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CATH Superfamily 2.30.34.10

Leishmanolysin domain 4

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Leishmanolysin domain 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: GP63, leishmanolysin

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Leishmanolysin. [EC: 3.4.24.36]
Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.
  • A membrane-bound glycoprotein found on the promastigote of various species of Leishmania protozoans.
  • Contains consensus sequence for a zinc binding site; Z-Tyr-Leu-NHOH is a strong inhibitor.
  • The enzyme can activate its proenzyme by cleavage of the 100- Val-|-Val-101 bond.
  • An acidic pH optimum is found with certain protein substrates.
  • Belongs to peptidase family M8.
 1 P08148