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CATH Superfamily 2.40.30.10

Translation factors

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Translation factors
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Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 293: 3-dehydro-bile acid delta(4,6)-reductase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-dehydro-bile acid Delta(4,6)-reductase. [EC: 1.3.1.114]
(1) 3-oxocholan-24-oyl-CoA + NAD(+) = 3-oxochol-4-en-24-oyl-CoA + NADH. (2) 3-oxochol-4-en-24-oyl-CoA + NAD(+) = 3-oxochol-4,6-dien-24-oyl-CoA + NADH. (3) 12-alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) = 12-alpha-hydroxy- 3-oxochol-4-en-24-oyl-CoA + NADH. (4) 12-alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) = 12-alpha- hydroxy-3-oxochol-4,6-dien-24-oyl-CoA + NADH.
  • The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7-alpha-dehydroxylation pathway.
  • The enzyme catalyzes two subsequent reductions of the double bonds within the bile acid A/B rings, following 7-alpha-dehydration.
 9 A0A494WPK7 A0A494WPK7 A0A494WPK7 B0NAQ4 B0NAQ4 B0NAQ4 F7KQH2 F7KQH2 F7KQH2