The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 4: IQ motif and SEC7 domain-containing protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
ARF guanyl-nucleotide exchange factor activity GO:0005086
Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
7 E1JI59 (/ISS) Q5U112 (/ISS) Q5U159 (/ISS) Q6U9V3 (/ISS) Q7KTX2 (/ISS) Q95U36 (/ISS) Q9VP80 (/ISS)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
7 E1JI59 (/IDA) Q5U112 (/IDA) Q5U159 (/IDA) Q6U9V3 (/IDA) Q7KTX2 (/IDA) Q95U36 (/IDA) Q9VP80 (/IDA)
ARF guanyl-nucleotide exchange factor activity GO:0005086
Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
3 Q5JU85 (/IMP) Q5JU85 (/IMP) Q5JU85 (/IMP)
ARF guanyl-nucleotide exchange factor activity GO:0005086
Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q5DU25 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q6DN90 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q8R0S2 (/IPI)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
7 E1JI59 (/IMP) Q5U112 (/IMP) Q5U159 (/IMP) Q6U9V3 (/IMP) Q7KTX2 (/IMP) Q95U36 (/IMP) Q9VP80 (/IMP)
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
7 E1JI59 (/IMP) Q5U112 (/IMP) Q5U159 (/IMP) Q6U9V3 (/IMP) Q7KTX2 (/IMP) Q95U36 (/IMP) Q9VP80 (/IMP)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
7 E1JI59 (/IMP) Q5U112 (/IMP) Q5U159 (/IMP) Q6U9V3 (/IMP) Q7KTX2 (/IMP) Q95U36 (/IMP) Q9VP80 (/IMP)
Positive regulation of ARF protein signal transduction GO:0032014
Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction.
7 E1JI59 (/ISS) Q5U112 (/ISS) Q5U159 (/ISS) Q6U9V3 (/ISS) Q7KTX2 (/ISS) Q95U36 (/ISS) Q9VP80 (/ISS)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
3 Q5JU85 (/IDA) Q5JU85 (/IDA) Q5JU85 (/IDA)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
3 Q5JU85 (/IMP) Q5JU85 (/IMP) Q5JU85 (/IMP)
Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696
Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane.
3 Q5JU85 (/IDA) Q5JU85 (/IDA) Q5JU85 (/IDA)
Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696
Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane.
3 Q5JU85 (/IMP) Q5JU85 (/IMP) Q5JU85 (/IMP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 E7EZE5 (/IGI) X1WBR0 (/IGI)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 E7EZE5 (/IMP) X1WBR0 (/IMP)
Vasculature development GO:0001944
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
2 E7EZE5 (/IGI) X1WBR0 (/IGI)
Lymphangiogenesis GO:0001946
Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
2 E7EZE5 (/IMP) X1WBR0 (/IMP)
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
1 Q7KTX2 (/IGI)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 Q5DU25 (/ISO)
Positive regulation of keratinocyte migration GO:0051549
Any process that activates or increases the frequency, rate or extent of keratinocyte migration.
1 Q8R0S2 (/IMP)
Positive regulation of keratinocyte migration GO:0051549
Any process that activates or increases the frequency, rate or extent of keratinocyte migration.
1 Q6DN90 (/ISS)
Positive regulation of synaptic transmission, glutamatergic GO:0051968
Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
1 A0A0G2JZX5 (/IMP)
Positive regulation of synaptic transmission, glutamatergic GO:0051968
Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
1 Q5DU25 (/ISO)
Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696
Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane.
1 Q5DU25 (/ISO)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
1 Q8R0S2 (/IDA)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
1 Q8R0S2 (/IMP)
Positive regulation of long-term synaptic depression GO:1900454
Any process that activates or increases the frequency, rate or extent of long term synaptic depression.
1 A0A0G2JZX5 (/IMP)
Positive regulation of long-term synaptic depression GO:1900454
Any process that activates or increases the frequency, rate or extent of long term synaptic depression.
1 Q5DU25 (/ISO)
Positive regulation of adherens junction organization GO:1903393
Any process that activates or increases the frequency, rate or extent of adherens junction organization.
1 Q8R0S2 (/IMP)
Positive regulation of adherens junction organization GO:1903393
Any process that activates or increases the frequency, rate or extent of adherens junction organization.
1 Q6DN90 (/ISS)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
7 E1JI59 (/ISS) Q5U112 (/ISS) Q5U159 (/ISS) Q6U9V3 (/ISS) Q7KTX2 (/ISS) Q95U36 (/ISS) Q9VP80 (/ISS)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
4 Q5JU85 (/IDA) Q5JU85 (/IDA) Q5JU85 (/IDA) Q8R0S2 (/IDA)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
4 Q5JU85 (/IMP) Q5JU85 (/IMP) Q5JU85 (/IMP) Q8R0S2 (/IMP)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 A0A087WWK8 (/IDA) Q6DN90 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 A0A087WWK8 (/IDA) Q6DN90 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 Q5DU25 (/IDA) Q8R0S2 (/IDA)
Postsynaptic density, intracellular component GO:0099092
A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
2 Q5DU25 (/IDA) Q8R0S2 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q8R0S2 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q6DN90 (/HDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q8R0S2 (/ISO)
Photoreceptor ribbon synapse GO:0098684
A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon.
1 Q5DU25 (/IDA)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
1 Q5DU25 (/ISO)
Presynaptic active zone cytoplasmic component GO:0098831
A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles.
1 Q5DU25 (/IDA)
Postsynaptic density membrane GO:0098839
The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
1 Q5DU25 (/IDA)
Postsynaptic density membrane GO:0098839
The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
1 Q5DU25 (/IMP)