0
484
2 - - 6.6
544
2 - - 1.1
464
2 - - 0.7
562
2 - - 6.3
497
2 - - 12.4
518
2 - - 0.0
472
2 - - 0.0
478
2 - - 0.0
546
2 - - 7.0
537
2 - - 3.9
522
2 - - 2.5
551
2 - - 33.3
529
2 - - 0.0
504
2 - - 0.7
459
2 - - 10.9
531
2 - - 5.2
516
2 - - 41.2
494
2 - - 7.0
487
2 - - 2.1
561
2 - - 31.7
448
2 - - 39.4
455
2 - - 11.0
457
2 - - 26.0
550
2 - - 34.9
505
2 - - 1.2
547
2 - - 8.5
482
2 - - 10.7
499
2 - - 0.0
530
2 - - 0.0
470
2 - - 0.0
570
2 - - 54.5
466
2 - - 2.2
450
2 - - 48.2
491
2 - - 0.0
473
2 - - 8.6
528
2 - - 6.3
737
1 - - 0.0
580
1 - - 0.0
767
1 - - 0.0
798
1 - - 0.0
805
1 - - 0.0
722
1 - - 0.0
634
1 - - 0.0
578
1 - - 0.0
695
1 - - 0.0
728
1 - - 0.0
742
1 - - 0.0
675
1 - - 0.0
684
1 - - 0.0
739
1 - - 0.0
662
1 - - 0.0
758
1 - - 0.0
783
1 - - 0.0
706
1 - - 0.0
789
1 - - 0.0
772
1 - - 0.0
627
1 - - 0.0
594
1 - - 0.0
715
1 - - 0.0
653
1 - - 0.0
716
1 - - 0.0
686
1 - - 0.0
685
1 - - 0.0
743
1 - - 0.0
778
1 - - 0.0
720
1 - - 0.0
586
1 - - 0.0
723
1 - - 0.0
637
1 - - 0.0
595
1 - - 0.0
690
1 - - 0.0
752
1 - - 0.0
579
1 - - 0.0
683
1 - - 0.0
765
1 - - 0.0
784
1 - - 0.0
573
1 - - 0.0
762
1 - - 0.0
638
1 - - 0.0
734
1 - - 0.0
661
1 - - 0.0
800
1 - - 0.0
581
1 - - 0.0
678
1 - - 0.0
605
1 - - 0.0
607
1 - - 0.0
773
1 - - 0.0
813
Cnx
1 - - 0.0
644
1 - - 0.0
759
1 - - 0.0
694
1 - - 0.0
816
1 - - 0.0
652
1 - - 0.0
791
1 - - 0.0
796
1 - - 0.0
787
1 - - 0.0
582
1 - - 0.0
775
1 - - 0.0
746
1 - - 0.0
744
1 - - 0.0
633
1 - - 0.0
718
1 - - 0.0
672
1 - - 0.0
764
1 - - 0.0
769
1 - - 0.0
803
1 - - 0.0
751
1 - - 0.0
606
1 - - 0.0
724
1 - - 0.0
691
1 - - 0.0
666
1 - - 0.0
677
1 - - 0.0
708
1 - - 0.0
650
CELSR1
1 - - 0.0
710
1 - - 0.0
590
1 - - 0.0
664
1 - - 0.0
588
1 - - 0.0
646
1 - - 0.0
756
1 - - 0.0
617
1 - - 0.0
651
1 - - 0.0
629
1 - - 0.0
810
1 - - 0.0
574
1 - - 0.0
660
1 - - 0.0
806
1 - - 0.0
790
1 - - 0.0
604
1 - - 0.0
717
1 - - 0.0
815
1 - - 0.0
671
1 - - 0.0
632
1 - - 0.0
610
1 - - 0.0
692
1 - - 0.0
663
1 - - 0.0
725
1 - - 0.0
615
1 - - 0.0
797
1 - - 0.0
766
1 - - 0.0
658
1 - - 0.0
659
1 - - 0.0
645
1 - - 0.0
682
1 - - 0.0
635
1 - - 0.0
575
1 - - 0.0
788
1 - - 0.0
709
1 - - 0.0
589
1 - - 0.0
614
1 - - 0.0
699
1 - - 0.0
687
1 - - 0.0
818
1 - - 0.0
626
1 - - 0.0
583
1 - - 0.0
757
1 - - 0.0
782
1 - - 0.0
809
1 - - 0.0
591
1 - - 0.0
745
1 - - 0.0
736
1 - - 0.0
603
1 - - 0.0
781
1 - - 0.0
620
1 - - 0.0
730
1 - - 0.0
611
1 - - 0.0
584
1 - - 0.0
665
1 - - 0.0
649
1 - - 0.0
689
1 - - 0.0
648
1 - - 0.0
642
1 - - 0.0
812
1 - - 0.0
795
1 - - 0.0
585
1 - - 0.0
794
1 - - 0.0
727
1 - - 0.0
674
1 - - 0.0
732
1 - - 0.0
811
1 - - 0.0
622
1 - - 0.0
819
1 - - 0.0
776
1 - - 0.0
801
1 - - 0.0
754
1 - - 0.0
747
1 - - 0.0
704
1 - - 0.0
681
1 - - 0.0
619
1 - - 0.0
698
1 - - 0.0
621
1 - - 0.0
680
1 - - 0.0
679
1 - - 0.0
598
1 - - 0.0
780
1 - - 0.0
647
1 - - 0.0
786
1 - - 0.0
740
1 - - 0.0
602
1 - - 0.0
719
1 - - 0.0
612
1 - - 0.0
701
1 - - 0.0
820
1 - - 0.0
817
1 - - 0.0
731
1 - - 0.0
668
1 - - 0.0
688
1 - - 0.0
750
1 - - 0.0
657
1 - - 0.0
774
1 - - 0.0
768
1 - - 0.0
693
1 - - 0.0
673
1 - - 0.0
593
1 - - 0.0
770
1 - - 0.0
641
1 - - 0.0
576
1 - - 0.0
761
1 - - 0.0
616
1 - - 0.0
640
1 - - 0.0
738
1 - - 0.0
804
1 - - 0.0
623
1 - - 0.0
755
1 - - 0.0
777
1 - - 0.0
628
1 - - 0.0
733
1 - - 0.0
630
1 - - 0.0
748
1 - - 0.0
608
1 - - 0.0
711
1 - - 0.0
705
1 - - 0.0
785
1 - - 0.0
599
1 - - 0.0
609
1 - - 0.0
587
1 - - 0.0
667
1 - - 0.0
741
1 - - 0.0
714
1 - - 0.0
601
1 - - 0.0
779
1 - - 0.0
753
1 - - 0.0
697
1 - - 0.0
726
1 - - 0.0
707
1 - - 0.0
624
1 - - 0.0
792
1 - - 0.0
656
1 - - 0.0
729
1 - - 0.0
771
1 - - 0.0
814
1 - - 0.0
808
1 - - 0.0
760
1 - - 0.0
749
1 - - 0.0
596
1 - - 0.0
735
1 - - 0.0
613
1 - - 0.0
721
1 - - 0.0
669
1 - - 0.0
702
1 - - 0.0
639
1 - - 0.0
636
1 - - 0.0
577
1 - - 0.0
643
1 - - 0.0
600
1 - - 0.0
821
Putative secreted protein
1 - - 0.0
696
1 - - 0.0
713
1 - - 0.0
676
1 - - 0.0
670
1 - - 0.0
625
1 - - 0.0
592
1 - - 0.0
631
1 - - 0.0
712
1 - - 0.0
763
1 - - 0.0
793
1 - - 0.0
654
1 - - 0.0
618
1 - - 0.0
655
1 - - 0.0
703
1 - - 0.0
799
1 - - 0.0
597
1 - - 0.0
802
1 - - 0.0
807
1 - - 0.0