CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 39: Tensin 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
10 | A0A087WQ94 (/TAS) A0A087WQM0 (/TAS) A0A087WQS0 (/TAS) A0A087WRU0 (/TAS) A0A1D5RM59 (/TAS) E9Q0S6 (/TAS) Q3U0Q9 (/TAS) Q7TPM8 (/TAS) Q7TSV1 (/TAS) Q9DBT6 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | Q63HR2 (/IPI) Q68CZ2 (/IPI) Q8IZW8 (/IPI) Q9HBL0 (/IPI) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | Q9HBL0 (/HDA) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | Q8CGB6 (/ISO) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | Q63HR2 (/IPI) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | Q8CGB6 (/ISO) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | Q8CGB6 (/ISO) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cell-substrate junction assembly GO:0007044
The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.
|
10 | A0A087WQ94 (/IMP) A0A087WQM0 (/IMP) A0A087WQS0 (/IMP) A0A087WRU0 (/IMP) A0A1D5RM59 (/IMP) E9Q0S6 (/IMP) Q3U0Q9 (/IMP) Q7TPM8 (/IMP) Q7TSV1 (/IMP) Q9DBT6 (/IMP) |
|
Fibroblast migration GO:0010761
Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.
|
10 | A0A087WQ94 (/IMP) A0A087WQM0 (/IMP) A0A087WQS0 (/IMP) A0A087WRU0 (/IMP) A0A1D5RM59 (/IMP) E9Q0S6 (/IMP) Q3U0Q9 (/IMP) Q7TPM8 (/IMP) Q7TSV1 (/IMP) Q9DBT6 (/IMP) |
|
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
|
1 | Q8CGB6 (/IMP) |
|
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q8IZW8 (/IDA) |
|
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q8BZ33 (/ISO) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q5SSZ5 (/IMP) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q63HR2 (/IMP) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q8CGB6 (/ISO) |
|
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
|
1 | Q8CGB6 (/IMP) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | Q5SSZ5 (/IMP) |
|
Cellular homeostasis GO:0019725
Any process involved in the maintenance of an internal steady state at the level of the cell.
|
1 | Q8CGB6 (/IMP) |
|
Collagen metabolic process GO:0032963
The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
1 | Q8CGB6 (/IMP) |
|
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
|
1 | Q8CGB6 (/IMP) |
|
Lung alveolus development GO:0048286
The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
|
1 | Q5SSZ5 (/IMP) |
|
Multicellular organismal homeostasis GO:0048871
Any process involved in the maintenance of an internal steady state at the level of the multicellular organism.
|
1 | Q8CGB6 (/IMP) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
18 |
A0A087WQ94 (/IDA)
A0A087WQM0 (/IDA)
A0A087WQS0 (/IDA)
A0A087WRU0 (/IDA)
A0A087WWW7 (/IDA)
A0A1D5RM59 (/IDA)
E9PF55 (/IDA)
E9PGF5 (/IDA)
E9Q0S6 (/IDA)
H0Y4U1 (/IDA)
(8 more) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
13 |
A0A087WQ94 (/ISO)
A0A087WQM0 (/ISO)
A0A087WQS0 (/ISO)
A0A087WRU0 (/ISO)
A0A1D5RM59 (/ISO)
E9Q0S6 (/ISO)
Q3U0Q9 (/ISO)
Q5SSZ5 (/ISO)
Q7TPM8 (/ISO)
Q7TSV1 (/ISO)
(3 more) |
|
Cell-substrate junction GO:0030055
A cell junction that forms a connection between a cell and the extracellular matrix.
|
10 | A0A087WQ94 (/IDA) A0A087WQM0 (/IDA) A0A087WQS0 (/IDA) A0A087WRU0 (/IDA) A0A1D5RM59 (/IDA) E9Q0S6 (/IDA) Q3U0Q9 (/IDA) Q7TPM8 (/IDA) Q7TSV1 (/IDA) Q9DBT6 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
3 | Q63HR2 (/HDA) Q68CZ2 (/HDA) Q9HBL0 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q68CZ2 (/TAS) Q8IZW8 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q68CZ2 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q5SSZ5 (/ISO) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
1 | Q8CGB6 (/ISS) |