The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"SH3 Domains
".
FunFam 169: Mitogen-activated protein kinase kinase kinase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
3 | Q5TCX8 (/ISS) Q95UN8 (/ISS) Q95UN8 (/ISS) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
2 | Q95UN8 (/IDA) Q95UN8 (/IDA) |
|
JUN kinase kinase kinase activity GO:0004706
Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
|
2 | Q95UN8 (/IDA) Q95UN8 (/IDA) |
|
JUN kinase kinase kinase activity GO:0004706
Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
|
2 | Q95UN8 (/ISS) Q95UN8 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q5TCX8 (/IPI) |
There are 20 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
3 | Q5TCX8 (/ISS) Q95UN8 (/ISS) Q95UN8 (/ISS) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
2 | Q95UN8 (/IDA) Q95UN8 (/IDA) |
|
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
|
2 | Q95UN8 (/IGI) Q95UN8 (/IGI) |
|
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
|
2 | Q95UN8 (/IMP) Q95UN8 (/IMP) |
|
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
|
2 | Q95UN8 (/IMP) Q95UN8 (/IMP) |
|
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
|
2 | Q95UN8 (/TAS) Q95UN8 (/TAS) |
|
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
|
2 | Q95UN8 (/IMP) Q95UN8 (/IMP) |
|
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
|
2 | Q95UN8 (/TAS) Q95UN8 (/TAS) |
|
Dorsal closure, elongation of leading edge cells GO:0007394
The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis.
|
2 | Q95UN8 (/IMP) Q95UN8 (/IMP) |
|
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
2 | Q95UN8 (/IMP) Q95UN8 (/IMP) |
|
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
2 | Q95UN8 (/IMP) Q95UN8 (/IMP) |
|
Imaginal disc fusion, thorax closure GO:0046529
The joining of the parts of the wing imaginal discs, giving rise to the adult thorax.
|
2 | Q95UN8 (/IGI) Q95UN8 (/IGI) |
|
Imaginal disc fusion, thorax closure GO:0046529
The joining of the parts of the wing imaginal discs, giving rise to the adult thorax.
|
2 | Q95UN8 (/IMP) Q95UN8 (/IMP) |
|
Dorsal appendage formation GO:0046843
Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration.
|
2 | Q95UN8 (/IMP) Q95UN8 (/IMP) |
|
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q95UN8 (/IGI) Q95UN8 (/IGI) |
|
Imaginal disc-derived male genitalia morphogenesis GO:0048803
The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc.
|
2 | Q95UN8 (/IMP) Q95UN8 (/IMP) |
|
Imaginal disc-derived female genitalia morphogenesis GO:0048804
The process in which the anatomical structures of female genitalia are generated and organized from the genital disc.
|
2 | Q95UN8 (/IMP) Q95UN8 (/IMP) |
|
Cellular response to ethanol GO:0071361
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
|
2 | Q95UN8 (/IMP) Q95UN8 (/IMP) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | Q5TCX8 (/ISS) |
|
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
|
1 | Q5TCX8 (/ISS) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
2 | Q95UN8 (/IDA) Q95UN8 (/IDA) |