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CATH Superfamily 2.30.29.30

Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 84: G protein-coupled receptor kinase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
[Beta-adrenergic-receptor] kinase. [EC: 2.7.11.15]
ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.
  • Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly.
  • Does not act on casein or histones.
  • Inhibited by Zn(2+) and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14 and EC 2.7.11.16).
  • Formerly EC 2.7.1.126.
 72 A0A024R1D8 A0A024R1D8 A0A024R1D8 A0A024R1D8 A0A024R1D8 A0A024R1D8 A0A024R1D8 A0A0D9RCS3 A0A0D9RCS3 A0A0D9RCS3
(62 more...)
[G-protein-coupled receptor] kinase. [EC: 2.7.11.16]
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.
  • All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate.
  • (cf. EC 2.7.11.14 and EC 2.7.11.15).
 5 E1JGX2 E1JGX2 P32865 P32865 Q09639