The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: Voltage-dependent L-type calcium channel subunit b...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 22 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
21 D4A055 (/IPI) O00305 (/IPI) O00305 (/IPI) O00305 (/IPI) O00305 (/IPI) O00305 (/IPI) O00305 (/IPI) O00305 (/IPI) O00305 (/IPI) O00305 (/IPI)
(11 more)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
5 A2SZ58 (/IDA) B0F0C6 (/IDA) B0F0D1 (/IDA) Q08289 (/IDA) T2B3N4 (/IDA)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
4 Q8CC27 (/ISO) Q8CC27 (/ISO) Q8R0S4 (/ISO) Q8R0S4 (/ISO)
High voltage-gated calcium channel activity GO:0008331
Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.
4 Q8CC27 (/TAS) Q8CC27 (/TAS) Q8R0S4 (/TAS) Q8R0S4 (/TAS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
4 Q8CC27 (/ISO) Q8CC27 (/ISO) Q8R0S4 (/ISO) Q8R0S4 (/ISO)
Voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels GO:0099635
Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission
4 Q8CC27 (/IMP) Q8CC27 (/IMP) Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
3 D4A055 (/IMP) Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
3 Q8CC27 (/IDA) Q8CC27 (/IDA) Q8VGC3 (/IDA)
Calcium channel regulator activity GO:0005246
Modulates the activity of a calcium channel.
2 Q8CC27 (/ISO) Q8CC27 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 D4A055 (/IDA) Q8VGC3 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
2 Q8CC27 (/ISO) Q8CC27 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q8CC27 (/ISO) Q8CC27 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
2 Q8CC27 (/ISO) Q8CC27 (/ISO)
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
2 Q8CC27 (/ISO) Q8CC27 (/ISO)
Voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels GO:0099635
Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission
2 Q8R0S4 (/IDA) Q8R0S4 (/IDA)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 Q8VGC3 (/TAS)
Calcium channel regulator activity GO:0005246
Modulates the activity of a calcium channel.
1 Q8VGC3 (/IDA)
Calcium channel activity GO:0005262
Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 Q08289 (/NAS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q8VGC3 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q8VGC3 (/IPI)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q08289 (/ISS)
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
1 Q8VGC3 (/IPI)

There are 61 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cardiac conduction GO:0061337
Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.
14 O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS)
(4 more)
Membrane depolarization GO:0051899
The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.
13 O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS)
(3 more)
Regulation of voltage-gated calcium channel activity GO:1901385
Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity.
13 O00305 (/IMP) O00305 (/IMP) O00305 (/IMP) O00305 (/IMP) O00305 (/IMP) O00305 (/IMP) O00305 (/IMP) O00305 (/IMP) O00305 (/IMP) O00305 (/IMP)
(3 more)
Embryonic heart tube morphogenesis GO:0003143
The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
9 A0A0R4IFE8 (/IMP) A0A0R4IK22 (/IMP) A0A0R4IWG7 (/IMP) A0A0R4IXU9 (/IMP) A2SZ54 (/IMP) B2XY72 (/IMP) B2XY73 (/IMP) B2XY76 (/IMP) B2XY77 (/IMP)
Epiboly involved in gastrulation with mouth forming second GO:0055113
The expansion of one cell sheet over other cells involved in deuterostomic gastrulation.
8 A2SZ57 (/IMP) A2SZ58 (/IMP) A8WHZ4 (/IMP) A8WHZ5 (/IMP) B0F0C6 (/IMP) B0F0D0 (/IMP) B0F0D1 (/IMP) T2B3N4 (/IMP)
Regulation of voltage-gated calcium channel activity GO:1901385
Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity.
4 Q8CC27 (/ISO) Q8CC27 (/ISO) Q8R0S4 (/ISO) Q8R0S4 (/ISO)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 D4A055 (/IMP) Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
3 Q08289 (/ISS) Q8CC27 (/ISS) Q8CC27 (/ISS)
Membrane depolarization during AV node cell action potential GO:0086045
The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
3 Q8CC27 (/ISS) Q8CC27 (/ISS) Q8VGC3 (/ISS)
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
3 Q8CC27 (/ISS) Q8CC27 (/ISS) Q8VGC3 (/ISS)
Membrane depolarization during atrial cardiac muscle cell action potential GO:0098912
The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
3 Q8CC27 (/ISS) Q8CC27 (/ISS) Q8VGC3 (/ISS)
Positive regulation of high voltage-gated calcium channel activity GO:1901843
Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity.
3 Q08289 (/ISS) Q8CC27 (/ISS) Q8CC27 (/ISS)
Positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1904879
Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel.
3 Q08289 (/ISS) Q8CC27 (/ISS) Q8CC27 (/ISS)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q8R0S4 (/ISO) Q8R0S4 (/ISO)
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2 Q8CC27 (/IMP) Q8CC27 (/IMP)
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
2 Q8CC27 (/IMP) Q8CC27 (/IMP)
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 Q8R0S4 (/ISO) Q8R0S4 (/ISO)
Gamma-aminobutyric acid secretion GO:0014051
The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Neuronal action potential propagation GO:0019227
The propagation of an action potential along an axon, away from the soma.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Synaptic transmission, glutamatergic GO:0035249
The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
CAMP metabolic process GO:0046058
The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Spleen development GO:0048536
The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Thymus development GO:0048538
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Peyer's patch development GO:0048541
The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Muscle fiber development GO:0048747
The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Nervous system process GO:0050877
A organ system process carried out by any of the organs or tissues of neurological system.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Detection of light stimulus involved in visual perception GO:0050908
The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q8CC27 (/ISO) Q8CC27 (/ISO)
Calcium ion import GO:0070509
The directed movement of calcium ions into a cell or organelle.
2 Q8CC27 (/ISO) Q8CC27 (/ISO)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
2 Q8CC27 (/ISO) Q8CC27 (/ISO)
Membrane depolarization during AV node cell action potential GO:0086045
The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
2 Q8CC27 (/ISO) Q8CC27 (/ISO)
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
2 Q8CC27 (/ISO) Q8CC27 (/ISO)
Membrane depolarization during atrial cardiac muscle cell action potential GO:0098912
The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
2 Q8CC27 (/ISO) Q8CC27 (/ISO)
Positive regulation of voltage-gated calcium channel activity GO:1901387
Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity.
2 Q8R0S4 (/ISO) Q8R0S4 (/ISO)
Positive regulation of high voltage-gated calcium channel activity GO:1901843
Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity.
2 Q8CC27 (/ISO) Q8CC27 (/ISO)
Positive regulation of protein localization to nucleolus GO:1904751
Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus.
2 Q8R0S4 (/ISO) Q8R0S4 (/ISO)
Positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1904879
Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel.
2 Q8CC27 (/ISO) Q8CC27 (/ISO)
Cellular response to leukemia inhibitory factor GO:1990830
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
2 Q8R0S4 (/IEP) Q8R0S4 (/IEP)
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
2 Q8R0S4 (/ISO) Q8R0S4 (/ISO)
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
2 Q8R0S4 (/IDA) Q8R0S4 (/IDA)
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q8VGC3 (/TAS)
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
1 Q08289 (/TAS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 D4A055 (/IDA)
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q08289 (/IDA)
Calcium ion import GO:0070509
The directed movement of calcium ions into a cell or organelle.
1 Q08289 (/IDA)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
1 Q8VGC3 (/IDA)
Membrane depolarization during AV node cell action potential GO:0086045
The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
1 Q08289 (/IMP)
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
1 Q08289 (/IMP)
Membrane depolarization during atrial cardiac muscle cell action potential GO:0098912
The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
1 Q08289 (/IMP)
Regulation of voltage-gated calcium channel activity GO:1901385
Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity.
1 Q8VGC3 (/IDA)
Positive regulation of voltage-gated calcium channel activity GO:1901387
Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity.
1 D4A055 (/IDA)
Positive regulation of high voltage-gated calcium channel activity GO:1901843
Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity.
1 Q8VGC3 (/IDA)
Positive regulation of protein localization to nucleolus GO:1904751
Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus.
1 D4A055 (/IDA)
Positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1904879
Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel.
1 Q8VGC3 (/IDA)
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
1 D4A055 (/IDA)

There are 24 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
19 O00305 (/IDA) O00305 (/IDA) O00305 (/IDA) O00305 (/IDA) O00305 (/IDA) O00305 (/IDA) O00305 (/IDA) O00305 (/IDA) O00305 (/IDA) O00305 (/IDA)
(9 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
18 O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS)
(8 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS)
(3 more)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
13 O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS) O00305 (/TAS)
(3 more)
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
4 Q8CC27 (/ISO) Q8CC27 (/ISO) Q8R0S4 (/ISO) Q8R0S4 (/ISO)
L-type voltage-gated calcium channel complex GO:1990454
A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.
4 P54288 (/ISS) Q8CC27 (/ISS) Q8CC27 (/ISS) Q9MZL5 (/ISS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q8R0S4 (/ISO) Q8R0S4 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8R0S4 (/ISO) Q8R0S4 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8R0S4 (/ISO) Q8R0S4 (/ISO)
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
2 Q8R0S4 (/ISO) Q8R0S4 (/ISO)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
2 Q8R0S4 (/ISO) Q8R0S4 (/ISO)
Photoreceptor ribbon synapse GO:0098684
A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon.
2 Q8CC27 (/IMP) Q8CC27 (/IMP)
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
2 Q8R0S4 (/ISO) Q8R0S4 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 Q8R0S4 (/IDA) Q8R0S4 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 Q8R0S4 (/IMP) Q8R0S4 (/IMP)
L-type voltage-gated calcium channel complex GO:1990454
A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.
2 Q08289 (/IDA) Q8VGC3 (/IDA)
L-type voltage-gated calcium channel complex GO:1990454
A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.
2 Q8CC27 (/ISO) Q8CC27 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 D4A055 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 D4A055 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q08289 (/NAS)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 D4A055 (/IDA)
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
1 D4A055 (/IDA)
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
1 D4A055 (/IMP)