The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 204: kinesin-like protein unc-104 isoform X6

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P23678 (/IPI)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
1 P23678 (/IDA)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 P23678 (/IDA)
ATP-dependent microtubule motor activity, plus-end-directed GO:0008574
Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP.
1 P23678 (/IDA)
GTP-dependent protein binding GO:0030742
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) when at least one of the interacting partners is in the GTP-bound state.
1 A1ZAJ2 (/IPI)
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
1 P23678 (/IPI)
Phosphatidylinositol-4-phosphate binding GO:0070273
Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
1 P23678 (/IDA)

There are 48 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Vesicle transport along microtubule GO:0047496
The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.
4 Q17BU3 (/ISS) Q28WQ1 (/ISS) Q28WQ1 (/ISS) Q7PHR1 (/ISS)
Synaptic vesicle transport GO:0048489
The directed movement of synaptic vesicles.
4 Q17BU3 (/ISS) Q28WQ1 (/ISS) Q28WQ1 (/ISS) Q7PHR1 (/ISS)
Anterograde axonal transport GO:0008089
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
2 A1ZAJ2 (/IMP) P23678 (/IMP)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
2 A1ZAJ2 (/IMP) P23678 (/IMP)
Anterograde synaptic vesicle transport GO:0048490
The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse.
2 A1ZAJ2 (/IMP) P23678 (/IMP)
Reproduction GO:0000003
The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
1 P23678 (/IMP)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 P23678 (/IMP)
Regulation of striated muscle contraction GO:0006942
Any process that modulates the frequency, rate or extent of striated muscle contraction.
1 P23678 (/IMP)
Microtubule-based movement GO:0007018
A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
1 P23678 (/IDA)
Neuron-neuron synaptic transmission GO:0007270
The process of synaptic transmission from a neuron to another neuron across a synapse.
1 P23678 (/IMP)
Synaptic transmission, cholinergic GO:0007271
The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 P23678 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 A1ZAJ2 (/IMP)
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
1 P23678 (/IGI)
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
1 P23678 (/IMP)
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
1 A1ZAJ2 (/IMP)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
1 P23678 (/IMP)
Axo-dendritic transport GO:0008088
The directed movement of organelles or molecules along microtubules in neuron projections.
1 A1ZAJ2 (/IMP)
Larval locomotory behavior GO:0008345
Locomotory behavior in a larval (immature) organism.
1 A1ZAJ2 (/IMP)
Positive regulation of necrotic cell death GO:0010940
Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.
1 P23678 (/IGI)
Synaptic vesicle maturation GO:0016188
Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle.
1 A1ZAJ2 (/IMP)
Neuron remodeling GO:0016322
The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.
1 P23678 (/IMP)
Molting cycle, collagen and cuticulin-based cuticle GO:0018996
The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans.
1 P23678 (/IMP)
Defecation GO:0030421
The expulsion of feces from the rectum.
1 P23678 (/IMP)
Regulation of axon extension GO:0030516
Any process that modulates the rate, direction or extent of axon extension.
1 P23678 (/IMP)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 A1ZAJ2 (/IMP)
Positive regulation of growth rate GO:0040010
Any process that increases the rate of growth of all or part of an organism.
1 P23678 (/IMP)
Regulation of locomotion GO:0040012
Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
1 A1ZAJ2 (/IMP)
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
1 P23678 (/IMP)
Receptor clustering GO:0043113
The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
1 P23678 (/IMP)
Regulated exocytosis GO:0045055
A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.
1 P23678 (/IMP)
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
1 A1ZAJ2 (/IMP)
Positive regulation of synaptic growth at neuromuscular junction GO:0045887
Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction.
1 P23678 (/IMP)
Filopodium assembly GO:0046847
The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
1 A1ZAJ2 (/IMP)
Vesicle transport along microtubule GO:0047496
The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.
1 A1ZAJ2 (/IMP)
Synaptic vesicle transport GO:0048489
The directed movement of synaptic vesicles.
1 A1ZAJ2 (/IMP)
Anterograde synaptic vesicle transport GO:0048490
The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse.
1 P23678 (/IDA)
Regulation of dendrite morphogenesis GO:0048814
Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
1 A1ZAJ2 (/IMP)
Regulation of synapse organization GO:0050807
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
1 P23678 (/IGI)
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 A1ZAJ2 (/IMP)
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 P23678 (/IMP)
Positive regulation of intracellular protein transport GO:0090316
Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.
1 P23678 (/IMP)
Positive regulation of anterograde dense core granule transport GO:1901953
Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport.
1 P23678 (/IMP)
Regulation of protein localization to synapse GO:1902473
Any process that modulates the frequency, rate or extent of protein localization to synapse.
1 P23678 (/IMP)
Positive regulation of pharyngeal pumping GO:1903746
Any process that activates or increases the frequency, rate or extent of pharyngeal pumping.
1 P23678 (/IMP)
Negative regulation of dense core granule transport GO:1904810
Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport.
1 P23678 (/IMP)
Positive regulation of anterior/posterior axon guidance GO:1905488
Any process that activates or increases the frequency, rate or extent of anterior/posterior axon guidance.
1 P23678 (/IGI)
Positive regulation of anterior/posterior axon guidance GO:1905488
Any process that activates or increases the frequency, rate or extent of anterior/posterior axon guidance.
1 P23678 (/IMP)
Positive regulation of presynapse assembly GO:1905608
Any process that activates or increases the frequency, rate or extent of presynapse assembly.
1 P23678 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
4 Q17BU3 (/ISS) Q28WQ1 (/ISS) Q28WQ1 (/ISS) Q7PHR1 (/ISS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 A1ZAJ2 (/IDA) P23678 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 A1ZAJ2 (/IDA) P23678 (/IDA)
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
1 A1ZAJ2 (/IMP)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P23678 (/IDA)
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
1 P23678 (/IDA)