CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 367: Neutral sphingomyelinase activation associated fac...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Death receptor binding GO:0005123
Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).
|
1 | O35242 (/TAS) |
|
Sphingomyelin phosphodiesterase activator activity GO:0016230
Increases the activity of the enzyme sphingomyelin phosphodiesterase.
|
1 | O35242 (/ISO) |
There are 4 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Leukocyte chemotaxis involved in inflammatory response GO:0002232
The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.
|
3 | A0A2R8RZN8 (/IMP) F1QZ06 (/IMP) Q567K4 (/IMP) |
|
Leukocyte chemotaxis involved in immune response GO:0002233
The movement of an immune cell in response to an external stimulus a part of an immune response.
|
3 | A0A2R8RZN8 (/IMP) F1QZ06 (/IMP) Q567K4 (/IMP) |
|
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
3 | A0A2R8RZN8 (/IMP) F1QZ06 (/IMP) Q567K4 (/IMP) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | O35242 (/ISO) |
There are 0 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.