The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 42: Neuropilin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 B3DFP6 (/IPI) F1QN93 (/IPI) O35375 (/IPI) O60462 (/IPI) Q69DB6 (/IPI) Q6T490 (/IPI) Q6T868 (/IPI)
Vascular endothelial growth factor-activated receptor activity GO:0005021
Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 O60462 (/NAS)
Vascular endothelial growth factor-activated receptor activity GO:0005021
Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 O60462 (/TAS)
Semaphorin receptor activity GO:0017154
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 O35375 (/IDA)
Semaphorin receptor activity GO:0017154
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 E1BEL6 (/ISS)
Semaphorin receptor activity GO:0017154
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 O60462 (/NAS)
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
1 O60462 (/TAS)
Cytokine binding GO:0019955
Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
1 O60462 (/NAS)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 O60462 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O35375 (/ISO)

There are 51 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
10 A0A0B5JS61 (/IMP) B0S6D0 (/IMP) B3DFP6 (/IMP) F1QN93 (/IMP) Q69DB5 (/IMP) Q69DB6 (/IMP) Q6T490 (/IMP) Q6T491 (/IMP) Q6T867 (/IMP) Q6T868 (/IMP)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
10 A0A0B5JS61 (/IGI) B0S6D0 (/IGI) B3DFP6 (/IGI) F1QN93 (/IGI) Q69DB5 (/IGI) Q69DB6 (/IGI) Q6T490 (/IGI) Q6T491 (/IGI) Q6T867 (/IGI) Q6T868 (/IGI)
Regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947
Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
10 A0A0B5JS61 (/IMP) B0S6D0 (/IMP) B3DFP6 (/IMP) F1QN93 (/IMP) Q69DB5 (/IMP) Q69DB6 (/IMP) Q6T490 (/IMP) Q6T491 (/IMP) Q6T867 (/IMP) Q6T868 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
6 A0A0B5JS61 (/IMP) B0S6D0 (/IMP) O35375 (/IMP) Q69DB5 (/IMP) Q6T491 (/IMP) Q6T867 (/IMP)
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
5 A0A0B5JS61 (/IMP) B0S6D0 (/IMP) Q69DB5 (/IMP) Q6T491 (/IMP) Q6T867 (/IMP)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
5 B3DFP6 (/IDA) F1QN93 (/IDA) Q69DB6 (/IDA) Q6T490 (/IDA) Q6T868 (/IDA)
Facial nerve structural organization GO:0021612
The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
2 O35375 (/IMP) Q8K2T3 (/IMP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 O60462 (/NAS)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
1 O35375 (/IMP)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
1 E1BEL6 (/ISS)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 O35375 (/IMP)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 O60462 (/TAS)
Outflow tract septum morphogenesis GO:0003148
The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.
1 O35375 (/IGI)
Outflow tract septum morphogenesis GO:0003148
The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.
1 O60462 (/ISS)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 O60462 (/NAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 O35276 (/IEP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 O60462 (/NAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 O60462 (/TAS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 O35375 (/IGI)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 E1BEL6 (/ISS)
Positive regulation of endothelial cell migration GO:0010595
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 O60462 (/TAS)
Trigeminal nerve structural organization GO:0021637
The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
1 Q8K2T3 (/IMP)
Vestibulocochlear nerve structural organization GO:0021649
The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.
1 O35375 (/IMP)
Nerve development GO:0021675
The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.
1 O35375 (/IMP)
Nerve development GO:0021675
The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.
1 O60462 (/ISS)
Branchiomotor neuron axon guidance GO:0021785
The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.
1 Q8K2T3 (/IMP)
Gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021828
The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus.
1 O35375 (/IMP)
Ventral trunk neural crest cell migration GO:0036486
The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta.
1 O35375 (/IMP)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O60462 (/TAS)
Axon extension involved in axon guidance GO:0048846
The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues.
1 O35375 (/IMP)
Axon extension involved in axon guidance GO:0048846
The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues.
1 O60462 (/ISS)
Negative chemotaxis GO:0050919
The directed movement of a motile cell or organism towards a lower concentration of a chemical.
1 O35375 (/IGI)
Negative chemotaxis GO:0050919
The directed movement of a motile cell or organism towards a lower concentration of a chemical.
1 O35375 (/IMP)
Negative chemotaxis GO:0050919
The directed movement of a motile cell or organism towards a lower concentration of a chemical.
1 E1BEL6 (/ISS)
Sympathetic ganglion development GO:0061549
The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.
1 O35375 (/IMP)
Sympathetic ganglion development GO:0061549
The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.
1 O60462 (/ISS)
Trigeminal ganglion development GO:0061551
The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.
1 O35375 (/IMP)
Sensory neuron axon guidance GO:0097374
The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses.
1 O35375 (/IMP)
Sympathetic neuron projection extension GO:0097490
Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 O35375 (/IMP)
Sympathetic neuron projection extension GO:0097490
Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 O60462 (/ISS)
Sympathetic neuron projection guidance GO:0097491
The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
1 O35375 (/IMP)
Sympathetic neuron projection guidance GO:0097491
The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
1 O60462 (/ISS)
Regulation of postsynapse organization GO:0099175
Any process that modulates the physical form of a postsynapse.
1 O35375 (/IDA)
Regulation of postsynapse organization GO:0099175
Any process that modulates the physical form of a postsynapse.
1 O35375 (/IMP)
Neural crest cell migration involved in autonomic nervous system development GO:1901166
Any neural crest cell migration that is involved in autonomic nervous system development.
1 O35375 (/IMP)
Semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285
Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance.
1 O35375 (/IMP)
Semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285
Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance.
1 O60462 (/ISS)
Semaphorin-plexin signaling pathway involved in axon guidance GO:1902287
Any semaphorin-plexin signaling pathway that is involved in axon guidance.
1 Q8K2T3 (/IMP)
Facioacoustic ganglion development GO:1903375
The process whose specific outcome is the progression of an acoustico-facial VII-VIII ganglion complex over time, from its formation to the mature structure.
1 O35375 (/IMP)
Dorsal root ganglion morphogenesis GO:1904835
The developmental process by which a dorsal root ganglion is generated and organized.
1 O35375 (/IMP)
Cellular response to leukemia inhibitory factor GO:1990830
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
1 O35375 (/IEP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O35375 (/TAS) O60462 (/TAS)
Semaphorin receptor complex GO:0002116
A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.
1 O60462 (/NAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O35375 (/IC)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O60462 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O60462 (/NAS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 O35375 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 O35375 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 O35375 (/IMP)
Integral component of postsynaptic membrane GO:0099055
The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O35375 (/IDA)