The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"SH3 Domains
".
FunFam 7: nebulin isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 15 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
|
14 |
B7ZCI2 (/ISS)
D4A164 (/ISS)
E2RQ93 (/ISS)
F1MF57 (/ISS)
F1RVG6 (/ISS)
F6YZ84 (/ISS)
F7BZ05 (/ISS)
F7CGV7 (/ISS)
G1LHM9 (/ISS)
G1PJG9 (/ISS)
(4 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
13 |
A2AQA9 (/IPI)
A2AQB2 (/IPI)
E9Q1W3 (/IPI)
F6X9B6 (/IPI)
O76041 (/IPI)
P20929 (/IPI)
Q14847 (/IPI)
Q14847 (/IPI)
Q14847 (/IPI)
Q14847 (/IPI)
(3 more) |
|
Ion transmembrane transporter activity GO:0015075
Enables the transfer of an ion from one side of a membrane to the other.
|
6 | Q14847 (/ISS) Q14847 (/ISS) Q14847 (/ISS) Q14847 (/ISS) Q61792 (/ISS) Q61792 (/ISS) |
|
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
|
4 | Q14847 (/TAS) Q14847 (/TAS) Q14847 (/TAS) Q14847 (/TAS) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
4 | Q14847 (/HDA) Q14847 (/HDA) Q14847 (/HDA) Q14847 (/HDA) |
|
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
3 | O76041 (/IDA) Q61792 (/IDA) Q61792 (/IDA) |
|
Ion transmembrane transporter activity GO:0015075
Enables the transfer of an ion from one side of a membrane to the other.
|
2 | Q61792 (/ISO) Q61792 (/ISO) |
|
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | Q8I7C3 (/IDA) |
|
Tropomyosin binding GO:0005523
Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.
|
1 | O76041 (/IPI) |
|
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
|
1 | O76041 (/IDA) |
|
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
|
1 | O76041 (/IPI) |
|
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
|
1 | O76041 (/NAS) |
|
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
|
1 | P20929 (/TAS) |
|
Ion transmembrane transporter activity GO:0015075
Enables the transfer of an ion from one side of a membrane to the other.
|
1 | Q99MZ8 (/IDA) |
|
Filamin binding GO:0031005
Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
|
1 | O76041 (/IPI) |
There are 19 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cardiac muscle thin filament assembly GO:0071691
The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle.
|
14 |
B7ZCI2 (/ISS)
D4A164 (/ISS)
E2RQ93 (/ISS)
F1MF57 (/ISS)
F1RVG6 (/ISS)
F6YZ84 (/ISS)
F7BZ05 (/ISS)
F7CGV7 (/ISS)
G1LHM9 (/ISS)
G1PJG9 (/ISS)
(4 more) |
|
Muscle fiber development GO:0048747
The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
|
7 | A0A2R8QKU1 (/IMP) B0UY61 (/IMP) F1Q6R4 (/IMP) F1Q824 (/IMP) Q1MSX9 (/IMP) Q1MSY0 (/IMP) Q5BLE1 (/IMP) |
|
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
6 | Q14847 (/ISS) Q14847 (/ISS) Q14847 (/ISS) Q14847 (/ISS) Q61792 (/ISS) Q61792 (/ISS) |
|
Regulation of actin filament length GO:0030832
Any process that controls the length of actin filaments in a cell.
|
4 | A2AQA9 (/TAS) A2AQB2 (/TAS) E9Q1W3 (/TAS) F6X9B6 (/TAS) |
|
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
4 | A2AQA9 (/TAS) A2AQB2 (/TAS) E9Q1W3 (/TAS) F6X9B6 (/TAS) |
|
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q61792 (/ISO) Q61792 (/ISO) |
|
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q99MZ8 (/IDA) |
|
Pole cell formation GO:0007279
Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells.
|
1 | Q8I7C3 (/IMP) |
|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
1 | Q8I7C3 (/IMP) |
|
Sperm individualization GO:0007291
The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane.
|
1 | Q8I7C3 (/IMP) |
|
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
1 | P20929 (/TAS) |
|
Somatic muscle development GO:0007525
The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.
|
1 | P20929 (/NAS) |
|
Regulation of myofibril size GO:0014881
Any process that modulates the size of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
|
1 | Q8I7C3 (/IMP) |
|
Muscle filament sliding GO:0030049
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
|
1 | P20929 (/TAS) |
|
Regulation of actin filament length GO:0030832
Any process that controls the length of actin filaments in a cell.
|
1 | P20929 (/NAS) |
|
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
1 | Q8I7C3 (/IMP) |
|
Positive regulation of pole plasm oskar mRNA localization GO:0045856
Any process that activates or increases the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.
|
1 | Q8I7C3 (/IMP) |
|
Muscle thin filament assembly GO:0071689
The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in striated muscle.
|
1 | Q8I7C3 (/IMP) |
|
Cardiac muscle thin filament assembly GO:0071691
The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle.
|
1 | O76041 (/IMP) |
There are 31 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
14 |
B7ZCI2 (/ISS)
D4A164 (/ISS)
E2RQ93 (/ISS)
F1MF57 (/ISS)
F1RVG6 (/ISS)
F6YZ84 (/ISS)
F7BZ05 (/ISS)
F7CGV7 (/ISS)
G1LHM9 (/ISS)
G1PJG9 (/ISS)
(4 more) |
|
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
14 |
B7ZCI2 (/ISS)
D4A164 (/ISS)
E2RQ93 (/ISS)
F1MF57 (/ISS)
F1RVG6 (/ISS)
F6YZ84 (/ISS)
F7BZ05 (/ISS)
F7CGV7 (/ISS)
G1LHM9 (/ISS)
G1PJG9 (/ISS)
(4 more) |
|
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
7 | A2AQA9 (/IDA) A2AQB2 (/IDA) E9Q1W3 (/IDA) F6X9B6 (/IDA) O76041 (/IDA) P20929 (/IDA) Q8I7C3 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | Q14847 (/IDA) Q14847 (/IDA) Q14847 (/IDA) Q14847 (/IDA) Q61792 (/IDA) Q61792 (/IDA) |
|
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
|
6 | Q14847 (/ISS) Q14847 (/ISS) Q14847 (/ISS) Q14847 (/ISS) Q61792 (/ISS) Q61792 (/ISS) |
|
Striated muscle thin filament GO:0005865
Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.
|
4 | A2AQA9 (/TAS) A2AQB2 (/TAS) E9Q1W3 (/TAS) F6X9B6 (/TAS) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
4 | Q14847 (/HDA) Q14847 (/HDA) Q14847 (/HDA) Q14847 (/HDA) |
|
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
|
4 | A2AQA9 (/ISO) A2AQB2 (/ISO) E9Q1W3 (/ISO) F6X9B6 (/ISO) |
|
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
4 | A2AQA9 (/ISO) A2AQB2 (/ISO) E9Q1W3 (/ISO) F6X9B6 (/ISO) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
4 | A2AQA9 (/ISO) A2AQB2 (/ISO) E9Q1W3 (/ISO) F6X9B6 (/ISO) |
|
Contractile fiber GO:0043292
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
|
4 | A2AQA9 (/IDA) A2AQB2 (/IDA) E9Q1W3 (/IDA) F6X9B6 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
3 | Q61792 (/IDA) Q61792 (/IDA) Q8I7C3 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q61792 (/ISO) Q61792 (/ISO) |
|
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
|
2 | A0A096MK15 (/IDA) F1M1J2 (/IDA) |
|
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
2 | G1TDU6 (/IDA) Q9DEH4 (/IDA) |
|
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
|
2 | Q61792 (/ISO) Q61792 (/ISO) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | O76041 (/HDA) P20929 (/HDA) |
|
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
1 | O76041 (/IDA) |
|
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
1 | F1MF57 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8I7C3 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P20929 (/TAS) |
|
Striated muscle thin filament GO:0005865
Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.
|
1 | Q9Y5Z1 (/NAS) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
1 | P20929 (/TAS) |
|
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
1 | P34416 (/HDA) |
|
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
|
1 | Q99MZ8 (/IDA) |
|
A band GO:0031672
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
|
1 | Q8I7C3 (/IDA) |
|
I band GO:0031674
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
|
1 | O76041 (/NAS) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q6P516 (/IDA) |
|
Striated muscle dense body GO:0055120
A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.
|
1 | P34416 (/HDA) |
|
Sperm individualization complex GO:0070864
A macromolecular complex that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst.
|
1 | Q8I7C3 (/IDA) |
|
Skeletal muscle myofibril GO:0098723
A myofibril of a skeletal muscle fiber.
|
1 | G1TDU6 (/IDA) |